Any process that stops, prevents or reduces the frequency, rate or extent of inward rectifier potassium channel activity.
Synonyms:
exact_synonym:
down regulation of Kir channel activity; down regulation of inward rectifier potassium channel activity; downregulation of Kir channel activity; downregulation of inward rectifier potassium channel activity; negative regulation of Kir channel activity
narrow_synonym:
inhibition of Kir channel activity; inhibition of inward rectifier potassium channel activity