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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:insulin-like growth factor signaling pathway
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Accession:PW:0000238 term browser browse the term
Definition:Insulin-like growth factor signaling plays important roles in cell growth and proliferation. Produced primarily by the liver in response to stimulation by growth hormone (GH), the proteins activate cognate receptors to prompt intracellular signaling pathways and cell growth in a variety of tissues. Deregulation of the pathway has been associated with various conditions, including cancer.
Synonyms:related_synonym: insulin-like growth factor receptor signaling pathway


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insulin-like growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 ISO PID PID:200100 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756 		JBrowse link
G BAD BCL2 associated agonist of cell death ISO PID PID:200100 NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257 		JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member ISO PID PID:200100 NCBI chr16:55,798,578...55,838,448
Ensembl chr16:75,150,122...75,188,775 		JBrowse link
G CRK CRK proto-oncogene, adaptor protein ISO PID PID:200100 NCBI chr17:1,406,335...1,438,587
Ensembl chr17:1,306,509...1,336,569 		JBrowse link
G CRKL CRK like proto-oncogene, adaptor protein ISO PID PID:200100 NCBI chr22:3,141,147...3,177,448
Ensembl chr22:19,632,359...19,668,858 		JBrowse link
G ESR1 estrogen receptor 1 ISO RGD PMID:20042609 RGD:7242068 NCBI chr 6:149,507,599...149,918,523
Ensembl chr 6:154,317,002...154,631,551 		JBrowse link
G GRB10 growth factor receptor bound protein 10 ISO PID PID:200100 NCBI chr 7:51,230,945...51,434,560
Ensembl chr 7:51,474,166...51,666,638 		JBrowse link
G GRB2 growth factor receptor bound protein 2 ISO RGD
PID		 PMID:15272025 PID:200100 RGD:1581313 NCBI chr17:69,265,307...69,352,835
Ensembl chr17:74,817,471...74,903,796 		JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO PID PID:200100 NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078 		JBrowse link
G IGF1 insulin like growth factor 1 ISO RGD
PID		 PMID:7526037 PMID:15862547 PMID:16083987 PID:200100 RGD:12904768 RGD:1580473 RGD:1626333 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177 		JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO RGD
PID		 PMID:15272025 PMID:15862547 PMID:20042609 PID:200100 RGD:1581313 RGD:1626333 RGD:7242068 NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974 		JBrowse link
G IGF2 insulin like growth factor 2 ISO RGD PMID:15862547 RGD:1626333 NCBI chr11:2,170,190...2,199,442
Ensembl chr11:2,202,743...2,228,890 		JBrowse link
G IGFALS insulin like growth factor binding protein acid labile subunit ISO RGD PMID:15862547 RGD:1626333 NCBI chr16:412,671...418,351
Ensembl chr16:1,843,979...1,848,442 		JBrowse link
G IGFBP1 insulin like growth factor binding protein 1 ISO RGD PMID:15862547 RGD:1626333 NCBI chr 7:46,538,566...46,545,536
Ensembl chr 7:46,658,097...46,662,584 		JBrowse link
G IGFBP2 insulin like growth factor binding protein 2 ISO RGD PMID:15862547 RGD:1626333 NCBI chr2B:103,893,724...103,925,318 JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 ISO RGD PMID:15862547 RGD:1626333 NCBI chr 7:46,564,234...46,573,145 JBrowse link
G IGFBP4 insulin like growth factor binding protein 4 ISO RGD PMID:15862547 RGD:1626333 NCBI chr17:16,830,994...16,845,339 JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 ISO RGD PMID:15862547 RGD:1626333 NCBI chr2B:103,932,983...103,956,475
Ensembl chr2B:222,534,967...222,558,432 		JBrowse link
G IGFBP6 insulin like growth factor binding protein 6 ISO RGD PMID:15862547 RGD:1626333 NCBI chr12:35,654,172...35,659,115
Ensembl chr12:36,435,221...36,440,132 		JBrowse link
G IRS1 insulin receptor substrate 1 ISO PID
RGD		 PMID:15272025 PID:200100 RGD:1581313 NCBI chr2B:113,973,191...114,041,127
Ensembl chr2B:232,849,239...232,852,967 		JBrowse link
G IRS2 insulin receptor substrate 2 ISO PID PID:200100 NCBI chr13:90,886,095...90,917,724 JBrowse link
G NCK2 NCK adaptor protein 2 ISO PID PID:200100 NCBI chr2A:95,939,197...96,089,163
Ensembl chr2A:106,898,547...106,976,363 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO PID PID:200100 NCBI chr16:1,394,447...1,463,735 JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO PID PID:200100 NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200100 NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960 		JBrowse link
G PRKCD protein kinase C delta ISO PID PID:200100 NCBI chr 3:53,104,137...53,135,588
Ensembl chr 3:54,330,328...54,357,910 		JBrowse link
G PRKCZ protein kinase C zeta ISO PID PID:200100 NCBI chr 1:763,942...901,531
Ensembl chr 1:1,920,219...2,045,855 		JBrowse link
G PRKD1 protein kinase D1 ISO PID PID:200100 NCBI chr14:10,353,284...10,707,841
Ensembl chr14:28,496,282...28,650,030 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 ISO PID PID:200100 NCBI chr20:46,854,918...46,929,509
Ensembl chr20:47,983,098...48,057,421 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 ISO PID PID:200100 NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762 		JBrowse link
G PXN paxillin ISO PID PID:200100 NCBI chr12:117,785,614...117,840,816
Ensembl chr12:121,160,295...121,176,667 		JBrowse link
G RACK1 receptor for activated C kinase 1 ISO PID PID:200100 NCBI chr 5:176,462,991...176,470,153
Ensembl chr 5:183,712,665...183,720,128 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200100 NCBI chr 3:12,510,084...12,590,598
Ensembl chr 3:12,853,415...12,932,871 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 ISO PID PID:200100 NCBI chr17:53,958,807...54,014,752
Ensembl chr17:58,799,069...58,853,653 		JBrowse link
G SHC1 SHC adaptor protein 1 ISO PID PID:200100 NCBI chr 1:130,310,778...130,323,001
Ensembl chr 1:133,920,532...133,929,008 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200100 NCBI chr2A:39,019,046...39,162,248
Ensembl chr2A:39,773,760...39,911,961 		JBrowse link
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon ISO PID PID:200100 NCBI chr17:1,332,004...1,387,120
Ensembl chr17:1,229,080...1,285,470 		JBrowse link
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta ISO PID PID:200100 NCBI chr 8:97,560,251...97,595,117
Ensembl chr 8:99,730,393...99,762,990 		JBrowse link
altered insulin-like growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IGF1 insulin like growth factor 1 ISO RGD PMID:15996002 RGD:1580474 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    signaling pathway 1930
      growth factor signaling pathway 373
        insulin-like growth factor signaling pathway 38
          altered insulin-like growth factor signaling pathway 1
Path 2
Term Annotations click to browse term
  pathway 4064
    signaling pathway 1930
      hormone signaling pathway 380
        peptide and protein hormone signaling pathway 273
          insulin-like growth factor signaling pathway 38
            altered insulin-like growth factor signaling pathway 1
paths to the root