MUC2 (mucin 2, oligomeric mucus/gel-forming) - Rat Genome Database

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Gene: MUC2 (mucin 2, oligomeric mucus/gel-forming) Pan paniscus
Analyze
Symbol: MUC2
Name: mucin 2, oligomeric mucus/gel-forming
RGD ID: 12007865
Description: ENCODES a protein that exhibits cupric ion binding (ortholog); cuprous ion binding (ortholog); extracellular matrix structural constituent (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to interleukin-1 (ortholog); cellular response to tumor necrosis factor (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); adenoma (ortholog); allergic conjunctivitis (ortholog); FOUND IN inner mucus layer (ortholog); mucus layer (ortholog); outer mucus layer (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mucin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,487,647 - 3,523,891 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,698,364 - 2,735,182 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0111,106,716 - 1,144,489 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,143,625 - 1,180,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,143,625 - 1,169,741 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 35 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MUC2Bonoboallergic conjunctivitis severityISOMUC2 (Homo sapiens)9068941 RGDPMID:17177679 and REF_RGD_ID:7349351
MUC2Bonoboasthma  ISOMuc2 (Mus musculus)9068941 RGDPMID:14594655 and REF_RGD_ID:7349354
MUC2Bonoboasthma  ISOMUC2 (Homo sapiens)9068941associated with hypersensitivityRGDPMID:11062147 and REF_RGD_ID:5131178
MUC2BonoboBarrett's esophagus disease_progressionISOMUC2 (Homo sapiens)9068941 RGDPMID:23011828 and REF_RGD_ID:7349348
MUC2BonoboCestode Infections  ISOMuc2 (Rattus norvegicus)9068941 RGDPMID:17187651 and REF_RGD_ID:7349350
MUC2Bonobocholangiocarcinoma  ISOMUC2 (Homo sapiens)9068941mRNA:decreased expression:bile ductRGDPMID:11680592 and REF_RGD_ID:2324948
MUC2Bonobocolitis  ISOIl10 (Mus musculus)9068941protein:decreased sulfation:descending colonRGDPMID:12395902 and REF_RGD_ID:7349356
MUC2Bonobocolitis  ISOMuc2 (Rattus norvegicus)9068941mRNA:decreased expression:colonRGDPMID:19220658 and REF_RGD_ID:2324675
MUC2Bonobocolitis treatmentISOMuc2 (Rattus norvegicus)9068941 RGDPMID:21949848 more ...
MUC2Bonobocolon cancer  ISOMuc2 (Rattus norvegicus)9068941protein:decreased expression:colonRGDPMID:17847023 and REF_RGD_ID:7349371
MUC2Bonobocolon cancer  ISOMuc2 (Rattus norvegicus)9068941mRNA:decreased expression:colonRGDPMID:20459814 and REF_RGD_ID:7349368
MUC2Bonobocystic fibrosis  ISOMUC2 (Homo sapiens)9068941mRNA:increased expression:nasal mucosa (human)RGDPMID:9155717 and REF_RGD_ID:5131426
MUC2Bonobocystitis  ISOMUC2 (Homo sapiens)9068941 RGDPMID:17659847 and REF_RGD_ID:7349345
MUC2BonoboEndotoxemia  ISOMuc2 (Rattus norvegicus)9068941 RGDPMID:19099858 and REF_RGD_ID:7349370
MUC2BonoboEscherichia Coli Infections  ISOMuc2 (Rattus norvegicus)9068941 RGDPMID:23798529 and REF_RGD_ID:7349358
MUC2BonoboFetal Growth Retardation  ISOMuc2 (Rattus norvegicus)9068941 RGDPMID:19287349 and REF_RGD_ID:7349369
MUC2BonoboGallbladder Neoplasms  ISOMUC2 (Homo sapiens)9068941protein:increased expression:gallbladderRGDPMID:15260848 and REF_RGD_ID:2324651
MUC2BonoboInflammation  ISOMuc2 (Rattus norvegicus)9068941protein:altered expression:colonRGDPMID:15980276 and REF_RGD_ID:8693640
MUC2Bonobointestinal disease treatmentISOMuc2 (Rattus norvegicus)9068941 RGDPMID:22293291 and REF_RGD_ID:7349361
MUC2Bonoboischemia  ISOMuc2 (Rattus norvegicus)9068941protein:decreased expression:jejunumRGDPMID:22768227 and REF_RGD_ID:7349363
1 to 20 of 35 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MUC2BonoboBeckwith-Wiedemann syndrome  ISOMUC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Beckwith-Wiedemann syndromeClinVarPMID:21910219 more ...
MUC2Bonobodelta beta-thalassemia  ISOMUC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Thalassemia and gamma-delta-betaClinVarPMID:2798417
MUC2Bonobodevelopmental and epileptic encephalopathy  ISOMUC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:28492532
MUC2Bonoboearly infantile epileptic encephalopathy  ISOMUC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:28492532
MUC2Bonoboimmunodeficiency 39  ISOMUC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 39ClinVarPMID:28492532
MUC2Bonoboneuronal ceroid lipofuscinosis  ISOMUC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neuronal ceroid lipofuscinosisClinVarPMID:28492532
MUC2BonoboSegawa Syndrome, Autosomal Recessive  ISOMUC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive DOPA responsive dystoniaClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MUC2Bonoboadenocarcinoma  ISOMUC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:12468628
MUC2Bonoboadenoma  ISOMUC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:12468628
MUC2BonoboIntestinal Neoplasms  ISOMUC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:12468628
MUC2Bonoborectal benign neoplasm  ISOMUC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:12468628
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MUC2Bonoboinflammatory bowel disease  ISOMuc2 (Mus musculus)9068941 MouseDO 


Biological Process
1 to 19 of 19 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MUC2Bonoboapoptotic process acts_upstream_of_or_withinISOMGI:21839239068941 PMID:11872843MGIPMID:11872843
MUC2Bonobocellular response to interleukin-1  ISOMuc2 (Chinchilla lanigera)9068941 RGDPMID:15492162 more ...
MUC2Bonobocellular response to tumor necrosis factor  ISOMuc2 (Rattus norvegicus)9068941 RGDPMID:18507686 and REF_RGD_ID:2324885
MUC2Bonobocellular response to tumor necrosis factor  ISOMuc2 (Chinchilla lanigera)9068941 RGDPMID:15492162 more ...
MUC2Bonobodetoxification of copper ion involved_inISOMUC2 (Homo sapiens)9068941 PMID:36206754UniProtPMID:36206754
MUC2Bonoboepithelial cell development acts_upstream_of_or_withinISOMGI:21839239068941 PMID:11872843MGIPMID:11872843
MUC2Bonobohost-mediated regulation of intestinal microbiota composition involved_inISOMuc2 (Mus musculus)9068941 PMID:33093110UniProtPMID:33093110
MUC2Bonobomaintenance of gastrointestinal epithelium involved_inISOMUC2 (Homo sapiens)9068941 PMID:17058067UniProtPMID:17058067
MUC2Bonobomaintenance of gastrointestinal epithelium involved_inISOMuc2 (Mus musculus)9068941 PMID:33093110 and PMID:35337837UniProtPMID:33093110 and PMID:35337837
MUC2Bonobomucus secretion involved_inISOMUC2 (Homo sapiens)9068941 PMID:17058067UniProtPMID:17058067
MUC2Bonobomucus secretion involved_inISOMuc2 (Mus musculus)9068941 PMID:35337837UniProtPMID:35337837
MUC2Bonobonegative regulation of cell migration acts_upstream_of_or_withinISOMGI:21839239068941 PMID:11872843MGIPMID:11872843
MUC2Bonobonegative regulation of cell population proliferation acts_upstream_of_or_withinISOMGI:21839239068941 PMID:11872843MGIPMID:11872843
MUC2Bonobopositive regulation of apoptotic process acts_upstream_of_or_withinISOMGI:21839239068941 PMID:11872843MGIPMID:11872843
MUC2Bonoboresponse to Gram-positive bacterium  ISOMuc2 (Rattus norvegicus)9068941Bifidobacterium bifidumRGDPMID:20501441 and REF_RGD_ID:2324672
MUC2Bonoboresponse to hormone  ISOMuc2 (Rattus norvegicus)9068941 RGDPMID:17495032 and REF_RGD_ID:2303604
MUC2Bonoboresponse to lipopolysaccharide  ISOMuc2 (Rattus norvegicus)9068941 RGDPMID:17417665 and REF_RGD_ID:2324678
MUC2Bonoboresponse to transforming growth factor beta  ISOMuc2 (Rattus norvegicus)9068941 RGDPMID:15980276 and REF_RGD_ID:8693640
MUC2Bonoboresponse to vitamin A  ISOMuc2 (Rattus norvegicus)9068941 RGDPMID:18495461 and REF_RGD_ID:2324677
1 to 19 of 19 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MUC2Bonoboextracellular matrix located_inIEAPANTHER:PTN002602352150520179 TreeGrafterGO_REF:0000118
MUC2Bonoboextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
MUC2Bonoboextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
MUC2Bonoboextracellular space located_inIEAPANTHER:PTN002602352150520179 TreeGrafterGO_REF:0000118
MUC2Bonoboinner mucus layer located_inISOMuc2 (Mus musculus)9068941 PMID:18806221 and PMID:19432394UniProtPMID:18806221 and PMID:19432394
MUC2Bonobomucus layer  ISOMuc2 (Rattus norvegicus)9068941 RGDPMID:21629776 and REF_RGD_ID:7349366
MUC2Bonobomucus layer is_active_inISOMuc2 (Mus musculus)9068941 PMID:35337837UniProtPMID:35337837
MUC2Bonoboouter mucus layer located_inISOMuc2 (Mus musculus)9068941 PMID:18806221 more ...UniProtPMID:18806221 more ...

PMID:22301074   PMID:30032202  



MUC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,487,647 - 3,523,891 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,698,364 - 2,735,182 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0111,106,716 - 1,144,489 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,143,625 - 1,180,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,143,625 - 1,169,741 (+)Ensemblpanpan1.1panPan2
MUC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,074,874 - 1,110,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,074,875 - 1,110,511 (+)EnsemblGRCh38hg38GRCh38
GRCh37111,074,874 - 1,104,416 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,064,902 - 1,094,419 (+)NCBINCBI36Build 36hg18NCBI36
Build 34111,064,874 - 1,094,416NCBI
Cytogenetic Map11p15.5NCBI
HuRef11897,783 - 932,205 (+)NCBIHuRef
CHM1_1111,073,796 - 1,103,733 (+)NCBICHM1_1
T2T-CHM13v2.0111,144,674 - 1,182,053 (+)NCBIT2T-CHM13v2.0
Muc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,276,583 - 141,308,428 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,276,583 - 141,308,430 (+)EnsemblGRCm39 Ensembl
GRCm387141,690,340 - 141,754,691 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,690,340 - 141,754,693 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,930,517 - 148,940,598 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv377148,876,261 - 148,890,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,553,920 - 141,565,981 (+)NCBIMGSCv36mm8
Celera7141,484,086 - 141,510,531 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.1NCBI
Muc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,225,775 - 206,261,280 (+)NCBIGRCr8
mRatBN7.21196,799,494 - 196,831,740 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,799,517 - 196,831,756 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01214,663,929 - 214,693,197 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,664,537 - 214,693,043 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01221,581,822 - 221,611,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1194,430,946 - 194,458,668 (+)NCBICelera
Celera1194,458,772 - 194,461,359 (+)NCBICelera
Cytogenetic Map1q41NCBI
Muc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,108,826 - 11,135,697 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,108,826 - 11,135,697 (-)NCBIChiLan1.0ChiLan1.0
MUC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,416,347 - 45,438,226 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01846,091,348 - 46,116,933 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11845,539,151 - 45,565,262 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01845,119,185 - 45,145,631 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,857,452 - 45,883,423 (+)NCBIUU_Cfam_GSD_1.0
Muc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947806,466 - 835,556 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493681660,499 - 91,628 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493681660,499 - 91,628 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2689,364 - 710,330 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12689,363 - 719,542 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140 - 7,521 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MUC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11893,554 - 926,854 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603898,020,755 - 98,058,827 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Muc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,493,125 - 21,522,535 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_034934139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063607947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000011457   ⟹   ENSPPAP00000002359
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,143,625 - 1,169,741 (+)Ensembl
RefSeq Acc Id: XM_063607947   ⟹   XP_063464017
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v293,487,647 - 3,523,891 (+)NCBI
Protein RefSeqs XP_063464017 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000002359.1
Ensembl Acc Id: ENSPPAP00000002359   ⟸   ENSPPAT00000011457
RefSeq Acc Id: XP_063464017   ⟸   XM_063607947
VWFD



1 to 23 of 23 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000010427 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000011457.1 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
InterPro Mucin_vWF_Thrombospondin_sf UniProtKB/TrEMBL
  Ser_inhib-like_sf UniProtKB/TrEMBL
  TIL_dom UniProtKB/TrEMBL
  Unchr_dom_Cys-rich UniProtKB/TrEMBL
  VWF_dom UniProtKB/TrEMBL
  VWF_type-D UniProtKB/TrEMBL
  WxxW_domain UniProtKB/TrEMBL
NCBI Gene MUC2 ENTREZGENE
PANTHER EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED UniProtKB/TrEMBL
  MUCIN-2 UniProtKB/TrEMBL
Pfam Mucin2_WxxW UniProtKB/TrEMBL
  PF08742 UniProtKB/TrEMBL
  TIL UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
PROSITE VWFD UniProtKB/TrEMBL
SMART SM00832 UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
Superfamily-SCOP SSF57567 UniProtKB/TrEMBL
UniProt A0A2R8ZI36_PANPA UniProtKB/TrEMBL
1 to 23 of 23 rows