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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:erythropoietin signaling pathway
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Accession:PW:0000987 term browser browse the term
Definition:Erythropoietin (EPO) signaling is crucial for the production of blood cell or erythropoiesis and also plays important roles in wound healing and responses to neural injury. EPO is a glycoprotein hormone and also a cytokine whose receptor belongs to type I cytokine receptor. The pathway engages the Jak-Stat intracellular cascade.
Synonyms:exact_synonym: EPO signaling pathway
 related_synonym: PID:200183

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erythropoietin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2 apoptosis regulator ISO PID PID:200183 NCBI chrNW_004624792:8,854,345...9,032,727
Ensembl chrNW_004624792:8,859,522...9,031,344 		JBrowse link
G Bcl2l1 BCL2 like 1 ISO PID PID:200183 NCBI chrNW_004624741:788,445...838,513
Ensembl chrNW_004624741:789,355...839,507 		JBrowse link
G Btk Bruton tyrosine kinase ISO PID PID:200183 NCBI chrNW_004624902:1,173,101...1,216,662
Ensembl chrNW_004624902:1,182,682...1,216,171 		JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200183 NCBI chrNW_004624784:14,577,582...14,671,816
Ensembl chrNW_004624784:14,577,515...14,667,575 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein ISO PID PID:200183 NCBI chrNW_004624945:734,532...767,184
Ensembl chrNW_004624945:734,532...767,168 		JBrowse link
G Epor erythropoietin receptor ISO PID PID:200183 NCBI chrNW_004624828:3,181,772...3,187,242
Ensembl chrNW_004624828:3,181,957...3,187,231 		JBrowse link
G Gab1 GRB2 associated binding protein 1 ISO PID PID:200183 NCBI chrNW_004624853:2,639,882...2,763,195
Ensembl chrNW_004624853:2,639,891...2,765,144 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200183 NCBI chrNW_004624801:5,143,239...5,219,136
Ensembl chrNW_004624801:5,143,141...5,219,244 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO PID PID:200183 NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D ISO PID PID:200183 NCBI chrNW_004624843:5,685,409...5,774,459
Ensembl chrNW_004624843:5,685,502...5,773,469 		JBrowse link
G Irs2 insulin receptor substrate 2 ISO PID PID:200183 NCBI chrNW_004624793:2,615,092...2,636,835
Ensembl chrNW_004624793:2,614,589...2,636,947 		JBrowse link
G Jak2 Janus kinase 2 ISO PID PID:200183 NCBI chrNW_004624736:9,724,876...9,827,364
Ensembl chrNW_004624736:9,724,369...9,830,365 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISO PID PID:200183 NCBI chrNW_004624886:4,029,318...4,168,797
Ensembl chrNW_004624886:4,027,178...4,168,902 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 ISO PID PID:200183 NCBI chrNW_004624754:21,528,121...21,598,064
Ensembl chrNW_004624754:21,527,333...21,597,733 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200183 NCBI chrNW_004624928:1,442,216...1,494,275
Ensembl chrNW_004624928:1,439,146...1,494,266 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO PID PID:200183 NCBI chrNW_004624830:5,334,273...5,430,887
Ensembl chrNW_004624830:5,333,616...5,408,723 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200183 NCBI chrNW_004624815:1,290,106...1,376,961
Ensembl chrNW_004624815:1,289,997...1,369,610 		JBrowse link
G Plcg1 phospholipase C gamma 1 ISO PID PID:200183 NCBI chrNW_004624919:1,766,533...1,800,130
Ensembl chrNW_004624919:1,766,149...1,803,097 		JBrowse link
G Plcg2 phospholipase C gamma 2 ISO PID PID:200183 NCBI chrNW_004624746:5,678,057...5,824,663
Ensembl chrNW_004624746:5,682,666...5,821,855 		JBrowse link
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 ISO PID PID:200183 NCBI chrNW_004624747:19,721,581...19,813,639
Ensembl chrNW_004624747:19,721,468...19,813,670 		JBrowse link
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 ISO PID PID:200183 NCBI chrNW_004624860:3,580,225...3,595,403
Ensembl chrNW_004624860:3,580,560...3,595,090 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO PID PID:200183 NCBI chrNW_004624772:7,340,152...7,425,218
Ensembl chrNW_004624772:7,368,653...7,424,938 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO PID PID:200183 NCBI chrNW_004624760:4,376,733...4,474,834
Ensembl chrNW_004624760:4,376,713...4,474,837 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 ISO PID PID:200183 NCBI chrNW_004624747:20,729,142...20,759,631
Ensembl chrNW_004624747:20,730,751...20,759,625 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO PID PID:200183 NCBI chrNW_004624885:2,511,039...2,520,883
Ensembl chrNW_004624885:2,511,240...2,521,155 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO PID PID:200183 NCBI chrNW_004624801:7,841,230...7,843,912
Ensembl chrNW_004624801:7,840,889...7,843,860 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200183 NCBI chrNW_004624738:20,466,120...20,591,966
Ensembl chrNW_004624738:20,466,117...20,591,910 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID PID:200183 NCBI chrNW_004624854:5,067,578...5,106,052
Ensembl chrNW_004624854:5,067,535...5,102,106 		JBrowse link
G Tec tec protein tyrosine kinase ISO PID PID:200183 NCBI chrNW_004624761:18,695,168...18,824,045
Ensembl chrNW_004624761:18,695,177...18,822,078 		JBrowse link
G Trpc6 transient receptor potential cation channel subfamily C member 6 ISO PID PID:200183 NCBI chrNW_004624878:1,321,022...1,469,964
Ensembl chrNW_004624878:1,321,497...1,468,865 		JBrowse link
G Vav2 vav guanine nucleotide exchange factor 2 ISO PID PID:200183 NCBI chrNW_004624760:2,081,796...2,201,520
Ensembl chrNW_004624760:2,081,796...2,201,934 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3917
    signaling pathway 1875
      hormone signaling pathway 368
        peptide and protein hormone signaling pathway 265
          erythropoietin signaling pathway 31
paths to the root