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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:desipramine pharmacodynamics pathway
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Accession:PW:0002090 term browser browse the term
Definition:The pathway of desipramine-target interaction and of the biochemical or physiological responses to drug. The drug is used in the treatment of major depression and its effect results from inhibition of norepinephrine and to a lesser extent serotonin neurotransmitter reuptake. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00423

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desipramine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A ISO SMPDB SMP:00423 NCBI chrNW_004955403:49,394,173...49,485,881
Ensembl chrNW_004955403:49,399,127...49,485,934 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00423 NCBI chrNW_004955435:19,537,224...19,563,631
Ensembl chrNW_004955435:19,536,634...19,564,580 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 ISO SMPDB SMP:00423 NCBI chrNW_004955468:11,898,786...11,924,341
Ensembl chrNW_004955468:11,898,915...11,922,400 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00423 NCBI chrNW_004955555:869,508...892,510
Ensembl chrNW_004955555:869,325...893,542 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00423 NCBI chrNW_004955462:8,072,519...8,095,311
Ensembl chrNW_004955462:8,073,679...8,094,880 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00423 NCBI chrNW_004955467:9,261,775...9,268,743
Ensembl chrNW_004955467:9,261,775...9,268,743 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00423 NCBI chrNW_004955508:3,848,745...3,875,992
Ensembl chrNW_004955508:3,859,399...3,875,276 		JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00423 NCBI chrNW_004955572:1,507,290...1,524,359
Ensembl chrNW_004955572:1,507,290...1,524,422 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO SMPDB SMP:00423 NCBI chrNW_004955415:32,182,536...32,457,511
Ensembl chrNW_004955415:32,183,442...32,400,595 		JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00423 NCBI chrNW_004955532:2,163,529...2,283,509
Ensembl chrNW_004955532:2,163,529...2,283,508 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00423 NCBI chrNW_004955451:14,041,848...14,059,740
Ensembl chrNW_004955451:14,038,668...14,059,848 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit ISO SMPDB SMP:00423 NCBI chrNW_004955528:825,314...840,994
Ensembl chrNW_004955528:825,308...841,270 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO SMPDB SMP:00423 NCBI chrNW_004955545:1,065,457...1,077,056
Ensembl chrNW_004955545:1,065,457...1,077,526 		JBrowse link
G Drd1 dopamine receptor D1 ISO SMPDB SMP:00423 NCBI chrNW_004955408:28,003,229...28,006,595
Ensembl chrNW_004955408:28,003,229...28,006,595 		JBrowse link
G Fxyd2 FXYD domain containing ion transport regulator 2 ISO SMPDB SMP:00423 NCBI chrNW_004955412:19,039,635...19,046,172
Ensembl chrNW_004955412:19,039,635...19,046,159 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO SMPDB SMP:00423 NCBI chrNW_004955513:5,154,864...5,178,636
Ensembl chrNW_004955513:5,154,864...5,178,636 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO SMPDB SMP:00423 NCBI chrNW_004955442:8,171,114...8,565,187
Ensembl chrNW_004955442:8,174,232...8,562,059 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A ISO SMPDB SMP:00423 NCBI chrNW_004955419:24,105,360...24,272,533
Ensembl chrNW_004955419:24,104,820...24,273,113 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO SMPDB SMP:00423 NCBI chrNW_004955446:4,913,181...4,917,726
Ensembl chrNW_004955446:4,913,884...4,915,146 		JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 ISO SMPDB SMP:00423 NCBI chrNW_004955479:2,062,607...2,545,576
Ensembl chrNW_004955479:2,062,608...2,543,125 		JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00423 NCBI chrNW_004955485:8,468,117...8,472,220
Ensembl chrNW_004955485:8,467,207...8,470,950 		JBrowse link
G Oprm1 opioid receptor mu 1 ISO SMPDB SMP:00423 NCBI chrNW_004955439:7,870,563...7,923,817
Ensembl chrNW_004955439:7,757,569...7,923,817 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO SMPDB SMP:00423 NCBI chrNW_004955415:26,266,513...26,496,905
Ensembl chrNW_004955415:26,266,484...26,497,001 		JBrowse link
G Pomc proopiomelanocortin ISO SMPDB SMP:00423 NCBI chrNW_004955469:7,217,233...7,220,401
Ensembl chrNW_004955469:7,217,363...7,220,386 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 ISO SMPDB SMP:00423 NCBI chrNW_004955427:25,157,179...25,244,020
Ensembl chrNW_004955427:25,157,179...25,243,473 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 ISO SMPDB SMP:00423 NCBI chrNW_004955468:4,375,517...4,383,383
Ensembl chrNW_004955468:4,375,157...4,383,502 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 ISO SMPDB SMP:00423 NCBI chrNW_004955433:13,170,986...13,216,270
Ensembl chrNW_004955433:13,170,699...13,216,330 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO SMPDB SMP:00423 NCBI chrNW_004955504:721,470...747,553
Ensembl chrNW_004955504:721,429...747,630 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO SMPDB SMP:00423 NCBI chrNW_004955481:3,088,440...3,122,421
Ensembl chrNW_004955481:3,088,416...3,125,711 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3930
    drug pathway 348
      nervous system drug pathway 151
        antidepressant drug pathway 34
          non-selective monoamine reuptake inhibitor drug pathway 30
            desipramine drug pathway 29
              desipramine pharmacodynamics pathway 29
paths to the root