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REFERENCE - CHEMICAL INTERACTIONS REPORT

RGD ID: 28912746
Species: All species
RGD Object: Reference
Acc ID: CHEBI:4814
Term: eprosartan
Definition: A member of the class of imidazoles and thiophenes that is an angiotensin II receptor antagonist used for the treatment of high blood pressure.
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1decreases expression EXP 28912746RGDeprosartan decreases expression of collagen I-a1 mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
Col3a1decreases expression EXP 28912746RGDeprosartan decreases expression of collagen III mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
Fn1decreases expression EXP 28912746RGDeprosartan decreases expression of fibronectin mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
Serpine1decreases expression EXP 28912746RGDeprosartan decreases expression of plasminogen activator inhibitor -1 mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
Tgfb1decreases expression EXP 28912746RGDeprosartan decreases expression of TGFbeta mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
FN1decreases expression ISOFn1 (Rattus norvegicus)28912746RGDeprosartan decreases expression of fibronectin mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
Fn1decreases expression ISOFn1 (Rattus norvegicus)28912746RGDeprosartan decreases expression of fibronectin mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
SERPINE1decreases expression ISOSerpine1 (Rattus norvegicus)28912746RGDeprosartan decreases expression of plasminogen activator inhibitor -1 mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
Serpine1decreases expression ISOSerpine1 (Rattus norvegicus)28912746RGDeprosartan decreases expression of plasminogen activator inhibitor -1 mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
COL1A1decreases expression ISOCol1a1 (Rattus norvegicus)28912746RGDeprosartan decreases expression of collagen I-a1 mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
Col1a1decreases expression ISOCol1a1 (Rattus norvegicus)28912746RGDeprosartan decreases expression of collagen I-a1 mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
TGFB1decreases expression ISOTgfb1 (Rattus norvegicus)28912746RGDeprosartan decreases expression of TGFbeta mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
Tgfb1decreases expression ISOTgfb1 (Rattus norvegicus)28912746RGDeprosartan decreases expression of TGFbeta mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
COL3A1decreases expression ISOCol3a1 (Rattus norvegicus)28912746RGDeprosartan decreases expression of collagen III mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
Col3a1decreases expression ISOCol3a1 (Rattus norvegicus)28912746RGDeprosartan decreases expression of collagen III mRNA in high fat high sodium fed SHRSP/A3N rat kidney 
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