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CLINICAL MEASUREMENT - ANNOTATIONS

The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. For more information about these vocabularies please see Shimoyama et al. Three ontologies to define phenotype measurement data. Front Genet. 2012;3:87. Epub 2012 May 28 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
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Accession:CMO:0000727 term browser browse the term
Definition:A calculated value for logarithm of the concentration of sodium nitroprusside (SNP), the red-coloured inorganic salt with the formula Na2[Fe(CN)5NO]-2H2O used as a potent vasodilator, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of SNP is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during SNP-induced relaxation of the vessel wall (i.e. the maximum effect of SNP which is the minimum contractile energy).
Synonyms:exact_synonym: sodium nitroprusside Log half maximal effective concentration (Log EC50)
 xref: CHEBI:29321;   CHEBI:9179


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Related Phenotype Data for Term "logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)" (CMO:0000727)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
Term paths to the root
Path 1
Term Annotations click to browse term
  clinical measurement 2369
    chemical response/sensitivity measurement 0
      sodium nitroprusside response/sensitivity measurement 0
        concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) 0
          logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 0
Path 2
Term Annotations click to browse term
  clinical measurement 2369
    cardiovascular measurement 610
      blood vessel measurement 44
        blood vessel dilation measurement 0
          blood vessel dilation force reduction measurement 0
            calculated blood vessel dilation force reduction measurement 0
              concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) 0
                logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 0
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