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G2/M DNA damage checkpoint pathway - Ontology Report - Rat Genome Database

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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:G2/M DNA damage checkpoint pathway
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Accession:PW:0000384 term browser browse the term
Definition:The G2/M checkpoint pathways assure the genome is replicated only once per cell cycle. The checkpoints control for damaged and un-replicated DNA. Various DNA damage checkpoints lead to inhibition of the cyclin-dependent kinases that regulate the next cell cycle point.
Synonyms:related_synonym: G2/M DNA damage checkpoint;   mitotic G2 DNA damage checkpoint signaling

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G2/M DNA damage checkpoint pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 IEA RGD PMID: RGD:1358139 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 IEA RGD PMID: RGD:1358139 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Chek1 checkpoint kinase 1 IMP RGD PMID:11278490 RGD:2316109 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Trex1 three prime repair exonuclease 1 ISO RGD PMID:11721054 RGD:1580482 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3866
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1738
        cell cycle pathway 214
          cell cycle checkpoint pathway 131
            G2/M checkpoint pathway 4
              G2/M DNA damage checkpoint pathway 4
paths to the root