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GENE - TERM ANNOTATION REPORT

RGD ID: 12718861
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: DOID:10763
Term: hypertension
Definition: An artery disease characterized by chronic elevated blood pressure in the arteries. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Hypertension "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/24352797 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1 ISOEdn1 (Rattus norvegicus)9068941RGDprotein:increased secretion:plasma (rat)PMID:20733093 REF_RGD_ID:4144829
Edn1 ISOEDN1 (Homo sapiens)9068941RGDassociated with Diabetic Nephropathies;protein:increased secretion:plasmaPMID:18496905 REF_RGD_ID:2313283
Edn1 ISOEDN1 (Homo sapiens)9068941RGDDNA:polymorphism:exon:p.K198N (human)PMID:17444275 REF_RGD_ID:1625065
Edn1 ISOEDN1 (Homo sapiens)9068941RGDhuman gene in a rat modelPMID:11078355 REF_RGD_ID:8661804
Edn1 ISOEDN1 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:10474778 PMID:10669576 PMID:11847185 PMID:12149661 PMID:12425201 PMID:12600921 PMID:15188945 PMID:15302986 PMID:15314687 PMID:15834289 PMID:17130675 PMID:7721406 PMID:8152482 PMID:8440307
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