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GENE - TERM ANNOTATION REPORT

RGD ID: 12486175
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Bdnf
Name: brain derived neurotrophic factor
Acc ID: DOID:10652
Term: Alzheimer's disease
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Alzheimer%27s_disease "DO" "DO", http://www.merriam-webster.com/medical/alzheimer%27s%20disease "DO" "DO", http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnf ISOBdnf (Rattus norvegicus)9068941RGD PMID:20646587 REF_RGD_ID:4891131
Bdnf ISOBDNF (Homo sapiens)9068941RGDDNA:polymorphisms, haplotypes: :196G>A (p.V66M), 270C>T, 11757G>C (human)PMID:23215636 REF_RGD_ID:10059345
Bdnf ISOBDNF (Homo sapiens)9068941RGDprotein:decreased expression:parietal cortexPMID:12654514 REF_RGD_ID:10058980
Bdnfno_associationISOBDNF (Homo sapiens)9068941RGDDNA:polymorphism: :p.V66M (human)PMID:16627933 REF_RGD_ID:10059343
Bdnfno_associationISOBDNF (Homo sapiens)9068941RGDDNA:polymorphisms: :196G>A (p.V66M), 270C>T (human)PMID:16565926 REF_RGD_ID:10059346
BdnfonsetISOBDNF (Homo sapiens)9068941RGDDNA:SNP:CDS:rs1048218 (human)PMID:18780967 REF_RGD_ID:5508228
BdnftreatmentISOBdnf (Mus musculus)9068941RGD PMID:30776009 REF_RGD_ID:405850256
BdnftreatmentISOBdnf (Rattus norvegicus)9068941RGD PMID:24877042 PMID:33352241 REF_RGD_ID:10059402 REF_RGD_ID:597015751
Bdnf ISOBDNF (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:17344400
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