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ONTOLOGY REPORT - ANNOTATIONS

Term:secondary piRNA processing
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Accession:GO:0140965 term browser browse the term
Definition:A process leading to the generation of a functional secondary piRNA, involving a self-perpetuating piRNA loop, often called the ping-pong cycle, in which piRNAs are amplified by pairing with complementary transcripts (for example the transposable element mRNA target). In Drosophila, the processing involves the piwi proteins aubergine and Argonaute 3 and in mice, the piwi proteins Piwil2 and Piwil4.
Synonyms:exact_synonym: ping-pong derived piRNA;   secondary PIWI-associated RNA processing;   secondary piRNA biogenesis
 related_synonym: ping-pong amplification

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secondary piRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx4 DEAD-box helicase 4 involved_in ISO (MGI:5908740|PMID:28633017) UniProt PMID:28633017 MGI:5908740 NCBI chrNW_004955446:11,967,222...12,025,537
Ensembl chrNW_004955446:11,967,322...12,024,587 		JBrowse link
G Piwil2 piwi like RNA-mediated gene silencing 2 involved_in ISO (MGI:3815367|PMID:18922463), (MGI:5908740|PMID:28633017) UniProt PMID:18922463 PMID:28633017 MGI:3815367 MGI:5908740 NCBI chrNW_004955403:45,737,674...45,819,478
Ensembl chrNW_004955403:45,737,674...45,819,873 		JBrowse link
G Piwil4 piwi like RNA-mediated gene silencing 4 involved_in ISO (MGI:3815367|PMID:18922463) UniProt PMID:18922463 MGI:3815367 NCBI chrNW_004955605:331,633...398,528 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12362
    metabolic process 7488
      primary metabolic process 6455
        RNA processing 583
          regulatory ncRNA processing 62
            piRNA processing 17
              secondary piRNA processing 3
Path 2
Term Annotations click to browse term
  biological_process 12362
    biological regulation 8888
      regulation of biological process 8622
        regulation of metabolic process 4805
          regulation of biosynthetic process 3814
            regulation of cellular biosynthetic process 3730
              regulation of macromolecule biosynthetic process 3637
                regulation of gene expression 3526
                  negative regulation of gene expression 967
                    regulatory ncRNA-mediated gene silencing 97
                      regulatory ncRNA processing 62
                        piRNA processing 17
                          secondary piRNA processing 3
paths to the root