Vav2 (vav guanine nucleotide exchange factor 2) - Rat Genome Database

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Gene: Vav2 (vav guanine nucleotide exchange factor 2) Heterocephalus glaber
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Symbol: Vav2
Name: vav guanine nucleotide exchange factor 2
RGD ID: 18918108
Description: ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); phosphotyrosine residue binding (ortholog); INVOLVED IN cell migration (ortholog); cell projection assembly (ortholog); lamellipodium assembly (ortholog); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; erythropoietin signaling pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); Ehlers-Danlos syndrome classic type 1 (ortholog); Kleefstra syndrome 1 (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: guanine nucleotide exchange factor VAV2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247602,081,796 - 2,201,934 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247602,081,796 - 2,201,520 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Vav2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247602,081,796 - 2,201,934 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247602,081,796 - 2,201,520 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
VAV2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,761,894 - 133,992,324 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,761,894 - 133,992,604 (-)EnsemblGRCh38hg38GRCh38
GRCh379136,627,016 - 136,857,446 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,616,837 - 135,847,226 (-)NCBINCBI36Build 36hg18NCBI36
Build 349133,656,570 - 133,886,959NCBI
Celera9107,174,789 - 107,404,640 (-)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9106,127,910 - 106,303,677 (-)NCBIHuRef
CHM1_19136,775,446 - 137,005,937 (-)NCBICHM1_1
T2T-CHM13v2.09145,977,670 - 146,207,128 (-)NCBIT2T-CHM13v2.0
Vav2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,152,116 - 27,317,620 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl227,152,116 - 27,317,045 (-)EnsemblGRCm39 Ensembl
GRCm38227,262,104 - 27,427,608 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,262,104 - 27,427,033 (-)EnsemblGRCm38mm10GRCm38
MGSCv37227,119,155 - 27,282,345 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36227,085,644 - 27,248,836 (-)NCBIMGSCv36mm8
Celera226,966,692 - 27,129,427 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.36NCBI
Vav2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,982,754 - 31,152,116 (-)NCBIGRCr8
mRatBN7.2310,584,688 - 10,754,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,584,688 - 10,754,052 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,651,677 - 13,821,126 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,237,080 - 22,406,540 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,492,356 - 20,661,812 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,811,504 - 5,976,311 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,811,504 - 5,976,244 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,173,752 - 11,337,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,153,681 - 6,347,676 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.136,155,986 - 6,347,501 (-)NCBI
Celera35,380,148 - 5,548,591 (-)NCBICelera
Cytogenetic Map3p12NCBI
Vav2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,985,246 - 3,121,324 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,985,246 - 3,121,324 (-)NCBIChiLan1.0ChiLan1.0
VAV2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,361,720 - 5,593,549 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,364,289 - 5,595,883 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,883,197 - 105,115,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,492,314 - 133,690,708 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,494,481 - 133,668,036 (-)Ensemblpanpan1.1panPan2
VAV2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1950,103,004 - 50,232,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl950,094,447 - 50,230,954 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,384,008 - 49,543,991 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,977,087 - 51,137,042 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,977,257 - 51,137,583 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,738,436 - 49,898,214 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0950,081,036 - 50,241,047 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0950,158,900 - 50,319,194 (-)NCBIUU_Cfam_GSD_1.0
Vav2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947200,140,891 - 200,272,429 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,112,499 - 3,232,212 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366693,062,538 - 3,234,167 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAV2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,303,144 - 273,476,207 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,303,142 - 273,476,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,276,069 - 307,449,195 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VAV2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,142,966 - 4,377,849 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,143,139 - 4,377,852 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666058616,999 - 702,000 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000023945   ⟹   ENSHGLP00000023727
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247602,081,796 - 2,201,516 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000023946   ⟹   ENSHGLP00000023728
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247602,083,625 - 2,201,934 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000023947   ⟹   ENSHGLP00000023729
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247602,083,625 - 2,201,449 (-)Ensembl
RefSeq Acc Id: XM_004848993   ⟹   XP_004849050
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247602,081,796 - 2,201,519 (-)NCBI
RefSeq Acc Id: XM_004848994   ⟹   XP_004849051
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247602,081,796 - 2,201,517 (-)NCBI
RefSeq Acc Id: XM_004848995   ⟹   XP_004849052
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247602,081,796 - 2,201,516 (-)NCBI
RefSeq Acc Id: XM_021261772   ⟹   XP_021117431
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247602,081,796 - 2,201,520 (-)NCBI
RefSeq Acc Id: XM_021261773   ⟹   XP_021117432
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247602,081,796 - 2,201,518 (-)NCBI
RefSeq Acc Id: XM_021261774   ⟹   XP_021117433
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247602,081,796 - 2,201,519 (-)NCBI
RefSeq Acc Id: XM_021261775   ⟹   XP_021117434
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247602,081,796 - 2,201,518 (-)NCBI
RefSeq Acc Id: XM_021261776   ⟹   XP_021117435
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247602,081,796 - 2,201,519 (-)NCBI
RefSeq Acc Id: XR_002396498
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247602,081,796 - 2,201,520 (-)NCBI
RefSeq Acc Id: XP_021117431   ⟸   XM_021261772
- Peptide Label: isoform X1
- UniProtKB: G5B8I3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021117433   ⟸   XM_021261774
- Peptide Label: isoform X3
- UniProtKB: G5B8I3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004849050   ⟸   XM_004848993
- Peptide Label: isoform X6
- UniProtKB: G5B8I3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021117435   ⟸   XM_021261776
- Peptide Label: isoform X5
- UniProtKB: G5B8I3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021117434   ⟸   XM_021261775
- Peptide Label: isoform X4
- UniProtKB: G5B8I3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021117432   ⟸   XM_021261773
- Peptide Label: isoform X2
- UniProtKB: G5B8I3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004849051   ⟸   XM_004848994
- Peptide Label: isoform X7
- UniProtKB: G5B8I3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004849052   ⟸   XM_004848995
- Peptide Label: isoform X8
- UniProtKB: A0A0P6JHV9 (UniProtKB/TrEMBL),   G5B8I3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000023728   ⟸   ENSHGLT00000023946
Ensembl Acc Id: ENSHGLP00000023729   ⟸   ENSHGLT00000023947
Ensembl Acc Id: ENSHGLP00000023727   ⟸   ENSHGLT00000023945


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016929 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000023945 ENTREZGENE
  ENSHGLT00000023946 ENTREZGENE
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro CAMSAP_CH UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PH_Vav UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  VAV2_SH2 UniProtKB/TrEMBL
  VAV2_SH3_1 UniProtKB/TrEMBL
  VAV2_SH3_2 UniProtKB/TrEMBL
NCBI Gene Vav2 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2 UniProtKB/TrEMBL
  PROTEIN VAV UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  CAMSAP_CH UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
  PUA UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47576 UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0P6JHV9 ENTREZGENE, UniProtKB/TrEMBL
  G5B8I3 ENTREZGENE, UniProtKB/TrEMBL