IGF2 (insulin like growth factor 2) - Rat Genome Database

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Gene: IGF2 (insulin like growth factor 2) Pan paniscus
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Symbol: IGF2
Name: insulin like growth factor 2
RGD ID: 11951839
Description: ENCODES a protein that exhibits growth factor activity (ortholog); insulin receptor binding (ortholog); insulin-like growth factor receptor binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); cellular response to mechanical stimulus (ortholog); embryonic placenta development (ortholog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); adrenocortical carcinoma (ortholog); Alcoholic Liver Diseases (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1112,202,764 - 2,228,890 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,202,743 - 2,228,890 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0112,170,190 - 2,199,442 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
adrenocortical carcinoma  (ISO)
Alcoholic Liver Diseases  (ISO)
alcoholic neuropathy  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
Animal Mammary Neoplasms  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
Beckwith-Wiedemann syndrome  (ISO)
bone development disease  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
choriocarcinoma  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Ia  (ISO)
developmental and epileptic encephalopathy  (ISO)
Diabetic Nephropathies  (ISO)
Diaphragmatic Hernia  (ISO)
early infantile epileptic encephalopathy  (ISO)
Embryo Loss  (ISO)
Ependymomas  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Fetal Growth Retardation  (ISO)
Gastrointestinal Diseases  (ISO)
Growth Disorders  (ISO)
Hepatic Echinococcosis  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hypoglycemia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
immunodeficiency 39  (ISO)
inflammatory bowel disease  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
Lung Injury  (ISO)
Memory Disorders  (ISO)
meningitis  (ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
multiple system atrophy  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
Nerve Degeneration  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
Parkinson's disease  (ISO)
placenta disease  (ISO)
polyhydramnios  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-malignant neoplasm  (ISO)
Radiation Injuries, Experimental  (ISO)
rhabdomyosarcoma  (ISO)
rheumatoid arthritis  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
Silver-Russell syndrome  (ISO)
Silver-Russell Syndrome 3  (ISO)
Spontaneous Abortions  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
ventricular septal defect  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
cellular response to mechanical stimulus  (ISO)
embryonic placenta development  (ISO)
embryonic placenta morphogenesis  (ISO)
exocrine pancreas development  (ISO)
female pregnancy  (ISO)
in utero embryonic development  (ISO)
insulin receptor signaling pathway via phosphatidylinositol 3-kinase  (ISO)
memory  (ISO)
negative regulation of muscle cell differentiation  (ISO)
negative regulation of natural killer cell mediated cytotoxicity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
osteoblast differentiation  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of glycogen (starch) synthase activity  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of steroid hormone biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
regulation of histone modification  (ISO)
regulation of muscle cell differentiation  (ISO)
response to drug  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to radiation  (ISO)
spongiotrophoblast cell proliferation  (ISO)
striated muscle cell differentiation  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
IGF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1112,202,764 - 2,228,890 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,202,743 - 2,228,890 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0112,170,190 - 2,199,442 (-)NCBIMhudiblu_PPA_v0panPan3
IGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl112,129,112 - 2,141,238 (-)EnsemblGRCh38hg38GRCh38
GRCh38112,129,117 - 2,149,566 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,150,342 - 2,170,833 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,106,923 - 2,127,409 (-)NCBINCBI36hg18NCBI36
Build 34112,110,531 - 2,116,578NCBI
Celera112,186,838 - 2,207,338 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef111,940,869 - 1,961,095 (-)NCBIHuRef
CHM1_1112,148,968 - 2,169,786 (-)NCBICHM1_1
Igf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,204,505 - 142,220,566 (-)NCBIGRCm39mm39
GRCm39 Ensembl7142,204,503 - 142,220,553 (-)Ensembl
GRCm387142,650,768 - 142,666,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,650,766 - 142,666,816 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,836,673 - 149,846,940 (-)NCBIGRCm37mm9NCBIm37
MGSCv367142,460,158 - 142,468,879 (-)NCBImm8
Celera7142,407,105 - 142,417,364 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.99NCBI
Igf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21197,814,409 - 197,831,802 (-)NCBI
Rnor_6.0 Ensembl1215,828,102 - 215,846,911 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01215,828,102 - 215,839,081 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01222,722,921 - 222,733,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,906,624 - 202,915,231 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11203,094,689 - 203,103,297 (-)NCBI
Celera1195,432,460 - 195,442,561 (-)NCBICelera
Cytogenetic Map1q41NCBI
Igf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,880,471 - 13,888,566 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542213,880,525 - 13,907,963 (-)NCBIChiLan1.0ChiLan1.0
IGF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,294,036 - 46,311,982 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,294,019 - 46,311,982 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,906,773 - 44,921,790 (-)NCBI
ROS_Cfam_1.01846,973,499 - 46,991,455 (-)NCBI
UMICH_Zoey_3.11846,425,198 - 46,440,216 (-)NCBI
UNSW_CanFamBas_1.01846,005,530 - 46,020,544 (-)NCBI
UU_Cfam_GSD_1.01846,751,952 - 46,766,988 (-)NCBI
Igf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,719,158 - 1,727,419 (-)NCBI
SpeTri2.0NW_004936816972,902 - 981,232 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.121,469,183 - 1,496,417 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap2pNCBI
IGF2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,937,414 - 1,951,238 (-)NCBI
ChlSab1.1 Ensembl11,936,830 - 1,945,388 (-)Ensembl
Igf2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476714,969,977 - 14,997,577 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000048267   ⟹   ENSPPAP00000025440
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl112,202,743 - 2,228,890 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000048270   ⟹   ENSPPAP00000025443
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl112,202,743 - 2,211,497 (-)Ensembl
RefSeq Acc Id: XM_003816063   ⟹   XP_003816111
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1112,202,764 - 2,207,420 (-)NCBI
Mhudiblu_PPA_v0112,170,190 - 2,178,365 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008969093   ⟹   XP_008967341
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1112,202,764 - 2,228,890 (-)NCBI
Mhudiblu_PPA_v0112,170,190 - 2,199,442 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024930725   ⟹   XP_024786493
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1112,202,764 - 2,207,402 (-)NCBI
Mhudiblu_PPA_v0112,173,485 - 2,178,359 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034931942   ⟹   XP_034787833
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0112,173,582 - 2,179,957 (-)NCBI
RefSeq Acc Id: XM_034931943   ⟹   XP_034787834
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0112,173,485 - 2,178,349 (-)NCBI
RefSeq Acc Id: XM_034931944   ⟹   XP_034787835
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0112,170,190 - 2,180,465 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_008967341   ⟸   XM_008969093
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003816111   ⟸   XM_003816063
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_024786493   ⟸   XM_024930725
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034787835   ⟸   XM_034931944
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034787834   ⟸   XM_034931943
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034787833   ⟸   XM_034931942
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000025440   ⟸   ENSPPAT00000048267
RefSeq Acc Id: ENSPPAP00000025443   ⟸   ENSPPAT00000048270
Protein Domains
IlGF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035852 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000025440 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000025443 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000048267 UniProtKB/TrEMBL
  ENSPPAT00000048270 UniProtKB/TrEMBL
InterPro IGF2 UniProtKB/TrEMBL
  IGF2_C UniProtKB/TrEMBL
  Insulin-like UniProtKB/TrEMBL
  Insulin-like_growth_factor UniProtKB/TrEMBL
  Insulin-like_sf UniProtKB/TrEMBL
  Insulin_CS UniProtKB/TrEMBL
  Insulin_family UniProtKB/TrEMBL
KEGG Report pps:100968468 UniProtKB/TrEMBL
NCBI Gene IGF2 ENTREZGENE
Pfam IGF2_C UniProtKB/TrEMBL
  Insulin UniProtKB/TrEMBL
PRINTS INSLNLIKEGF UniProtKB/TrEMBL
  INSLNLIKEGF2 UniProtKB/TrEMBL
  INSULINFAMLY UniProtKB/TrEMBL
PROSITE INSULIN UniProtKB/TrEMBL
SMART IlGF UniProtKB/TrEMBL
Superfamily-SCOP SSF56994 UniProtKB/TrEMBL
UniProt A0A2R9B770_PANPA UniProtKB/TrEMBL
  A0A2R9BAY3_PANPA UniProtKB/TrEMBL