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GENE - TERM ANNOTATION REPORT

RGD ID: 12718861
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: DOID:6000
Term: congestive heart failure
Definition: A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Heart_disease "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1 ISOEdn1 (Rattus norvegicus)9068941RGDmRNA,protein:increased expression:heart:PMID:10199843 REF_RGD_ID:7244167
Edn1severityISOEDN1 (Homo sapiens)9068941RGDprotein:increased secretion:plasma (human)PMID:8149524 REF_RGD_ID:4144845
Edn1treatmentISOEDN1 (Homo sapiens)9068941RGD PMID:10973842 REF_RGD_ID:8661798
Edn1 ISOEDN1 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:11136700 PMID:11707688 PMID:16360360 PMID:16762801 PMID:7967349 PMID:7969316 PMID:9861300
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