PTGER2 (prostaglandin E receptor 2) - Rat Genome Database

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Gene: PTGER2 (prostaglandin E receptor 2) Canis lupus familiaris
Analyze
Symbol: PTGER2
Name: prostaglandin E receptor 2
RGD ID: 12343678
Description: ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; ASSOCIATED WITH aspirin-induced respiratory disease (ortholog); asthma, nasal polyps, and aspirin intolerance (ortholog); endometriosis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; prostaglandin E2 receptor EP2 subtype; prostaglandin E2 receptor subtype EP2; prostanoid EP2 receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1828,523,318 - 28,536,936 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl828,522,681 - 28,536,922 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha828,274,789 - 28,288,408 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0828,698,142 - 28,712,635 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl828,699,025 - 28,712,635 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1828,369,315 - 28,383,055 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0828,428,898 - 28,442,522 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0828,777,540 - 28,791,160 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:10410384   PMID:18280063   PMID:19005164   PMID:21716255   PMID:22301074   PMID:30032202   PMID:32385388  


Genomics

Comparative Map Data
PTGER2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1828,523,318 - 28,536,936 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl828,522,681 - 28,536,922 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha828,274,789 - 28,288,408 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0828,698,142 - 28,712,635 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl828,699,025 - 28,712,635 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1828,369,315 - 28,383,055 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0828,428,898 - 28,442,522 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0828,777,540 - 28,791,160 (+)NCBIUU_Cfam_GSD_1.0
PTGER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381452,314,312 - 52,328,598 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1452,314,305 - 52,328,598 (+)EnsemblGRCh38hg38GRCh38
GRCh371452,781,030 - 52,795,316 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361451,850,863 - 51,865,074 (+)NCBINCBI36Build 36hg18NCBI36
Build 341451,850,862 - 51,865,070NCBI
Celera1432,648,601 - 32,662,908 (+)NCBICelera
Cytogenetic Map14q22.1NCBI
HuRef1432,941,341 - 32,955,648 (+)NCBIHuRef
CHM1_11452,720,192 - 52,734,499 (+)NCBICHM1_1
T2T-CHM13v2.01446,521,407 - 46,535,692 (+)NCBIT2T-CHM13v2.0
Ptger2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391445,225,568 - 45,241,277 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1445,225,652 - 45,241,277 (+)EnsemblGRCm39 Ensembl
GRCm381444,988,111 - 45,003,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1444,988,195 - 45,003,820 (+)EnsemblGRCm38mm10GRCm38
MGSCv371445,607,786 - 45,623,495 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361443,910,468 - 43,925,027 (+)NCBIMGSCv36mm8
Celera1441,179,301 - 41,195,008 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1422.68NCBI
Ptger2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81520,694,765 - 20,708,475 (+)NCBIGRCr8
mRatBN7.21518,215,013 - 18,228,714 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1518,217,285 - 18,228,714 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1521,008,805 - 21,020,249 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01521,965,749 - 21,977,190 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01520,222,303 - 20,233,747 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01519,336,029 - 19,349,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1519,338,175 - 19,350,210 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01523,301,463 - 23,315,207 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41520,205,443 - 20,216,872 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11520,878,084 - 20,889,615 (+)NCBI
Celera1518,649,190 - 18,660,619 (+)NCBICelera
Cytogenetic Map15p14NCBI
Ptger2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540910,757,888 - 10,774,688 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540910,760,801 - 10,775,197 (-)NCBIChiLan1.0ChiLan1.0
PTGER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21553,441,812 - 53,459,334 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11452,661,559 - 52,676,942 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01432,910,755 - 32,926,138 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11451,195,381 - 51,209,686 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1451,195,381 - 51,209,686 (+)Ensemblpanpan1.1panPan2
Ptger2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864076,666,763 - 76,679,725 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366972,440,901 - 2,453,975 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366972,440,943 - 2,453,897 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1181,994,560 - 182,009,953 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11181,993,961 - 182,009,959 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21202,268,089 - 202,282,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTGER2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12429,395,799 - 29,410,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2429,396,464 - 29,409,575 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605317,664,018 - 17,678,316 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptger2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473116,726,975 - 16,741,557 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473116,729,846 - 16,741,529 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTGER2
125 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000023338   ⟹   ENSCAFP00000021671
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl828,522,681 - 28,536,922 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845006662   ⟹   ENSCAFP00845005301
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl828,699,025 - 28,712,635 (+)Ensembl
RefSeq Acc Id: NM_001003170   ⟹   NP_001003170
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1828,523,318 - 28,536,936 (+)NCBI
Dog10K_Boxer_Tasha828,274,789 - 28,288,408 (+)NCBI
ROS_Cfam_1.0828,699,030 - 28,712,635 (+)NCBI
UMICH_Zoey_3.1828,369,315 - 28,383,055 (+)NCBI
UNSW_CanFamBas_1.0828,428,898 - 28,442,522 (+)NCBI
UU_Cfam_GSD_1.0828,777,540 - 28,791,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038672842   ⟹   XP_038528770
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0828,698,142 - 28,712,087 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001003170 (Get FASTA)   NCBI Sequence Viewer  
  XP_038528770 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD43140 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000021671.5
  ENSCAFP00030006785.1
  ENSCAFP00040007709.1
  ENSCAFP00805001978
  ENSCAFP00845005301
  ENSCAFP00845005301.1
GenBank Protein Q9XT82 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001003170   ⟸   NM_001003170
- UniProtKB: Q9XT82 (UniProtKB/Swiss-Prot),   A0A8C0L3Q2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000021671   ⟸   ENSCAFT00000023338
RefSeq Acc Id: XP_038528770   ⟸   XM_038672842
- Peptide Label: isoform X1
Ensembl Acc Id: ENSCAFP00845005301   ⟸   ENSCAFT00845006662

Promoters
RGD ID:13684203
Promoter ID:EPDNEW_C2272
Type:single initiation site
Name:PTGER2_1
Description:prostaglandin E receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1828,522,969 - 28,523,029EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014701 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00030004194 UniProtKB/Swiss-Prot
  ENSCAFG00040004719 UniProtKB/Swiss-Prot
  ENSCAFG00805001406 UniProtKB/Swiss-Prot
  ENSCAFG00845003728 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000023338.5 UniProtKB/Swiss-Prot
  ENSCAFT00030007739.1 UniProtKB/Swiss-Prot
  ENSCAFT00040008881.1 UniProtKB/Swiss-Prot
  ENSCAFT00805002545 UniProtKB/Swiss-Prot
  ENSCAFT00845006662 ENTREZGENE
  ENSCAFT00845006662.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Prostanoid_rcpt UniProtKB/Swiss-Prot
  Prostglndn_EP2_rcpt UniProtKB/Swiss-Prot
KEGG Report cfa:403797 UniProtKB/Swiss-Prot
NCBI Gene PTGER2 ENTREZGENE
PANTHER PTHR11866 UniProtKB/Swiss-Prot
  PTHR11866:SF8 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  PROSTANOIDR UniProtKB/Swiss-Prot
  PRSTNOIDEP2R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A8C0L3Q2 ENTREZGENE
  PE2R2_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:45143 ENTREZGENE