RGD Reference Report - Mucin production and composition is altered in dextran sulfate sodium-induced colitis in rats. - Rat Genome Database

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Mucin production and composition is altered in dextran sulfate sodium-induced colitis in rats.

Authors: Faure, M  Moennoz, D  Montigon, F  Mettraux, C  Mercier, S  Schiffrin, EJ  Obled, C  Breuille, D  Boza, J 
Citation: Faure M, etal., Dig Dis Sci. 2003 Jul;48(7):1366-73.
RGD ID: 2324685
Pubmed: PMID:12870797   (View Abstract at PubMed)

We evaluated the small and large intestinal mucin production in a rat model of human ulcerative colitis by measuring the in vivo fractional synthesis rate (FSR) and the expression of mucins. A chronic colitis was induced by oral administration of 5% dextran sulfate sodium (DSS) for 9 days followed by 2% DSS for 18 days. DSS-treated rats showed increased colonic MUC2,3 mRNA levels compared pair-fed controls. The mucin FSR was unaffected while mucin-containing goblet cells were depleted in the vicinity of lesions. In the small intestine, no inflammatory lesions were observed but ileal MUC2 mRNA levels and mucin FSR were decreased by 46% and 21%, respectively. Finally, DSS-treated rats showed a marked decrease in mucin's threonine + serine content all along the gut, which may lead to a reduction of potential O-glycosylation sites. Our data indicate that the chronic colitis may impair the mucus layer protective function all along the gut.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MUC2Humanulcerative colitis  ISOMuc2 (Rattus norvegicus)mRNA:altered expression: :RGD 
Muc2Ratulcerative colitis  IEP mRNA:altered expression: :RGD 
Muc2Mouseulcerative colitis  ISOMuc2 (Rattus norvegicus)mRNA:altered expression: :RGD 

Objects Annotated

Genes (Rattus norvegicus)
Muc2  (mucin 2, oligomeric mucus/gel-forming)

Genes (Mus musculus)
Muc2  (mucin 2)

Genes (Homo sapiens)
MUC2  (mucin 2, oligomeric mucus/gel-forming)


Additional Information