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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:somatostatin signaling pathway
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Accession:PW:0000579 term browser browse the term
Definition:Somatostatin signaling through its receptors regulates processes such as proliferation, secretion and motility via inhibition of growth hormone and factor. The potential anti-tumor activity of somatostatin has led to the development and clinical use of its analogs.
Synonyms:related_synonym: SRIF;   somatotropin release inhibitory factor


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somatostatin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grk2 G protein-coupled receptor kinase 2 IEP RGD PMID:23073237 RGD:13792788 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:17021051 RGD:1641809 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 IDA RGD PMID:17021051 RGD:1641809 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J IDA RGD PMID:17021051 RGD:1641809 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IDA RGD PMID:17021051 RGD:1641809 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Sst somatostatin IDA RGD PMID:17021051 RGD:1641809 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173 		JBrowse link
G Sstr1 somatostatin receptor 1 IDA RGD PMID:17021051 RGD:1641809 NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2635
      hormone signaling pathway 624
        peptide and protein hormone signaling pathway 439
          somatostatin signaling pathway 7
paths to the root