Phenominer Database Results (883 results)

 
 
How to display a graph
Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
Crl:CD(SD) partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 5 105.33 mmHg 2.71 6.05 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15561 381
Crl:CD(SD) body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 6 37.63 degrees C 0.17 0.42 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15572 381
Crl:CD(SD) absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 0.01 null 0.0 0.01 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15603 381
Crl:CD(SD) partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 5 26.0 mmHg 1.25 2.79 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15626 381
Crl:CD(SD) plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 5 0.33 mg/dl 0.02 0.04 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51897 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 21.65 mmHg 1.26 2.52 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51910 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -36.87 beats/min 22.47 59.45 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51990 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 0.91 mmHg 2.27 4.55 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50818 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 10.83 beats/min 10.18 20.36 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50822 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 5.25 beats/min 13.2 26.41 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50820 481
Crl:CD(SD) heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 394.6 beats/min 13.13 26.26 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50861 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 16.23 mmHg 3.7 7.41 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50859 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 11.78 mmHg 2.52 5.04 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50857 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 -54.89 beats/min 10.39 23.23 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51034 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 18.95 beats/min 7.34 17.98 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51260 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 5 0.36 beats/min 7.52 16.81 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51262 481
Crl:CD(SD) heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 393.45 beats/min 27.31 61.07 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51616 481
Crl:CD(SD) urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 10.47 mEq/d 1.07 3.21 flame atomic emission spectrometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51641 481
Crl:CD(SD) urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87.0 days-120.0 days 9 1.03 mg/d 0.29 0.87 automated urine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51671 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 4.73 beats/min 17.72 35.45 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51675 481
Crl:CD(SD) mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 123.14 mmHg 6.55 14.64 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50349 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 12.31 mmHg 3.92 7.83 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50385 481
Crl:CD(SD) body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 13 37.15 degrees C 0.15 0.53 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14175 381
Crl:CD(SD) partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 111.47 mmHg 1.48 3.91 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14296 381
Crl:CD(SD) absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 13 -0.48 degrees C 0.17 0.61 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13867 381
Crl:CD(SD) blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14047 381
Crl:CD(SD) partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 105.92 mmHg 2.37 7.1 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14079 381
Crl:CD(SD) absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 9.3 mmHg 3.57 8.75 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20105 381
Crl:CD(SD) mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 109.3 mmHg 3.13 8.28 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20134 381
Crl:CD(SD) partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 5 27.95 mmHg 1.61 3.6 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19685 381
Crl:CD(SD) minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 102.4 ml/min 6.05 21.82 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17581 381
Crl:CD(SD) minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 80.47 ml/min 6.29 20.85 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17583 381
Crl:CD(SD) body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 13 37.63 degrees C 0.23 0.85 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17782 381
Crl:CD(SD) heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 323.57 beats/min 6.64 18.79 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18081 381
Crl:CD(SD) heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 394.41 beats/min 15.1 42.71 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18387 381
Crl:CD(SD) heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 8 428.96 beats/min 14.47 40.93 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18389 381
Crl:CD(SD) mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 118.32 mmHg 6.53 18.47 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18767 381
Crl:CD(SD) minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 51.81 ml/min 4.42 15.93 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18964 381
Crl:CD(SD) serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 9 5.88 g/dl 0.12 0.35 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36263 401
Crl:CD(SD) mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 9 59.49 fl 0.37 1.1 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36289 401
Crl:CD(SD) serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 9 156.56 mg/dl 11.25 33.74 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36323 401
Crl:CD(SD) mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 19.47 pg 0.18 0.55 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36358 401
Crl:CD(SD) serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 9 15.89 mg/dl 0.84 2.52 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37284 401
Crl:CD(SD) serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 9 18.11 mg/dl 0.82 2.47 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37286 401
Crl:CD(SD) tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.55 ml 0.02 0.09 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18520 381
Crl:CD(SD) red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 9 8.31 x 10E6 cells/ul 0.15 0.46 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36572 401
Crl:CD(SD) respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 142.79 breaths/min 8.96 29.71 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18210 381
Crl:CD(SD) heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 10 9.36 % 4.43 14.02 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49030 461
Crl:CD(SD) heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 10 6.65 % 3.61 11.4 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49032 461
Crl:CD(SD) percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 131.59 % 25.95 82.05 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49262 461
Crl:CD(SD) left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 95.76 mmHg 10.85 32.56 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49276 461
Crl:CD(SD) heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 49.4 mmHg 4.69 14.84 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49589 461
Crl:CD(SD) left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 148.93 mmHg 4.34 13.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49804 461
Crl:CD(SD) left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 136.65 mmHg 5.53 17.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49802 461
Crl:CD(SD) absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 -0.63 degrees C 0.2 0.65 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19158 381
Crl:CD(SD) serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 9 0.21 mg/dl 0.01 0.03 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42179 401
Crl:CD(SD) serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 9 4.99 mmol/l 0.14 0.41 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39094 401
Crl:CD(SD) serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 9 2.1 g/dl 0.09 0.27 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39214 401
Crl:CD(SD) serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 9 19.44 mg/dl 0.9 2.7 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39515 401
Crl:CD(SD) plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 9 0.28 mg/dl 0.03 0.08 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39553 401
Crl:CD(SD) mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 9 32.72 g/dl 0.07 0.2 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42731 401
Crl:CD(SD) total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 9 5.48 x 1000 cells/ul 0.68 2.05 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42857 401
Crl:CD(SD) serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 9 23.11 mmol/l 0.63 1.9 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43072 401
Crl:CD(SD) blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 9 0.37 x 1000 cells/ul 0.06 0.19 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43080 401
Crl:CD(SD) blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 9 0.27 x 1000 cells/ul 0.07 0.2 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43082 401
Crl:CD(SD) percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 137.41 % 8.77 29.09 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54519 381
Crl:CD(SD) percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 106.31 % 3.84 12.75 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53606 381
Crl:CD(SD) plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 9 0.32 mg/dl 0.02 0.07 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40801 401
Crl:CD(SD) serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 9 0.22 mg/dl 0.02 0.07 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37545 401
Crl:CD(SD) serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 9 101.89 mmol/l 0.63 1.9 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41109 401
Crl:CD(SD) serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 9 76.78 mg/dl 3.27 9.8 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37907 401
Crl:CD(SD) serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 9 9.61 mg/dl 0.09 0.28 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37930 401
Crl:CD(SD) blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 9 4.56 x 1000 cells/ul 0.61 1.82 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37940 401
Crl:CD(SD) red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 9 8.86 x 10E6 cells/ul 0.08 0.24 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38151 401
Crl:CD(SD) serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 9 56.56 U/l 4.16 12.47 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38617 401
Crl:CD(SD) heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 245.03 beats/min 30.09 95.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46503 461
Crl:CD(SD) concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 0.02 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57427 522
Crl:CD(SD) acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 69.8 % 9.65 30.53 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55386 522
Crl:CD(SD) body weight control condition (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 10 337.9 g 5.2 16.5 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57703 526
Crl:CD(SD) dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 7 2.85 mg/kg 0.98 2.6 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57765 526
Crl:CD(SD) body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 15 388.3 g 9.2 35.5 whole body digital scale Moms and pups used in studies were fed Dyets 16789 381
Crl:CD(SD) concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 1.7 E-7mole 0.37 1.06 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55980 522
Crl:CD(SD) heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 10 0.23 null 0.01 0.04 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58444 526
Crl:CD(SD) body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 10 414.8 g 13.8 43.5 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56070 522
Crl:CD(SD) body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 10 264.9 g 7.0 22.2 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56072 522
Crl:CD(SD) lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 10 0.82 g/kg 0.04 0.11 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58826 526
Crl:CD(SD) lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 10 0.94 g/kg 0.04 0.12 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58828 526
Crl:CD(SD) logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 -8.3 null 0.05 0.16 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55113 522
Crl:CD(SD) hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 9 45.39 % 1.01 3.02 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59854 526
Crl:CD(SD) methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 5.48 ml/min/kg 0.35 0.99 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59862 526
Crl:CD(SD) heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 10 0.37 null 0.03 0.11 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59970 526
Crl:CD(SD) logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 -7.73 null 0.1 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56736 522
Crl:CD(SD) acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 39.72 % 4.95 21.0 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56749 522
Crl:CD(SD) concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 0.03 10E-7mol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56766 522
Crl:CD(SD) FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 25.22 ml/min/kg 2.27 5.99 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60130 526
Crl:CD(SD) sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 19 99.63 % 0.28 1.21 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57120 522
Crl:CD(SD) left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 59.39 mmHg 4.85 14.54 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45935 461
Crl:CD(SD) left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 108.65 mmHg 6.86 18.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46043 461
Crl:CD(SD) percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 81.28 % 4.11 10.87 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46164 461
Crl:CD(SD) percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 87.4 % 9.53 25.22 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46166 461
Crl:CD(SD) time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 870.38 s 51.09 161.57 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48122 461
Crl:CD(SD) heart wet weight control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 0.83 g 0.06 0.18 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48145 461
Crl:CD(SD) heart wet weight control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 1.19 g 0.08 0.25 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48143 461
Crl:CD(SD) left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 123.91 mmHg 6.22 16.46 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45016 461
Crl:CD(SD) heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 50.3 mmHg 3.23 10.21 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47381 461
Crl:CD(SD) left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 51.37 mmHg 5.7 17.1 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47393 461
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 133.0 days 19 35.9 U/l 0.87 3.8 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85436 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 133.0 days 19 32.4 U/l 0.99 4.3 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85437 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 168.0 days 19 14.3 U/l 0.8 3.5 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85456 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 105.0 days 19 14.7 U/l 0.64 2.8 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85448 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (300 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105.0 days 8 24.5 g/d 0.57 1.6 unspecified method 0.0 85465 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147.0 days 19 19.4 g/d 0.87 3.8 unspecified method 0.0 85297 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105.0 days 19 5.36 g/d/100g 0.15 0.65 unspecified method 0.0 85303 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126.0 days 19 4.62 g/d/100g 0.13 0.56 unspecified method 0.0 85305 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 78.0 days 19 0.69 mg/dl 0.15 0.64 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85341 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 78.0 days 19 21.1 mg/dl 1.08 4.7 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85356 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 70.0 days 19 14.7 mg/dl 1.1 4.8 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85355 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 147.0 days 19 17.0 mg/dl 1.24 5.4 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85366 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 147.0 days 19 19.4 mg/dl 0.78 3.4 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85367 1604
Crl:CD(SD) urine creatine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 106.0 days 19 1.71 umol/d 0.09 0.39 liquid chromatography-mass spectrometry 0.0 85381 1604
Crl:CD(SD) urine creatinine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 169.0 days 19 12.28 mg/d 0.58 2.51 liquid chromatography-mass spectrometry 0.0 85393 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 105.0 days 19 34.9 U/l 1.1 4.8 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85432 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 119.0 days 19 37.8 U/l 0.87 3.8 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85434 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 78.0 days 19 17.9 U/l 1.61 7.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85445 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 91.0 days 19 15.5 U/l 0.62 2.7 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85447 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (300 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84.0 days 8 24.1 g/d 0.53 1.5 unspecified method 0.0 85459 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105.0 days 8 5.09 g/d/100g 0.24 0.67 unspecified method 0.0 on days 32-35 85498 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (300 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126.0 days 8 4.7 g/d/100g 0.06 0.17 unspecified method 0.0 on days 53-56 85501 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (300 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168.0 days 8 4.05 g/d/100g 0.08 0.24 unspecified method 0.0 on days 95-98 85513 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 1 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 71.0 days 8 287.0 g 6.72 19.0 body weighing method 0.0 85522 1604
Crl:CD(SD) liver wet weight standard diet then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver mass male 170.0 days 8 20.1 g 0.47 1.33 unspecified method 0.0 liver weight not available 85555 1604
Crl:CD(SD) plasma acetaminophen level standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170.0 days 8 0.6 ug/ml 0.21 0.6 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 19 hr after dosing 85584 1604
Crl:CD(SD) plasma acetaminophen level area under curve standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170.0 days 8 373.9 (ug/ml) x h 38.93 110.1 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 4-19 hr dosing 4-19 hr dosing 85588 1604
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 78.0 days 19 0.41 mg/dl 0.03 0.11 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85340 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 168.0 days 19 128.0 mg/dl 1.84 8.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85337 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 168.0 days 19 15.1 mg/dl 0.46 2.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85368 1604
Crl:CD(SD) food intake rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105.0 days 19 24.5 g/d 0.37 1.6 unspecified method 0.0 85291 1604
Crl:CD(SD) food intake rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126.0 days 19 24.8 g/d 0.53 2.3 unspecified method 0.0 85294 1604
Crl:CD(SD) body weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 84.0 days 19 419.0 g 8.72 38.0 body weighing method 0.0 85312 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 78.0 days 19 126.0 mg/dl 2.06 9.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85325 1604
Crl:CD(SD) plasma creatinine level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 70.0 days 19 0.38 mg/dl 0.0 0.02 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85371 1604
Crl:CD(SD) urine creatine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 134.0 days 19 2.0 umol/d 0.13 0.57 liquid chromatography-mass spectrometry 0.0 85383 1604
Crl:CD(SD) urine taurine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 106.0 days 19 142.0 umol/d 12.64 55.1 liquid chromatography-mass spectrometry 0.0 85397 1604
Crl:CD(SD) urine creatinine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 70.0 days 19 9.72 mg/d 0.23 1.0 liquid chromatography-mass spectrometry 0.0 85386 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 133.0 days 19 17.0 U/l 0.71 3.1 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85452 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (500 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168.0 days 8 4.24 g/d/100g 0.06 0.18 unspecified method 0.0 on days 95-98 85514 1604
Crl:CD(SD) liver oxidized glutathione level to liver weight ratio standard diet then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170.0 days 8 0.19 umol/g 0.01 0.03 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 enzyme recycling method reduced liver glutathione level to liver weight ratio 85574 1604
Crl:CD(SD) plasma acetaminophen level standard diet then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170.0 days 8 88.0 ug/ml 3.89 11.0 high-performance liquid chromatography 0.0 acetaminophen dosing 240 min 4 hr after dosing 85578 1604
Crl:CD(SD) plasma acetaminophen level standard diet then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170.0 days 8 0.3 ug/ml 0.18 0.5 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 19 hr after dosing 85582 1604
Crl:CD(SD) plasma acetaminophen level standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170.0 days 8 64.3 ug/ml 9.72 27.5 high-performance liquid chromatography 0.0 acetaminophen dosing 240 min 4 hr after dosing 85581 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 70.0 days 19 35.3 U/l 1.03 4.5 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85427 1604
Crl:CD(SD) liver oxidized glutathione level to liver weight ratio standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170.0 days 8 0.14 umol/g 0.0 0.01 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 enzyme recycling method 85577 1604
Crl:CD(SD) plasma acetaminophen level area under curve standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170.0 days 8 500.6 (ug/ml) x h 64.42 182.2 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 4-19 hr dosing 4-19 hr dosing 85589 1604
Crl:CD(SD) plasma high density lipoprotein cholesterol level control condition (for 140 days) Wang HY, et al., Biol Open. 2016 Jul 15;5(7):979-86. doi: 10.1242/bio.019802. blood HDL cholesterol amount not specified 140.0 days 5 29.92 mg/dl 2.59 5.78 plasma high-density lipoprotein-cholesterol measurement test 0.0 105043 3009
Crl:CD(SD) plasma AMG-8718 maximum concentration AMG-8718 (100 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 21500.0 ng/ml 1784.38 3990.0 liquid chromatography-mass spectrometry 0.0 max conc 105423 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (600 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 124.0 um 4.2 9.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105481 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 128.1 um 3.49 7.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105492 3016
Crl:CD(SD) full retina thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 137.0 days-144.0 days 5 207.4 um 18.87 42.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105459 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (100 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 138.9 um 3.49 7.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105476 3016
Crl:CD(SD) plasma AMG-8718 level area under curve (AUC) AMG-8718 (600 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 549000.0 ng/ml/h 59479.41 133000.0 liquid chromatography-mass spectrometry 0.0 samples at 0.5, 1.5, 5, 10, 24 hours auc 105427 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 48.9 um 3.13 7.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105445 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 10.7 null 0.4 0.9 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105463 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 126.0 um 4.02 9.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105486 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 128.2 um 3.8 8.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105499 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 123.8 um 4.83 10.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105502 3016
Crl:CD(SD) plasma AMG-8718 maximum concentration AMG-8718 (100 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 81.0 days-88.0 days 5 22500.0 ng/ml 1533.94 3430.0 liquid chromatography-mass spectrometry 0.0 max conc 105429 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (600 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 59.0 days-66.0 days 5 38.6 um 1.07 2.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105437 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 11.7 null 0.31 0.7 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105452 3016
Crl:CD(SD) full retina thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 137.0 days-144.0 days 5 167.0 um 6.98 15.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105461 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (100 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 125.4 um 3.53 7.9 optical coherence tomography 0.0 optical coherence tomography inner retinal layer 105472 3016
Crl:CD(SD) serum creatinine level control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. blood creatinine amount male 112.0 days 5 0.43 mg/dl 0.03 0.07 serum creatinine analysis 0.0 100766 2521
Crl:CD(SD) minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 34.72 ml/min 2.61 8.64 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15492 381
Crl:CD(SD) absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 14.24 mmHg 2.44 6.45 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15513 381
Crl:CD(SD) tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.44 ml 0.03 0.1 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15528 381
Crl:CD(SD) partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 97.24 mmHg 2.1 5.57 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15563 381
Crl:CD(SD) heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 502.33 beats/min 11.19 27.42 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15784 381
Crl:CD(SD) percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 %change=VE during7-9 min hypercapnia/control during standard conditions 236.99 % 15.67 51.99 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15212 381
Crl:CD(SD) heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 404.0 beats/min 22.43 59.35 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50855 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -27.15 beats/min 19.46 38.92 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50952 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 13.43 mmHg 1.98 5.23 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50998 481
Crl:CD(SD) percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 152.22 % 8.04 26.68 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54169 381
Crl:CD(SD) mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 103.26 mmHg 5.16 10.33 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51392 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 -16.97 beats/min 11.37 25.42 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51529 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 4.01 mmHg 4.78 9.57 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50383 481
Crl:CD(SD) plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 2 5.07 ng/ml/h 0.24 0.33 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50415 481
Crl:CD(SD) mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 128.25 mmHg 4.46 12.62 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13453 381
Crl:CD(SD) partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 5 113.41 mmHg 3.97 8.88 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14294 381
Crl:CD(SD) absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 -3.94 mmHg 0.62 1.65 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17200 381
Crl:CD(SD) percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 %change=VE during7-9 min hypoxia/control during standard conditions 139.28 % 7.59 25.17 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17337 381
Crl:CD(SD) mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 7 119.4 mmHg 7.03 18.6 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13878 381
Crl:CD(SD) absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 83.32 beats/min 9.37 22.94 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14112 381
Crl:CD(SD) absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 -6.91 mmHg 1.15 3.05 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20984 381
Crl:CD(SD) body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 37.38 degrees C 0.15 0.49 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19994 381
Crl:CD(SD) minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 42.26 ml/min 3.37 12.14 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17904 381
Crl:CD(SD) blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 5 7.49 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18092 381
Crl:CD(SD) mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 116.18 mmHg 4.97 12.18 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18776 381
Crl:CD(SD) blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.49 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 18989 381
Crl:CD(SD) blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 9 0.58 x 1000 cells/ul 0.1 0.29 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36301 401
Crl:CD(SD) hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 9 56.52 % 0.73 2.19 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36346 401
Crl:CD(SD) serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 9 73.22 mg/dl 3.53 10.6 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36464 401
Crl:CD(SD) serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 9 8.96 mg/dl 0.21 0.64 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36717 401
Crl:CD(SD) percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 %change=VE during 2-3 min hypoxia/control during standard conditions 132.62 % 6.27 22.61 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19302 381
Crl:CD(SD) heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 5.04 g/kg 0.13 0.4 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49145 461
Crl:CD(SD) left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 91.21 mmHg 7.78 24.59 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49274 461
Crl:CD(SD) time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 971.74 s 41.6 131.56 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49481 461
Crl:CD(SD) heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 10 15.05 % 4.75 15.03 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49856 461
Crl:CD(SD) body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 10 251.5 g 4.4 14.0 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50081 461
Crl:CD(SD) serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 9 8.5 mg/dl 0.24 0.72 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38836 401
Crl:CD(SD) hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 9 44.7 % 0.55 1.65 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38864 401
Crl:CD(SD) serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 9 0.17 mg/dl 0.02 0.05 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42177 401
Crl:CD(SD) mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 33.2 g/dl 0.24 0.73 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42212 401
Crl:CD(SD) serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 9 4.43 mmol/l 0.13 0.39 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39096 401
Crl:CD(SD) serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 9 2.28 g/dl 0.12 0.35 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39216 401
Crl:CD(SD) serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 9 140.44 mmol/l 0.5 1.51 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39339 401
Crl:CD(SD) serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 9 4.54 g/dl 0.07 0.22 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39351 401
Crl:CD(SD) total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 9 7.54 x 1000 cells/ul 0.49 1.46 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39493 401
Crl:CD(SD) plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 9 0.3 mg/dl 0.02 0.05 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39555 401
Crl:CD(SD) mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 32.72 g/dl 0.15 0.45 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42733 401
Crl:CD(SD) total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 9 6.48 x 1000 cells/ul 0.53 1.58 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42855 401
Crl:CD(SD) percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 155.49 % 5.63 20.29 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54539 381
Crl:CD(SD) percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 138.28 % 7.69 25.51 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53595 381
Crl:CD(SD) percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 101.9 % 3.47 12.51 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53613 381
Crl:CD(SD) serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 9 1.97 g/dl 0.08 0.23 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39978 401
Crl:CD(SD) serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 9 2.09 g/dl 0.1 0.29 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39980 401
Crl:CD(SD) blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 9 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40503 401
Crl:CD(SD) mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 9 53.87 fl 0.58 1.75 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37789 401
Crl:CD(SD) serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 9 4.49 g/dl 0.1 0.29 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41135 401
Crl:CD(SD) serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 9 9.34 mg/dl 0.19 0.57 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37928 401
Crl:CD(SD) blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 9 4.6 x 1000 cells/ul 0.43 1.29 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37938 401
Crl:CD(SD) mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 18.91 pg 0.15 0.45 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41276 401
Crl:CD(SD) red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 9 8.68 x 10E6 cells/ul 0.26 0.78 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38153 401
Crl:CD(SD) blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 9 5.76 x 1000 cells/ul 0.38 1.15 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38218 401
Crl:CD(SD) serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 9 55.0 U/l 3.34 10.01 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38615 401
Crl:CD(SD) methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 5.28 ml/min/kg 0.14 0.41 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57451 526
Crl:CD(SD) FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 26.0 ml/min/kg 2.1 6.3 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57461 526
Crl:CD(SD) lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 10 1.03 g/kg 0.05 0.15 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57575 526
Crl:CD(SD) calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57683 526
Crl:CD(SD) calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57685 526
Crl:CD(SD) body weight control condition (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 10 247.2 g 8.1 25.6 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57705 526
Crl:CD(SD) partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 26.54 mmHg 1.24 3.27 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16367 381
Crl:CD(SD) fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 10 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58086 526
Crl:CD(SD) body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 14 231.4 g 7.9 29.5 whole body digital scale Moms and pups used in studies were fed Dyets 16791 381
Crl:CD(SD) maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 20 1.57 g/mg 0.07 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55861 522
Crl:CD(SD) methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 8.25 ml/min/kg 0.3 0.84 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58308 526
Crl:CD(SD) heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 10 0.23 null 0.01 0.03 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58442 526
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 40.67 % 5.16 21.89 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56046 522
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 19 43.58 % 4.62 20.14 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56048 522
Crl:CD(SD) methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 0.22 null 0.03 0.1 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58576 526
Crl:CD(SD) methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 0.26 null 0.02 0.05 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58574 526
Crl:CD(SD) concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 19 0.03 10E-7mol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56456 522
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 19 64.16 % 3.85 16.77 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56685 522
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 61.39 % 4.13 17.53 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56683 522
Crl:CD(SD) body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 15 228.3 g 5.5 21.5 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60100 526
Crl:CD(SD) body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 10 312.9 g 7.4 23.4 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60098 526
Crl:CD(SD) dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 9 1.82 mg/kg 0.44 1.32 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60110 526
Crl:CD(SD) FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 45.0 ml/min/kg 7.34 23.21 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60132 526
Crl:CD(SD) maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 1.22 g/mg 0.11 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56863 522
Crl:CD(SD) percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 52.16 % 2.18 6.55 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45854 461
Crl:CD(SD) arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 9 13.27 ml/min/g 1.12 3.36 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46154 461
Crl:CD(SD) body weight control condition PhysGen Cardiac data body mass male 49.0 days-63.0 days 10 269.5 g 9.5 30.1 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47161 461
Crl:CD(SD) body weight control condition PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 183.8 g 6.7 21.3 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47163 461
Crl:CD(SD) time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 831.13 s 52.0 164.45 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48120 461
Crl:CD(SD) left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 5.5 mmHg 0.1 0.28 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48160 461
Crl:CD(SD) heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 268.08 beats/min 8.94 26.82 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48172 461
Crl:CD(SD) time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 1139.63 s 43.43 137.34 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45103 461
Crl:CD(SD) left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 31.89 mmHg 7.44 19.68 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47407 461
Crl:CD(SD) heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 9 0.45 IU/g 0.25 0.74 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48379 461
Crl:CD(SD) heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 7 0.19 IU/g 0.07 0.19 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45232 461
Crl:CD(SD) heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 250.21 beats/min 6.3 17.81 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45356 461
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 168.0 days 19 48.1 U/l 0.69 3.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85425 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147.0 days 8 17.9 g/d 1.77 5.0 unspecified method 0.0 85480 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147.0 days 8 4.37 g/d/100g 0.23 0.66 unspecified method 0.0 on days 74-77 85510 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168.0 days 8 3.96 g/d/100g 0.35 0.98 unspecified method 0.0 on days 95-98 85516 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126.0 days 19 20.1 g/d 0.5 2.2 unspecified method 0.0 85295 1604
Crl:CD(SD) food intake rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168.0 days 19 23.7 g/d 0.48 2.1 unspecified method 0.0 85298 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168.0 days 19 17.2 g/d 0.83 3.6 unspecified method 0.0 85299 1604
Crl:CD(SD) body weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 71.0 days 19 373.0 g 4.59 20.0 body weighing method 0.0 85310 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 105.0 days 19 374.0 g 5.28 23.0 body weighing method 0.0 85315 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 168.0 days 19 444.0 g 6.65 29.0 body weighing method 0.0 85321 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 133.0 days 19 134.0 mg/dl 1.15 5.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85332 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 78.0 days 19 130.0 mg/dl 1.84 8.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85324 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 70.0 days 19 20.5 mg/dl 1.81 7.9 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85354 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 119.0 days 19 33.2 mg/dl 3.4 14.8 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85363 1604
Crl:CD(SD) plasma creatinine level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 105.0 days 19 0.38 mg/dl 0.0 0.02 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85372 1604
Crl:CD(SD) urine creatinine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 134.0 days 19 16.46 mg/d 0.22 0.97 liquid chromatography-mass spectrometry 0.0 85390 1604
Crl:CD(SD) urine taurine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 106.0 days 19 137.6 umol/d 8.44 36.8 liquid chromatography-mass spectrometry 0.0 85396 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 91.0 days 19 59.7 U/l 0.8 3.5 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85415 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 70.0 days 19 32.5 U/l 0.71 3.1 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85426 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 105.0 days 19 34.0 U/l 1.35 5.9 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85433 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 147.0 days 19 13.4 U/l 0.41 1.8 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85455 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 119.0 days 19 15.0 U/l 0.55 2.4 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85451 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (500 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84.0 days 8 5.68 g/d/100g 0.06 0.17 unspecified method 0.0 on days 11-14 85490 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126.0 days 8 4.38 g/d/100g 0.31 0.87 unspecified method 0.0 on days 53-56 85504 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126.0 days 8 4.23 g/d/100g 0.27 0.77 unspecified method 0.0 on days 53-56 85505 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 105.0 days 8 375.0 g 12.73 36.0 body weighing method 0.0 85534 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 84.0 days 8 321.0 g 7.78 22.0 body weighing method 0.0 85529 1604
Crl:CD(SD) body weight standard diet then acetaminophen (300 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 147.0 days 8 557.0 g 8.13 23.0 body weighing method 0.0 85543 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 126.0 days 8 400.0 g 7.78 22.0 body weighing method 0.0 85541 1604
Crl:CD(SD) body weight standard diet then acetaminophen (300 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 126.0 days 8 522.0 g 8.13 23.0 body weighing method 0.0 85537 1604
Crl:CD(SD) liver wet weight standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver mass male 170.0 days 8 12.8 g 0.22 0.61 unspecified method 0.0 85559 1604
Crl:CD(SD) liver reduced glutathione level to liver weight ratio standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170.0 days 8 5.19 umol/g 0.24 0.69 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 enzyme recycling method 85571 1604
Crl:CD(SD) blood urea nitrogen level control condition O'Meara CC, et al., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5. blood urea nitrogen amount male 189.0 days 6 22.33 mg/dl 1.53 3.75 automated blood analysis 0.0 ACE Autoanalyzer Clinical Chemistry System 96906 1738
Crl:CD(SD) plasma creatinine level control condition O'Meara CC, et al., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5. blood creatinine amount male 189.0 days 6 0.47 mg/dl 0.03 0.07 automated blood analysis 0.0 ACE Autoanalyzer Clinical Chemistry System 96916 1738
Crl:CD(SD) post-insult time to mammary tumor formation maternal milk (for 20 days) and vehicle control condition (for 15 days) then 7,12-dimethyltetraphene (30 mg/kg) (for 1 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. mammary gland integrity trait female  days-365.0 days 32 median 65.0 d manual palpation method 0.0 76267 1558
Crl:CD(SD) post-insult time to mammary tumor formation maternal milk (for 20 days) and bisphenol A (25 ug/kg) (for 15 days) then 7,12-dimethyltetraphene (30 mg/kg) (for 1 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. mammary gland integrity trait female  days-365.0 days 34 median 53.0 d manual palpation method 0.0 76268 1558
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 119.0 days 19 0.61 mg/dl 0.02 0.08 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85346 1604
Crl:CD(SD) urine creatinine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 70.0 days 19 7.64 mg/d 0.27 1.17 liquid chromatography-mass spectrometry 0.0 85387 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168.0 days 19 4.01 g/d/100g 0.27 1.17 unspecified method 0.0 85309 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 84.0 days 19 328.0 g 4.82 21.0 body weighing method 0.0 85313 1604
Crl:CD(SD) body weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 168.0 days 19 588.0 g 14.45 63.0 body weighing method 0.0 85320 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 168.0 days 19 131.0 mg/dl 1.61 7.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85336 1604
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 105.0 days 19 0.49 mg/dl 0.02 0.1 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85344 1604
Crl:CD(SD) urine creatine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 169.0 days 19 2.06 umol/d 0.12 0.51 liquid chromatography-mass spectrometry 0.0 85385 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 133.0 days 19 57.6 U/l 1.58 6.9 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85421 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 168.0 days 19 37.3 U/l 0.96 4.2 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85440 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 70.0 days 19 15.9 U/l 1.17 5.1 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85443 1604
Crl:CD(SD) serum estradiol level maternal milk (for 20 days) and bisphenol A (250 ug/kg) (for 15 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. blood estradiol amount female 50.0 days 24 23.6 pg/ml 4.7 23.03 radioimmunoassay 0.0 76261 1558
Crl:CD(SD) serum progesterone level maternal milk (for 20 days) and bisphenol A (250 ug/kg) (for 15 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. blood progesterone amount female 50.0 days 24 9.9 ng/ml 1.9 9.31 radioimmunoassay 0.0 76263 1558
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 168.0 days 19 52.7 U/l 1.26 5.5 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85424 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 147.0 days 19 54.3 U/l 1.26 5.5 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85423 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147.0 days 8 4.03 g/d/100g 0.29 0.81 unspecified method 0.0 on days 74-77 85511 1604
Crl:CD(SD) liver oxidized glutathione level to liver weight ratio standard diet then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170.0 days 8 0.24 umol/g 0.01 0.02 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 enzyme recycling method reduced liver glutathione level to liver weight ratio 85573 1604
Crl:CD(SD) retinal outer layer thickness AMG-8718 (100 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 138.5 um 4.25 9.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105484 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (600 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 133.4 um 3.04 6.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105485 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 118.6 um 3.35 7.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105493 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (600 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 122.4 um 4.65 10.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105489 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (10 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 59.0 days-66.0 days 5 40.8 um 1.25 2.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105435 3016
Crl:CD(SD) full retina thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 81.0 days-88.0 days 5 177.2 um 6.22 13.9 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105446 3016
Crl:CD(SD) retinal outer nuclear layer thickness vehicle control condition (0 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 59.0 days-66.0 days 5 41.0 um 1.12 2.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105434 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (600 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 132.4 um 3.44 7.7 optical coherence tomography 0.0 optical coherence tomography outer retinal layer 105469 3016
Crl:CD(SD) retinal outer nuclear layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 53.4 um 2.33 5.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105442 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 124.3 um 3.44 7.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105500 3016
Crl:CD(SD) plasma AMG-8718 maximum concentration AMG-8718 (600 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 39900.0 ng/ml 2575.95 5760.0 liquid chromatography-mass spectrometry 0.0 max conc 105424 3016
Crl:CD(SD) full retina thickness vehicle control condition (0 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 129.7 um 3.71 8.3 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105438 3016
Crl:CD(SD) full retina thickness AMG-8718 (100 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 122.2 um 4.07 9.1 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105440 3016
Crl:CD(SD) full retina thickness AMG-8718 (600 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 137.1 um 18.02 40.3 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105441 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (10 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 129.9 um 3.71 8.3 optical coherence tomography 0.0 optical coherence tomography inner retinal layer 105471 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 131.6 um 4.87 10.9 optical coherence tomography 0.0 optical coherence tomography inner retinal layer 105470 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (600 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 129.6 um 4.2 9.4 optical coherence tomography 0.0 optical coherence tomography inner retinal layer 105473 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 128.7 um 4.92 11.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105478 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 120.4 um 4.25 9.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105505 3016
Crl:CD(SD) mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 110.69 mmHg 6.18 18.54 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15797 381
Crl:CD(SD) partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 9 33.19 mmHg 1.47 4.41 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15364 381
Crl:CD(SD) percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 %change=VE during 2-3 min hypercapnia/control during standard conditions 242.68 % 10.9 39.31 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14400 381
Crl:CD(SD) percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 %change=VE during 2-3 min hypercapnia/control during standard conditions 258.91 % 12.22 40.52 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14402 381
Crl:CD(SD) tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.36 ml 0.02 0.07 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14431 381
Crl:CD(SD) tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.29 ml 0.02 0.06 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14433 381
Crl:CD(SD) urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 9 25.23 mg/d 4.32 12.97 automated urine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 52060 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 -23.93 beats/min 10.03 22.42 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 52068 481
Crl:CD(SD) heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 420.92 beats/min 8.61 17.21 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50863 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -76.42 beats/min 10.6 21.21 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50867 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 5.44 beats/min 14.96 29.92 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50891 481
Crl:CD(SD) percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 101.48 % 3.3 10.95 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54191 381
Crl:CD(SD) percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 96.12 % 1.49 5.36 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54198 381
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 5 -2.18 mmHg 2.36 5.28 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51067 481
Crl:CD(SD) creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 3 1.5 ml/min 0.2 0.34 urine creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51258 481
Crl:CD(SD) creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 6 2.46 ml/min 0.22 0.54 urine creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51256 481
Crl:CD(SD) mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 109.0 mmHg 4.18 8.37 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51390 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 16.77 mmHg 3.57 9.46 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51417 481
Crl:CD(SD) plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 6 1.14 ng/ml/h 0.3 0.74 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51603 481
Crl:CD(SD) plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 5 1.32 ng/ml/h 0.64 1.42 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51605 481
Crl:CD(SD) heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 373.44 beats/min 16.24 42.96 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51618 481
Crl:CD(SD) plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 5 5.64 ng/ml/h 1.41 3.16 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50413 481
Crl:CD(SD) respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 104.9 breaths/min 4.56 15.14 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17326 381
Crl:CD(SD) tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.32 ml 0.02 0.08 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14012 381
Crl:CD(SD) percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 170.11 % 9.72 32.22 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53849 381
Crl:CD(SD) percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 159.51 % 6.11 22.01 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53856 381
Crl:CD(SD) body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 13 37.45 degrees C 0.1 0.35 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19992 381
Crl:CD(SD) heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 386.27 beats/min 10.38 29.36 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19540 381
Crl:CD(SD) heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 424.94 beats/min 13.33 39.99 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19542 381
Crl:CD(SD) minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 101.9 ml/min 6.93 24.99 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19587 381
Crl:CD(SD) minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 88.89 ml/min 6.92 22.94 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19589 381
Crl:CD(SD) respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 149.87 breaths/min 6.13 22.11 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17558 381
Crl:CD(SD) respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 205.62 breaths/min 16.24 53.87 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17959 381
Crl:CD(SD) blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18094 381
Crl:CD(SD) serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 9 6.77 g/dl 0.14 0.43 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36265 401
Crl:CD(SD) blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 9 1.47 x 1000 cells/ul 0.14 0.43 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36299 401
Crl:CD(SD) serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 9 62.33 mg/dl 5.12 15.37 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36466 401
Crl:CD(SD) absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 7 0.63 degrees C 0.19 0.51 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18511 381
Crl:CD(SD) red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 9 7.97 x 10E6 cells/ul 0.17 0.5 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36574 401
Crl:CD(SD) serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 9 8.22 mg/dl 0.22 0.66 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36719 401
Crl:CD(SD) blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 6 7.44 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19319 381
Crl:CD(SD) respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 182.36 breaths/min 9.37 31.09 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20179 381
Crl:CD(SD) absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 13 -0.08 degrees C 0.19 0.69 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19156 381
Crl:CD(SD) time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 943.5 s 95.47 301.9 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49483 461
Crl:CD(SD) percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 67.51 % 6.43 20.33 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49653 461
Crl:CD(SD) percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 58.7 % 10.36 32.75 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49655 461
Crl:CD(SD) serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 9 162.67 U/l 11.46 34.38 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42350 401
Crl:CD(SD) serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 9 3.79 g/dl 0.05 0.15 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39349 401
Crl:CD(SD) serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 8 9.6 mg/dl 0.13 0.36 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42522 401
Crl:CD(SD) blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 15.06 g/dl 0.27 0.81 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42743 401
Crl:CD(SD) calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 0.11 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59039 526
Crl:CD(SD) serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 9 0.21 mg/dl 0.01 0.03 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37543 401
Crl:CD(SD) mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 9 56.93 fl 0.62 1.85 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37791 401
Crl:CD(SD) serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 8 18.63 mmol/l 0.56 1.6 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41123 401
Crl:CD(SD) serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 9 15.89 mmol/l 0.77 2.32 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41125 401
Crl:CD(SD) mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 9 17.52 pg 0.19 0.58 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41274 401
Crl:CD(SD) serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 9 248.78 U/l 19.94 59.82 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38172 401
Crl:CD(SD) blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 9 5.06 x 1000 cells/ul 0.68 2.04 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38216 401
Crl:CD(SD) serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 9 141.33 mmol/l 0.53 1.58 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38238 401
Crl:CD(SD) serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 9 48.78 U/l 4.25 12.74 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41602 401
Crl:CD(SD) serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 9 102.67 U/l 6.89 20.66 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41612 401
Crl:CD(SD) blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 9 18.49 g/dl 0.24 0.73 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38401 401
Crl:CD(SD) blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 16.86 g/dl 0.43 1.3 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38403 401
Crl:CD(SD) heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 332.0 beats/min 62.39 197.29 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46501 461
Crl:CD(SD) percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 25.51 % 8.58 27.14 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47524 461
Crl:CD(SD) percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 94.12 % 2.29 6.87 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47542 461
Crl:CD(SD) left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 130.92 mmHg 5.55 17.56 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47666 461
Crl:CD(SD) concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 0.05 umol/l 0.02 0.07 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57429 522
Crl:CD(SD) left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 142.0 mmHg 4.41 13.24 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47668 461
Crl:CD(SD) FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 39.38 ml/min/kg 3.04 8.6 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57463 526
Crl:CD(SD) logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 -8.19 null 0.1 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55346 522
Crl:CD(SD) logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 19 -8.68 null 0.07 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55348 522
Crl:CD(SD) fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 7 0.08 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57695 526
Crl:CD(SD) heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 419.01 beats/min 16.51 40.43 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16430 381
Crl:CD(SD) absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 0.08 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16669 381
Crl:CD(SD) concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 1.75 E-7mole 0.27 0.86 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55982 522
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 20 30.5 % 3.58 16.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54641 522
Crl:CD(SD) logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 -6.84 null 0.09 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54745 522
Crl:CD(SD) hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 9 56.52 % 0.73 2.19 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58584 526
Crl:CD(SD) body weight control condition (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 20 263.6 g 3.2 14.5 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54873 522
Crl:CD(SD) logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 -8.48 null 0.05 0.16 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55115 522
Crl:CD(SD) acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 20 48.75 % 5.17 23.13 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56751 522
Crl:CD(SD) concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 1.53 E-7mole 0.26 1.09 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56798 522
Crl:CD(SD) concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 19 1.11 E-7mole 0.19 0.82 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56800 522
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 43.25 % 7.16 20.26 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56827 522
Crl:CD(SD) dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 7 2.02 mg/kg 0.47 1.24 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60108 526
Crl:CD(SD) maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 1.47 g/mg 0.1 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56865 522
Crl:CD(SD) tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.3 ml 0.02 0.07 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16036 381
Crl:CD(SD) arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 5.57 ml/min/g 0.28 0.84 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45891 461
Crl:CD(SD) left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 56.35 mmHg 5.11 16.17 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45933 461
Crl:CD(SD) percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 63.54 % 2.82 8.92 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47884 461
Crl:CD(SD) left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 5.73 mmHg 0.11 0.35 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48008 461
Crl:CD(SD) left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 5.3 mmHg 0.12 0.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48010 461
Crl:CD(SD) arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 9.37 ml/min/g 0.51 1.62 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46176 461
Crl:CD(SD) heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 276.52 beats/min 8.41 23.79 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48174 461
Crl:CD(SD) heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 1.27 g 0.04 0.13 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45030 461
Crl:CD(SD) time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 1197.3 s 78.37 247.83 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45068 461
Crl:CD(SD) time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 1257.86 s 68.22 215.74 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45066 461
Crl:CD(SD) arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 14.76 ml/min/g 0.5 1.58 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45083 461
Crl:CD(SD) heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 7 0.28 IU/g 0.07 0.19 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45234 461
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 147.0 days 19 36.4 U/l 0.62 2.7 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85438 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (500 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105.0 days 8 25.7 g/d 0.28 0.8 unspecified method 0.0 85466 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (300 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126.0 days 8 24.6 g/d 0.21 0.6 unspecified method 0.0 85471 1604
Crl:CD(SD) body weight standard diet then acetaminophen (500 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 84.0 days 8 413.0 g 6.01 17.0 body weighing method 0.0 85526 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 168.0 days 8 447.0 g 16.62 47.0 body weighing method 0.0 85552 1604
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 70.0 days 19 0.54 mg/dl 0.03 0.15 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85338 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 133.0 days 19 17.4 mg/dl 0.85 3.7 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85364 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 119.0 days 19 19.8 mg/dl 0.87 3.8 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85362 1604
Crl:CD(SD) plasma creatinine level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 105.0 days 19 0.41 mg/dl 0.01 0.03 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85373 1604
Crl:CD(SD) urine creatinine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 106.0 days 19 13.78 mg/d 0.28 1.21 liquid chromatography-mass spectrometry 0.0 85388 1604
Crl:CD(SD) liver oxidized glutathione level to liver weight ratio standard diet and restricted feeding (4 h) (for 114 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170.0 days 19 0.17 umol/g 0.0 0.02 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 enzyme recycling method 85409 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 70.0 days 19 61.8 U/l 1.26 5.5 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85411 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 91.0 days 19 35.4 U/l 1.49 6.5 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85431 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84.0 days 8 20.3 g/d 1.06 3.0 unspecified method 0.0 85462 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (300 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105.0 days 8 5.2 g/d/100g 0.07 0.21 unspecified method 0.0 on days 32-35 85495 1604
Crl:CD(SD) body weight standard diet then acetaminophen (300 mg/kg) (for 1 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 71.0 days 8 371.0 g 5.66 16.0 body weighing method 0.0 85519 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (500 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147.0 days 8 4.49 g/d/100g 0.08 0.23 unspecified method 0.0 on days 74-77 85508 1604
Crl:CD(SD) body weight standard diet then acetaminophen (500 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 126.0 days 8 516.0 g 12.73 36.0 body weighing method 0.0 85538 1604
Crl:CD(SD) mean arterial blood pressure control condition O'Meara CC, et al., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5. arterial blood pressure trait male 189.0 days 6 serial mean 93.0 mmHg 5.0 12.25 vascular indwelling catheter method femoral artery 10800.0 1day/week 96901 1738
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 133.0 days 19 0.91 mg/dl 0.1 0.43 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85349 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 119.0 days 19 0.94 mg/dl 0.09 0.39 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85347 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147.0 days 19 4.18 g/d/100g 0.19 0.84 unspecified method 0.0 85307 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84.0 days 19 6.11 g/d/100g 0.1 0.45 unspecified method 0.0 85301 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 105.0 days 19 129.0 mg/dl 1.38 6.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85328 1604
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 91.0 days 19 0.62 mg/dl 0.01 0.05 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85342 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 147.0 days 19 0.68 mg/dl 0.1 0.42 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85351 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 91.0 days 19 25.2 mg/dl 2.09 9.1 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85359 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 105.0 days 19 23.5 mg/dl 2.29 10.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85361 1604
Crl:CD(SD) plasma creatinine level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 133.0 days 19 0.37 mg/dl 0.0 0.02 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85374 1604
Crl:CD(SD) urine creatine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 169.0 days 19 2.11 umol/d 0.11 0.48 liquid chromatography-mass spectrometry 0.0 85384 1604
Crl:CD(SD) plasma creatinine level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 133.0 days 19 0.41 mg/dl 0.01 0.04 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85375 1604
Crl:CD(SD) liver wet weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver mass male 170.0 days 19 17.65 g 0.54 2.35 unspecified method 0.0 liver weight not available 85402 1604
Crl:CD(SD) liver wet weight standard diet and restricted feeding (4 h) (for 114 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver mass male 170.0 days 19 11.09 g 0.16 0.71 unspecified method 0.0 85403 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 147.0 days 19 55.4 U/l 2.25 9.8 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85422 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 91.0 days 19 33.3 U/l 0.87 3.8 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85430 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 168.0 days 19 33.2 U/l 1.1 4.8 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85441 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 119.0 days 19 14.8 U/l 0.89 3.9 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85450 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105.0 days 8 4.9 g/d/100g 0.18 0.5 unspecified method 0.0 on days 32-35 85499 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168.0 days 8 4.34 g/d/100g 0.34 0.96 unspecified method 0.0 on days 95-98 85517 1604
Crl:CD(SD) mammary tumor number maternal milk (for 20 days) and vehicle control condition (for 15 days) then 7,12-dimethyltetraphene (30 mg/kg) (for 1 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. mammary gland integrity trait female  days-365.0 days 32 2.84 null 0.31 1.75 manual palpation method 0.0 76264 1558
Crl:CD(SD) mammary tumor number maternal milk (for 20 days) and bisphenol A (250 ug/kg) (for 15 days) then 7,12-dimethyltetraphene (30 mg/kg) (for 1 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. mammary gland integrity trait female  days-365.0 days 24 5.0 null 0.88 4.31 manual palpation method 0.0 76266 1558
Crl:CD(SD) liver reduced glutathione level to liver weight ratio standard diet then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170.0 days 8 9.16 umol/g 0.18 0.5 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 enzyme recycling method reduced liver glutathione level to liver weight ratio 85567 1604
Crl:CD(SD) plasma acetaminophen level standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170.0 days 8 49.3 ug/ml 5.62 15.9 high-performance liquid chromatography 0.0 acetaminophen dosing 240 min 4 hr after dosing 85580 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 105.0 days 19 13.5 U/l 0.21 0.9 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85449 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 147.0 days 8 432.0 g 17.32 49.0 body weighing method 0.0 85546 1604
Crl:CD(SD) blood urea nitrogen level control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. blood urea nitrogen amount male 112.0 days 5 19.3 mg/dl 2.6 5.81 blood urea nitrogen analysis 0.0 100764 2521
Crl:CD(SD) urine total protein excretion rate control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. total urine protein amount male 112.0 days 5 36.7 mg/d 3.5 7.83 urine protein analysis 0.0 100768 2521
Crl:CD(SD) plasma AMG-8718 maximum concentration AMG-8718 (10 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 2730.0 ng/ml 287.11 642.0 liquid chromatography-mass spectrometry 0.0 max conc 105422 3016
Crl:CD(SD) plasma AMG-8718 level area under curve (AUC) AMG-8718 (600 mg/kg) (for 24 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 81.0 days-88.0 days 5 671000.0 ng/ml/h 84076.16 188000.0 liquid chromatography-mass spectrometry 0.0 samples at 0.5, 1.5, 5, 10, 24 hours auc 105433 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 55.6 um 1.25 2.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105444 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 52.5 um 2.33 5.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105443 3016
Crl:CD(SD) full retina thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 81.0 days-88.0 days 5 175.9 um 9.17 20.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105447 3016
Crl:CD(SD) full retina thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 81.0 days-88.0 days 5 175.7 um 16.14 36.1 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105449 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 8.4 null 0.49 1.1 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105465 3016
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 138.5 um 3.4 7.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105474 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (10 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 137.0 um 3.44 7.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105483 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count vehicle control condition (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 10.5 null 0.4 0.9 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105462 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 10.1 null 0.4 0.9 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105464 3016
Crl:CD(SD) full retina thickness AMG-8718 (10 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 128.0 um 4.74 10.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105439 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 11.3 null 0.37 0.83 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105450 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 51.1 um 1.65 3.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105455 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 10.5 null 0.42 0.95 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105453 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (100 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 128.6 um 4.11 9.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105480 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 121.9 um 4.38 9.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105494 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 122.6 um 4.74 10.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105504 3016
Crl:CD(SD) minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 41.88 ml/min 1.7 6.14 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15490 381
Crl:CD(SD) heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 526.73 beats/min 9.55 25.27 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15786 381
Crl:CD(SD) mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 120.64 mmHg 1.65 4.68 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15795 381
Crl:CD(SD) percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 %change=VE during7-9 min hypercapnia/control during standard conditions 244.93 % 11.05 39.83 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15210 381
Crl:CD(SD) creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 5 1.19 ml/min 0.22 0.48 urine creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51685 481
Crl:CD(SD) mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 108.62 mmHg 3.76 9.22 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51731 481
Crl:CD(SD) plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 6 0.32 mg/dl 0.02 0.05 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51984 481
Crl:CD(SD) plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 3 0.33 mg/dl 0.02 0.03 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51986 481
Crl:CD(SD) urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87.0 days-120.0 days 8 17.51 mg/d 3.98 11.26 automated urine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 52062 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 3.0 mmHg 3.86 7.72 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50542 481
Crl:CD(SD) heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 402.53 beats/min 6.39 15.65 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50576 481
Crl:CD(SD) heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 384.12 beats/min 4.27 11.3 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50853 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 35.66 mmHg 2.83 6.34 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50873 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 35.88 mmHg 3.36 8.9 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50875 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -15.09 beats/min 14.75 39.03 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51036 481
Crl:CD(SD) percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 159.5 % 8.93 32.21 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54176 381
Crl:CD(SD) percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 156.11 % 9.9 32.84 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54180 381
Crl:CD(SD) percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 152.39 % 4.77 17.21 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54187 381
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 -3.09 mmHg 3.77 9.23 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51065 481
Crl:CD(SD) mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 113.23 mmHg 1.95 5.15 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51076 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 -9.38 beats/min 20.13 45.01 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51330 481
Crl:CD(SD) urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 1.68 mEq/d 0.25 0.74 flame atomic emission spectrometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51364 481
Crl:CD(SD) urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 9 1.82 mEq/d 0.27 0.81 flame atomic emission spectrometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51362 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 1.67 beats/min 21.69 57.39 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51531 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 4.15 beats/min 23.97 47.94 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51673 481
Crl:CD(SD) mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 109.1 mmHg 3.86 10.21 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50351 481
Crl:CD(SD) mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 121.24 mmHg 5.98 16.92 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13451 381
Crl:CD(SD) absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 5 -1.95 mmHg 0.95 2.12 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17198 381
Crl:CD(SD) percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 %change=VE during7-9 min hypoxia/control during standard conditions 123.49 % 5.27 18.99 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17335 381
Crl:CD(SD) absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 -0.36 degrees C 0.3 0.99 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13869 381
Crl:CD(SD) mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 109.25 mmHg 8.69 26.06 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13880 381
Crl:CD(SD) tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.36 ml 0.03 0.1 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14010 381
Crl:CD(SD) blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 5 7.46 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14045 381
Crl:CD(SD) partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 6 96.2 mmHg 3.67 8.98 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14077 381
Crl:CD(SD) minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 54.74 ml/min 3.92 14.14 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19718 381
Crl:CD(SD) body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 13 37.53 degrees C 0.22 0.79 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19943 381
Crl:CD(SD) absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 9.47 mmHg 2.86 7.57 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20107 381
Crl:CD(SD) absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 5 -44.6 mmHg 4.41 9.85 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20688 381
Crl:CD(SD) absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 -51.54 mmHg 2.2 5.82 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20690 381
Crl:CD(SD) respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 143.38 breaths/min 7.28 24.15 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17560 381
Crl:CD(SD) body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 38.13 degrees C 0.23 0.77 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17784 381
Crl:CD(SD) minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 31.28 ml/min 1.95 6.47 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17906 381
Crl:CD(SD) respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 188.17 breaths/min 5.03 18.15 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17957 381
Crl:CD(SD) partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 54.5 mmHg 1.38 3.65 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17010 381
Crl:CD(SD) absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 6 0.32 degrees C 0.18 0.43 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18509 381
Crl:CD(SD) body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 6 37.95 degrees C 0.21 0.52 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18802 381
Crl:CD(SD) body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 7 38.23 degrees C 0.09 0.23 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18804 381
Crl:CD(SD) hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 9 51.56 % 1.43 4.29 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36348 401
Crl:CD(SD) serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 9 93.22 U/l 8.4 25.2 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37426 401
Crl:CD(SD) serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 9 89.78 U/l 3.79 11.38 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37424 401
Crl:CD(SD) tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.36 ml 0.03 0.11 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19038 381
Crl:CD(SD) tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.3 ml 0.02 0.07 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19040 381
Crl:CD(SD) tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.44 ml 0.03 0.1 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18522 381
Crl:CD(SD) percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 144.67 % 8.05 26.69 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19304 381
Crl:CD(SD) respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 120.91 breaths/min 5.12 16.98 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18159 381
Crl:CD(SD) respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 189.18 breaths/min 11.23 40.47 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20177 381
Crl:CD(SD) heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 5.46 g/kg 0.15 0.47 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49147 461
Crl:CD(SD) heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 47.1 mmHg 2.59 8.18 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49591 461
Crl:CD(SD) heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 4.5 g/kg 0.24 0.76 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49669 461
Crl:CD(SD) left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 98.3 mmHg 9.41 26.61 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49784 461
Crl:CD(SD) left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 99.6 mmHg 3.83 11.5 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49782 461
Crl:CD(SD) heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 10 7.16 % 4.64 14.66 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49858 461
Crl:CD(SD) body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 190.4 g 7.4 23.4 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50083 461
Crl:CD(SD) hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 9 45.39 % 1.01 3.02 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38866 401
Crl:CD(SD) mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 9 32.53 g/dl 0.09 0.27 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42210 401
Crl:CD(SD) serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 9 246.67 U/l 20.24 60.73 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42348 401
Crl:CD(SD) serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 9 139.22 mmol/l 0.83 2.49 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39341 401
Crl:CD(SD) serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 9 9.7 mg/dl 0.09 0.26 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42524 401
Crl:CD(SD) total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 9 6.56 x 1000 cells/ul 0.72 2.17 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39491 401
Crl:CD(SD) serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 8 20.25 mg/dl 0.96 2.71 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39513 401
Crl:CD(SD) serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 9 23.78 mmol/l 0.43 1.3 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43070 401
Crl:CD(SD) percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 156.59 % 9.05 30.0 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54532 381
Crl:CD(SD) calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 7 0.08 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59041 526
Crl:CD(SD) serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 9 159.67 mg/dl 5.17 15.52 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40489 401
Crl:CD(SD) serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 9 169.0 mg/dl 6.0 18.01 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40487 401
Crl:CD(SD) blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 9 0.07 x 1000 cells/ul 0.02 0.05 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40505 401
Crl:CD(SD) serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 9 4.42 mmol/l 0.1 0.31 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40647 401
Crl:CD(SD) serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 9 4.28 mmol/l 0.11 0.34 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40649 401
Crl:CD(SD) blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 9 0.4 x 1000 cells/ul 0.1 0.3 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40691 401
Crl:CD(SD) blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 9 0.38 x 1000 cells/ul 0.09 0.26 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40693 401
Crl:CD(SD) plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 8 21.5 mmol/l 0.6 1.69 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37553 401
Crl:CD(SD) plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 9 23.0 mmol/l 0.76 2.29 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37555 401
Crl:CD(SD) serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 9 3.78 g/dl 0.05 0.16 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41133 401
Crl:CD(SD) serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 9 90.11 mg/dl 4.54 13.62 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37909 401
Crl:CD(SD) serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 9 136.0 U/l 13.84 41.52 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38174 401
Crl:CD(SD) serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 9 106.33 mmol/l 0.47 1.41 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38182 401
Crl:CD(SD) serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 9 140.0 mmol/l 0.91 2.74 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38240 401
Crl:CD(SD) blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 9 0.07 x 1000 cells/ul 0.01 0.04 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38348 401
Crl:CD(SD) percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 90.89 % 2.83 8.01 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47544 461
Crl:CD(SD) acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 50.88 % 8.31 23.49 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55384 522
Crl:CD(SD) fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 8 0.08 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57693 526
Crl:CD(SD) methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 0.26 null 0.04 0.12 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57735 526
Crl:CD(SD) methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 0.22 null 0.02 0.05 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57737 526
Crl:CD(SD) dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 8 4.15 mg/kg 1.12 3.16 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57767 526
Crl:CD(SD) partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 5 28.81 mmHg 1.6 3.57 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16365 381
Crl:CD(SD) fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 9 0.05 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58084 526
Crl:CD(SD) maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 20 1.29 g/mg 0.08 0.37 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55859 522
Crl:CD(SD) methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 6.26 ml/min/kg 0.18 0.55 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58306 526
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 22.17 % 2.51 10.63 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54639 522
Crl:CD(SD) hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 9 51.56 % 1.43 4.29 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58586 526
Crl:CD(SD) body weight control condition (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 20 399.8 g 9.9 44.1 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54871 522
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 34.88 % 6.15 17.41 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54999 522
Crl:CD(SD) hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 9 44.7 % 0.55 1.65 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59852 526
Crl:CD(SD) heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 10 0.34 null 0.03 0.09 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59968 526
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 72.0 % 2.58 7.75 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56707 522
Crl:CD(SD) concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 0.05 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56764 522
Crl:CD(SD) logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 19 -7.04 null 0.06 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56776 522
Crl:CD(SD) logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 19 -7.87 null 0.09 0.37 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56817 522
Crl:CD(SD) logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 19 -7.68 null 0.08 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56819 522
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 56.78 % 4.79 14.37 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56829 522
Crl:CD(SD) sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 71.9 % 8.91 28.16 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56853 522
Crl:CD(SD) concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 19 0.02 umol/l 0.0 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56999 522
Crl:CD(SD) concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 19 0.03 umol/l 0.0 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57001 522
Crl:CD(SD) sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 98.33 % 0.65 2.74 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57118 522
Crl:CD(SD) tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.35 ml 0.03 0.11 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16034 381
Crl:CD(SD) percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 59.6 % 6.76 20.29 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45856 461
Crl:CD(SD) left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 34.85 mmHg 9.36 29.59 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45903 461
Crl:CD(SD) left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 43.91 mmHg 11.55 32.66 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45905 461
Crl:CD(SD) percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 67.84 % 7.4 23.42 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47886 461
Crl:CD(SD) left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 118.81 mmHg 6.51 17.21 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46041 461
Crl:CD(SD) arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 10.7 ml/min/g 0.4 1.19 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46152 461
Crl:CD(SD) left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 5.19 mmHg 0.27 0.82 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48158 461
Crl:CD(SD) heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 41.6 mmHg 5.17 16.35 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47383 461
Crl:CD(SD) heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 9 0.2 IU/g 0.05 0.15 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48381 461
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 78.0 days 19 35.0 U/l 1.49 6.5 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85429 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 133.0 days 19 13.4 U/l 0.3 1.3 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85453 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (500 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147.0 days 8 24.5 g/d 0.32 0.9 unspecified method 0.0 85478 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168.0 days 8 16.6 g/d 0.95 2.7 unspecified method 0.0 85487 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 1 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 71.0 days 8 287.0 g 5.3 15.0 body weighing method 0.0 85523 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84.0 days 19 17.0 g/d 0.73 3.2 unspecified method 0.0 85292 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105.0 days 19 17.2 g/d 0.6 2.6 unspecified method 0.0 85293 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126.0 days 19 4.74 g/d/100g 0.11 0.5 unspecified method 0.0 85304 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147.0 days 19 4.44 g/d/100g 0.06 0.28 unspecified method 0.0 85306 1604
Crl:CD(SD) body weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 126.0 days 19 526.0 g 13.31 58.0 body weighing method 0.0 85316 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 147.0 days 19 430.0 g 5.96 26.0 body weighing method 0.0 85319 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 70.0 days 19 0.57 mg/dl 0.04 0.18 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85339 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 78.0 days 19 18.7 mg/dl 1.28 5.6 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85357 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 133.0 days 19 30.2 mg/dl 2.87 12.5 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85365 1604
Crl:CD(SD) plasma creatinine level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 168.0 days 19 0.43 mg/dl 0.0 0.01 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85376 1604
Crl:CD(SD) plasma creatinine level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 168.0 days 19 0.46 mg/dl 0.0 0.02 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85377 1604
Crl:CD(SD) urine creatine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 70.0 days 19 1.67 umol/d 0.05 0.22 liquid chromatography-mass spectrometry 0.0 85378 1604
Crl:CD(SD) urine creatine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 106.0 days 19 2.22 umol/d 0.07 0.31 liquid chromatography-mass spectrometry 0.0 85380 1604
Crl:CD(SD) urine creatine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 70.0 days 19 1.05 umol/d 0.04 0.19 liquid chromatography-mass spectrometry 0.0 85379 1604
Crl:CD(SD) urine creatinine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 134.0 days 19 12.5 mg/d 0.25 1.11 liquid chromatography-mass spectrometry 0.0 85391 1604
Crl:CD(SD) urine taurine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 70.0 days 19 58.1 umol/d 5.41 23.6 liquid chromatography-mass spectrometry 0.0 85395 1604
Crl:CD(SD) urine creatinine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 169.0 days 19 14.95 mg/d 0.54 2.38 liquid chromatography-mass spectrometry 0.0 85392 1604
Crl:CD(SD) liver reduced glutathione level to liver weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170.0 days 19 7.12 umol/g 0.07 0.31 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 enzyme recycling method reduced liver glutathione level to liver weight ratio 85406 1604
Crl:CD(SD) liver reduced glutathione level to liver weight ratio standard diet and restricted feeding (4 h) (for 114 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170.0 days 19 6.1 umol/g 0.15 0.67 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 enzyme recycling method 85407 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 105.0 days 19 58.0 U/l 2.39 10.4 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85416 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 105.0 days 19 58.4 U/l 1.06 4.6 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85417 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (500 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84.0 days 8 24.7 g/d 0.46 1.3 unspecified method 0.0 85460 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105.0 days 8 18.2 g/d 1.13 3.2 unspecified method 0.0 85468 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84.0 days 8 18.8 g/d 0.92 2.6 unspecified method 0.0 85463 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168.0 days 8 18.3 g/d 1.98 5.6 unspecified method 0.0 85486 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 84.0 days 8 333.0 g 8.13 23.0 body weighing method 0.0 85528 1604
Crl:CD(SD) body weight standard diet then acetaminophen (300 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 168.0 days 8 581.0 g 9.19 26.0 body weighing method 0.0 85549 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 126.0 days 8 404.0 g 12.37 35.0 body weighing method 0.0 85540 1604
Crl:CD(SD) body weight standard diet then acetaminophen (500 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 168.0 days 8 564.0 g 15.2 43.0 body weighing method 0.0 85550 1604
Crl:CD(SD) plasma acetaminophen level area under curve standard diet then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170.0 days 8 662.2 (ug/ml) x h 28.35 80.2 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 4-19 hr dosing 4-19 hr dosing 85586 1604
Crl:CD(SD) post-insult time to mammary tumor formation maternal milk (for 20 days) and bisphenol A (250 ug/kg) (for 15 days) then 7,12-dimethyltetraphene (30 mg/kg) (for 1 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. mammary gland integrity trait female  days-365.0 days 24 median 56.5 d manual palpation method 0.0 76269 1558
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 70.0 days 19 143.0 mg/dl 1.38 6.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85322 1604
Crl:CD(SD) food intake rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147.0 days 19 23.9 g/d 0.39 1.7 unspecified method 0.0 85296 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168.0 days 19 4.07 g/d/100g 0.05 0.2 unspecified method 0.0 85308 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 70.0 days 19 117.0 mg/dl 1.84 8.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85323 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 91.0 days 19 135.0 mg/dl 1.15 5.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85326 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 91.0 days 19 124.0 mg/dl 2.29 10.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85327 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 119.0 days 19 129.0 mg/dl 2.29 10.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85330 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 133.0 days 19 124.0 mg/dl 1.61 7.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85333 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 147.0 days 19 126.0 mg/dl 1.84 8.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85335 1604
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 147.0 days 19 0.47 mg/dl 0.05 0.21 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85350 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 91.0 days 19 1.0 mg/dl 0.08 0.35 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85343 1604
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 168.0 days 19 0.44 mg/dl 0.01 0.06 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85352 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 168.0 days 19 18.9 mg/dl 1.67 7.3 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85369 1604
Crl:CD(SD) plasma creatinine level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 70.0 days 19 0.41 mg/dl 0.0 0.02 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85370 1604
Crl:CD(SD) urine creatine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 134.0 days 19 2.44 umol/d 0.08 0.37 liquid chromatography-mass spectrometry 0.0 85382 1604
Crl:CD(SD) urine taurine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 134.0 days 19 141.5 umol/d 12.76 55.6 liquid chromatography-mass spectrometry 0.0 85398 1604
Crl:CD(SD) urine taurine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 169.0 days 19 129.3 umol/d 8.3 36.2 liquid chromatography-mass spectrometry 0.0 85400 1604
Crl:CD(SD) urine taurine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 169.0 days 19 153.1 umol/d 7.75 33.8 liquid chromatography-mass spectrometry 0.0 85401 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 119.0 days 19 56.4 U/l 2.13 9.3 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85418 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 119.0 days 19 36.8 U/l 1.19 5.2 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85435 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (300 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147.0 days 8 24.3 g/d 0.32 0.9 unspecified method 0.0 85477 1604
Crl:CD(SD) plasma acetaminophen level standard diet then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170.0 days 8 118.1 ug/ml 6.43 18.2 high-performance liquid chromatography 0.0 acetaminophen dosing 240 min 4 hr after dosing 85579 1604
Crl:CD(SD) plasma acetaminophen level area under curve standard diet then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170.0 days 8 893.3 (ug/ml) x h 44.55 126.0 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 4-19 hr dosing 4-19 hr dosing 85587 1604
Crl:CD(SD) liver wet weight standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver mass male 170.0 days 8 12.2 g 0.77 2.17 unspecified method 0.0 85558 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 119.0 days 19 127.0 mg/dl 1.84 8.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85331 1604
Crl:CD(SD) serum progesterone level maternal milk (for 20 days) and vehicle control condition (for 15 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. blood progesterone amount female 50.0 days 32 12.5 ng/ml 2.8 15.84 radioimmunoassay 0.0 76262 1558
Crl:CD(SD) mammary tumor number maternal milk (for 20 days) and bisphenol A (25 ug/kg) (for 15 days) then 7,12-dimethyltetraphene (30 mg/kg) (for 1 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. mammary gland integrity trait female  days-365.0 days 34 3.82 null 0.43 2.51 manual palpation method 0.0 76265 1558
Crl:CD(SD) liver reduced glutathione level to liver weight ratio standard diet then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170.0 days 8 9.07 umol/g 0.25 0.72 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 enzyme recycling method reduced liver glutathione level to liver weight ratio 85568 1604
Crl:CD(SD) liver reduced glutathione level to liver weight ratio standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170.0 days 8 6.24 umol/g 0.31 0.87 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 enzyme recycling method 85570 1604
Crl:CD(SD) body weight standard diet then acetaminophen (300 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 84.0 days 8 418.0 g 6.72 19.0 body weighing method 0.0 85525 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126.0 days 8 18.7 g/d 1.45 4.1 unspecified method 0.0 85475 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 147.0 days 8 431.0 g 8.49 24.0 body weighing method 0.0 85547 1604
Crl:CD(SD) liver oxidized glutathione level to liver weight ratio standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170.0 days 8 0.16 umol/g 0.01 0.03 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 enzyme recycling method 85576 1604
Crl:CD(SD) plasma angiotensin II level control condition Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. blood angiotensin II amount male 28.0 days 5 125.4 pg/ml 14.8 33.09 automated plasma analysis 0.0 100762 2521
Crl:CD(SD) urine protein level to urine creatinine level ratio control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. total urine protein amount male 112.0 days 5 1.98 null 0.31 0.69 urine protein analysis 0.0 100770 2521
Crl:CD(SD) plasma very low density lipoprotein cholesterol level control condition (for 140 days) Wang HY, et al., Biol Open. 2016 Jul 15;5(7):979-86. doi: 10.1242/bio.019802. blood VLDL cholesterol amount not specified 140.0 days 5 5.41 mg/dl 2.59 5.78 plasma very low-density lipoprotein-cholesterol measurement test 0.0 105039 3009
Crl:CD(SD) plasma low density lipoprotein cholesterol level control condition (for 140 days) Wang HY, et al., Biol Open. 2016 Jul 15;5(7):979-86. doi: 10.1242/bio.019802. blood LDL cholesterol amount not specified 140.0 days 5 10.54 mg/dl 2.01 4.49 plasma low-density lipoprotein-cholesterol measurement test 0.0 105041 3009
Crl:CD(SD) retinal outer layer thickness AMG-8718 (600 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 132.1 um 3.18 7.1 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105477 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 126.1 um 4.11 9.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105495 3016
Crl:CD(SD) plasma AMG-8718 level area under curve (AUC) AMG-8718 (10 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 15900.0 ng/ml/h 1507.11 3370.0 liquid chromatography-mass spectrometry 0.0 samples at 0.5, 1.5, 5, 10, 24 hours auc 105425 3016
Crl:CD(SD) plasma AMG-8718 level area under curve (AUC) AMG-8718 (10 mg/kg) (for 24 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 81.0 days-88.0 days 5 21800.0 ng/ml/h 2710.11 6060.0 liquid chromatography-mass spectrometry 0.0 samples at 0.5, 1.5, 5, 10, 24 hours auc 105431 3016
Crl:CD(SD) plasma AMG-8718 level area under curve (AUC) AMG-8718 (100 mg/kg) (for 24 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 81.0 days-88.0 days 5 217000.0 ng/ml/h 10107.03 22600.0 liquid chromatography-mass spectrometry 0.0 samples at 0.5, 1.5, 5, 10, 24 hours auc 105432 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (100 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 134.5 um 3.35 7.5 optical coherence tomography 0.0 optical coherence tomography outer retinal layer 105468 3016
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 136.0 um 3.49 7.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105482 3016
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 132.2 um 3.71 8.3 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105490 3016
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 129.8 um 4.02 9.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105498 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 120.7 um 4.2 9.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105496 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 11.3 null 0.32 0.72 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105451 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 40.9 um 2.15 4.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105457 3016
Crl:CD(SD) full retina thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 137.0 days-144.0 days 5 191.6 um 7.56 16.9 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105458 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (10 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 125.1 um 3.98 8.9 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105487 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (100 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 124.7 um 3.89 8.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105488 3016
Crl:CD(SD) absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 5 8.08 mmHg 6.37 14.25 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15511 381
Crl:CD(SD) tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.54 ml 0.03 0.1 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15526 381
Crl:CD(SD) body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 7 37.6 degrees C 0.2 0.54 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15574 381
Crl:CD(SD) absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 5 -0.03 null 0.01 0.03 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15601 381
Crl:CD(SD) partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 26.52 mmHg 0.37 0.98 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15628 381
Crl:CD(SD) partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 6 33.77 mmHg 1.44 3.53 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15362 381
Crl:CD(SD) creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 6 2.0 ml/min 0.19 0.48 urine creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51683 481
Crl:CD(SD) mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 5 101.2 mmHg 3.26 7.28 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51733 481
Crl:CD(SD) plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 6 0.31 mg/dl 0.03 0.06 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51895 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 29.83 mmHg 4.13 8.26 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51912 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 -61.73 beats/min 11.0 24.59 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51988 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -19.59 beats/min 24.09 63.74 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 52070 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 11.58 mmHg 5.14 10.28 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50544 481
Crl:CD(SD) heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 5 425.43 beats/min 14.64 32.74 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50578 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 -0.2 mmHg 2.08 4.16 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50816 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -48.95 beats/min 23.61 47.22 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50865 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 17.13 beats/min 16.45 32.89 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50893 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -18.72 beats/min 14.13 28.25 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50954 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 4.02 mmHg 4.61 10.32 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50996 481
Crl:CD(SD) mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 107.21 mmHg 2.57 6.79 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51078 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 23.55 mmHg 4.9 10.95 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51167 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 25.24 mmHg 4.55 12.05 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51169 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 22.76 beats/min 22.93 60.67 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51332 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 10.13 mmHg 4.49 10.03 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51415 481
Crl:CD(SD) urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 9 13.41 mEq/d 1.64 4.91 flame atomic emission spectrometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51639 481
Crl:CD(SD) urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 9 0.59 mg/d 0.08 0.25 automated urine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51669 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 1.04 mmHg 1.62 3.61 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50451 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 7.33 mmHg 1.67 4.42 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50453 481
Crl:CD(SD) body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 37.76 degrees C 0.27 0.89 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14177 381
Crl:CD(SD) respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 118.53 breaths/min 6.37 22.98 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17324 381
Crl:CD(SD) absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 99.99 beats/min 6.52 17.26 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14114 381
Crl:CD(SD) minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 45.22 ml/min 3.8 12.61 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19720 381
Crl:CD(SD) absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 5 -4.05 mmHg 0.58 1.3 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20982 381
Crl:CD(SD) body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 38.01 degrees C 0.18 0.61 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19945 381
Crl:CD(SD) mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 125.48 mmHg 5.8 14.2 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20132 381
Crl:CD(SD) partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 30.46 mmHg 0.82 2.18 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19687 381
Crl:CD(SD) heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 8 336.8 beats/min 15.61 44.15 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18083 381
Crl:CD(SD) partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 5 51.86 mmHg 0.35 0.77 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17008 381
Crl:CD(SD) mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 110.96 mmHg 3.9 11.04 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18765 381
Crl:CD(SD) mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 99.83 mmHg 1.4 3.71 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18778 381
Crl:CD(SD) minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 43.51 ml/min 3.51 11.65 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18966 381
Crl:CD(SD) blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 5 7.48 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 18987 381
Crl:CD(SD) mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 9 63.78 fl 0.56 1.67 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36287 401
Crl:CD(SD) serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 9 166.67 mg/dl 7.66 22.99 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36321 401
Crl:CD(SD) mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 9 20.86 pg 0.19 0.56 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36356 401
Crl:CD(SD) serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 9 5.76 g/dl 0.11 0.34 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37414 401
Crl:CD(SD) serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 9 6.63 g/dl 0.12 0.37 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37416 401
Crl:CD(SD) blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 7.44 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19321 381
Crl:CD(SD) respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 119.16 breaths/min 3.75 13.5 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18157 381
Crl:CD(SD) respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 152.33 breaths/min 6.32 22.79 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18208 381
Crl:CD(SD) percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 96.68 % 10.15 32.1 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49264 461
Crl:CD(SD) heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 4.4 g/kg 0.2 0.63 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49667 461
Crl:CD(SD) heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 257.17 beats/min 13.09 41.4 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49972 461
Crl:CD(SD) heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 250.69 beats/min 6.17 19.5 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49974 461
Crl:CD(SD) serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 9 6.87 mg/dl 0.14 0.42 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38838 401
Crl:CD(SD) plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 9 18.33 mmol/l 0.44 1.32 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42358 401
Crl:CD(SD) plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 9 18.56 mmol/l 0.77 2.3 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42360 401
Crl:CD(SD) blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 9 1.07 x 1000 cells/ul 0.16 0.47 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42368 401
Crl:CD(SD) blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 9 1.32 x 1000 cells/ul 0.21 0.63 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42370 401
Crl:CD(SD) blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 9 14.53 g/dl 0.19 0.57 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42741 401
Crl:CD(SD) percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 131.32 % 6.81 24.57 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54526 381
Crl:CD(SD) percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 128.24 % 4.58 16.5 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53602 381
Crl:CD(SD) plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 9 0.29 mg/dl 0.02 0.06 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40799 401
Crl:CD(SD) serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 9 102.67 mmol/l 0.62 1.87 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41107 401
Crl:CD(SD) serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 9 105.56 mmol/l 0.71 2.13 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38184 401
Crl:CD(SD) serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 9 55.44 U/l 2.84 8.52 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41600 401
Crl:CD(SD) serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 9 96.0 U/l 7.4 22.2 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41614 401
Crl:CD(SD) blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 9 0.05 x 1000 cells/ul 0.02 0.07 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38346 401
Crl:CD(SD) percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 27.46 % 7.86 24.85 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47522 461
Crl:CD(SD) methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 6.3 ml/min/kg 0.19 0.55 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57453 526
Crl:CD(SD) lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 15 1.36 g/kg 0.04 0.17 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57577 526
Crl:CD(SD) heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 7 389.59 beats/min 19.9 52.64 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16124 381
Crl:CD(SD) heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 417.18 beats/min 29.61 88.83 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16126 381
Crl:CD(SD) heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 426.74 beats/min 7.88 20.86 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16432 381
Crl:CD(SD) absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 5 0.04 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16667 381
Crl:CD(SD) logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 -6.83 null 0.1 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54747 522
Crl:CD(SD) methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 6.28 ml/min/kg 0.36 1.01 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58836 526
Crl:CD(SD) methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 8.59 ml/min/kg 0.74 2.34 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58838 526
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 42.78 % 4.97 14.92 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55001 522
Crl:CD(SD) concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 0.1 10E-7mol/l 0.03 0.11 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56454 522
Crl:CD(SD) methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 7.65 ml/min/kg 0.45 1.43 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59864 526
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 60.75 % 5.67 16.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56705 522
Crl:CD(SD) logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 -7.48 null 0.12 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56738 522
Crl:CD(SD) logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 19 -6.87 null 0.07 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56774 522
Crl:CD(SD) sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 98.22 % 0.64 1.92 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56855 522
Crl:CD(SD) arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 9 7.77 ml/min/g 0.98 2.93 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45893 461
Crl:CD(SD) arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 12.7 ml/min/g 3.58 11.33 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46178 461
Crl:CD(SD) left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 114.13 mmHg 6.85 18.12 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45018 461
Crl:CD(SD) heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 1.03 g 0.04 0.12 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45032 461
Crl:CD(SD) percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 40.0 % 4.91 12.98 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45042 461
Crl:CD(SD) percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 58.88 % 11.71 30.98 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45044 461
Crl:CD(SD) arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 9 14.61 ml/min/g 0.64 1.91 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45085 461
Crl:CD(SD) time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 1139.17 s 46.23 146.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45105 461
Crl:CD(SD) left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 75.38 mmHg 5.16 13.65 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47395 461
Crl:CD(SD) left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 48.23 mmHg 6.22 18.66 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47405 461
Crl:CD(SD) heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 251.21 beats/min 6.4 19.2 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45354 461
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 147.0 days 19 16.1 U/l 0.69 3.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85454 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84.0 days 8 6.04 g/d/100g 0.23 0.66 unspecified method 0.0 on days 11-14 85493 1604
Crl:CD(SD) body weight standard diet then acetaminophen (500 mg/kg) (for 1 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 71.0 days 8 375.0 g 6.36 18.0 body weighing method 0.0 85520 1604
Crl:CD(SD) body weight standard diet then acetaminophen (500 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 105.0 days 8 472.0 g 8.49 24.0 body weighing method 0.0 85532 1604
Crl:CD(SD) liver wet weight standard diet then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver mass male 170.0 days 8 20.3 g 0.7 1.98 unspecified method 0.0 liver weight not available 85556 1604
Crl:CD(SD) body weight standard diet then acetaminophen (500 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 147.0 days 8 549.0 g 12.73 36.0 body weighing method 0.0 85544 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105.0 days 19 5.28 g/d/100g 0.06 0.24 unspecified method 0.0 85302 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84.0 days 19 5.78 g/d/100g 0.1 0.42 unspecified method 0.0 85300 1604
Crl:CD(SD) body weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 105.0 days 19 481.0 g 11.7 51.0 body weighing method 0.0 85314 1604
Crl:CD(SD) body weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 147.0 days 19 563.0 g 13.54 59.0 body weighing method 0.0 85318 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 126.0 days 19 401.0 g 4.82 21.0 body weighing method 0.0 85317 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 147.0 days 19 129.0 mg/dl 0.92 4.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85334 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 105.0 days 19 15.0 mg/dl 0.48 2.1 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85360 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 91.0 days 19 18.8 mg/dl 0.53 2.3 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85358 1604
Crl:CD(SD) urine creatinine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 106.0 days 19 11.98 mg/d 0.42 1.84 liquid chromatography-mass spectrometry 0.0 85389 1604
Crl:CD(SD) urine taurine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 70.0 days 19 68.7 umol/d 8.69 37.9 liquid chromatography-mass spectrometry 0.0 85394 1604
Crl:CD(SD) liver oxidized glutathione level to liver weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170.0 days 19 0.21 umol/g 0.01 0.03 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 enzyme recycling method oxidized liver glutathione level to liver weight ratio 85408 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 70.0 days 19 60.7 U/l 1.19 5.2 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85410 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 78.0 days 19 61.0 U/l 2.09 9.1 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85412 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 78.0 days 19 59.1 U/l 1.28 5.6 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85413 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 133.0 days 19 57.1 U/l 2.18 9.5 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85420 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 78.0 days 19 13.7 U/l 0.48 2.1 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85444 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 91.0 days 19 14.4 U/l 1.19 5.2 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85446 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147.0 days 8 17.7 g/d 1.31 3.7 unspecified method 0.0 85481 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (500 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168.0 days 8 22.8 g/d 0.71 2.0 unspecified method 0.0 85484 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (300 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168.0 days 8 23.4 g/d 0.42 1.2 unspecified method 0.0 85483 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (300 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84.0 days 8 5.74 g/d/100g 0.1 0.29 unspecified method 0.0 on days 11-14 85489 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (500 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105.0 days 8 5.12 g/d/100g 0.15 0.42 unspecified method 0.0 on days 32-35 85496 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (500 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126.0 days 8 4.53 g/d/100g 0.13 0.36 unspecified method 0.0 on days 53-56 85502 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (300 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147.0 days 8 4.09 g/d/100g 0.45 1.28 unspecified method 0.0 on days 74-77 85507 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 105.0 days 8 365.0 g 6.36 18.0 body weighing method 0.0 85535 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 168.0 days 8 440.0 g 9.19 26.0 body weighing method 0.0 85553 1604
Crl:CD(SD) plasma acetaminophen level standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170.0 days 8 2.4 ug/ml 0.71 2.0 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 19 hr after dosing 85585 1604
Crl:CD(SD) serum estradiol level maternal milk (for 20 days) and vehicle control condition (for 15 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. blood estradiol amount female 50.0 days 32 34.4 pg/ml 2.7 15.27 radioimmunoassay 0.0 76260 1558
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 133.0 days 19 0.55 mg/dl 0.03 0.12 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85348 1604
Crl:CD(SD) food intake rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84.0 days 19 24.7 g/d 0.48 2.1 unspecified method 0.0 85290 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 71.0 days 19 288.0 g 3.67 16.0 body weighing method 0.0 85311 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 105.0 days 19 121.0 mg/dl 1.61 7.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85329 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 105.0 days 19 0.81 mg/dl 0.06 0.27 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85345 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 168.0 days 19 0.56 mg/dl 0.03 0.15 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85353 1604
Crl:CD(SD) urine taurine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 134.0 days 19 171.1 umol/d 13.08 57.0 liquid chromatography-mass spectrometry 0.0 85399 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 91.0 days 19 56.3 U/l 1.12 4.9 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85414 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 119.0 days 19 58.8 U/l 1.54 6.7 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85419 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 78.0 days 19 33.9 U/l 0.83 3.6 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85428 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 70.0 days 19 14.3 U/l 0.55 2.4 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85442 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 147.0 days 19 34.4 U/l 1.31 5.7 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85439 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 168.0 days 19 12.8 U/l 0.69 3.0 automated blood analysis 0.0 TBA-120FR, Toshiba corporation, Japan 85457 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105.0 days 8 16.7 g/d 0.95 2.7 unspecified method 0.0 85469 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84.0 days 8 6.04 g/d/100g 0.21 0.58 unspecified method 0.0 on days 11-14 85492 1604
Crl:CD(SD) plasma acetaminophen level standard diet then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170.0 days 8 1.1 ug/ml 0.32 0.9 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 19 hr after dosing 85583 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (500 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126.0 days 8 24.9 g/d 0.85 2.4 unspecified method 0.0 85472 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126.0 days 8 22.1 g/d 0.71 2.0 unspecified method 0.0 85474 1604
Crl:CD(SD) body weight standard diet then acetaminophen (300 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 105.0 days 8 477.0 g 7.42 21.0 body weighing method 0.0 85531 1604
Crl:CD(SD) retinal outer layer thickness AMG-8718 (10 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 138.8 um 3.67 8.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105475 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 120.9 um 5.19 11.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105497 3016
Crl:CD(SD) plasma AMG-8718 level area under curve (AUC) AMG-8718 (100 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 221000.0 ng/ml/h 15831.36 35400.0 liquid chromatography-mass spectrometry 0.0 samples at 0.5, 1.5, 5, 10, 24 hours auc 105426 3016
Crl:CD(SD) plasma AMG-8718 maximum concentration AMG-8718 (600 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 50300.0 ng/ml 5321.84 11900.0 liquid chromatography-mass spectrometry 0.0 max conc 105430 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (100 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 59.0 days-66.0 days 5 38.5 um 1.07 2.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105436 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 49.2 um 2.95 6.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105456 3016
Crl:CD(SD) full retina thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 81.0 days-88.0 days 5 185.4 um 5.41 12.1 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105448 3016
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 142.2 um 2.68 6.0 optical coherence tomography 0.0 optical coherence tomography outer retinal layer 105466 3016
Crl:CD(SD) plasma AMG-8718 maximum concentration AMG-8718 (10 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 81.0 days-88.0 days 5 4450.0 ng/ml 496.41 1110.0 liquid chromatography-mass spectrometry 0.0 max conc 105428 3016
Crl:CD(SD) full retina thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 137.0 days-144.0 days 5 184.4 um 8.09 18.1 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105460 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 134.2 um 4.79 10.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105491 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (10 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 140.0 um 3.22 7.2 optical coherence tomography 0.0 optical coherence tomography outer retinal layer 105467 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 125.7 um 3.89 8.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105503 3016
Crl:CD(SD) retinal outer nuclear layer thickness vehicle control condition (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 50.6 um 1.61 3.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105454 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (10 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 127.2 um 3.85 8.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105479 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 112.7 um 2.91 6.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105501 3016