RGD Reference Report - The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease. - Rat Genome Database

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The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease.

Authors: Chuu, JY  Taylor, JL  Tinklenberg, J  Noda, A  Yesavage, J  Murphy GM, JR 
Citation: Chuu JY, etal., J Alzheimers Dis. 2006 Mar;9(1):43-9.
RGD ID: 10059343
Pubmed: PMID:16627933   (View Abstract at PubMed)

It is largely unknown why some patients with Alzheimer's disease (AD) decline cognitively more rapidly than others. Genetic differences among patients could influence rate of decline. Brain-derived neurotrophic factor (BDNF) is a neurotrophin important in the survival neurons and in memory function. BDNF levels are reduced in the brain in AD. The Val66Met polymorphism in the BDNF gene modifies neuronal BDNF secretion, and affects hippocampal function and memory performance. We tested the hypothesis that the BDNF Val66Met polymorphism influences rate of cognitive decline in AD. In a sample of 149 AD patients followed for an average of 3.9 years, we found no effect of BDNF Val66Met genotype on rate of change in the Mini Mental State Examination. Results were similar when we excluded patients taking an acetylcholinesterase inhibitor, those placed in a nursing home during the study, or those with a neuropathological diagnosis that included AD plus an entity other than AD. We also found no evidence that the effects of the BDNF Val66Met genotype depend on APOE genotype, which itself had no effect on rate of cognitive change. These findings suggest that the functional BDNF Val66Met variant is not a major determinant of rate of cognitive decline in AD.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
BDNFHumanAlzheimer's disease no_associationIAGP DNA:polymorphism: :p.V66M (human)RGD 
BdnfRatAlzheimer's disease no_associationISOBDNF (Homo sapiens)DNA:polymorphism: :p.V66M (human)RGD 
BdnfMouseAlzheimer's disease no_associationISOBDNF (Homo sapiens)DNA:polymorphism: :p.V66M (human)RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
BDNFHumanMental deterioration no_associationIAGP DNA:polymorphism: :p.V66MRGD 

Genes (Rattus norvegicus)
Bdnf  (brain-derived neurotrophic factor)

Genes (Mus musculus)
Bdnf  (brain derived neurotrophic factor)

Genes (Homo sapiens)
BDNF  (brain derived neurotrophic factor)