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ONTOLOGY REPORT - ANNOTATIONS

Term:target-directed miRNA degradation
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Accession:GO:0140958 term browser browse the term
Definition:The process in which a miRNA is targeted for degradation by a non-coding RNA or mRNA. The binding of an RNA to a target miRNA within a RISC complex results in either ubiquitin-mediated degradation of AGO protein or the displacement of the 3' end of the miRNA, exposing it to nucleases.
Synonyms:exact_synonym: TDMD;   target-directed microRNA degradation


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target-directed miRNA degradation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elob elongin B involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr17:24,043,714...24,048,083
Ensembl chr17:24,043,712...24,048,110 		JBrowse link
G Eloc elongin C involved_in ISO GO_Central GO_REF:0000119 NCBI chr 1:16,711,949...16,727,652
Ensembl chr 1:16,711,949...16,727,266 		JBrowse link
G Oip5os1 Opa interacting protein 5, opposite strand 1 involved_in ISO (PMID:33184237) FlyBase PMID:33184237 NCBI chr 2:119,424,777...119,431,227
Ensembl chr 2:119,424,396...119,437,983 		JBrowse link
G Tent2 terminal nucleotidyltransferase 2 involved_in IMP (PMID:29887379) FlyBase PMID:29887379 NCBI chr13:93,282,363...93,330,662
Ensembl chr13:93,282,790...93,328,893 		JBrowse link
G Zswim8 zinc finger SWIM-type containing 8 involved_in ISO GO_Central GO_REF:0000119 NCBI chr14:20,756,346...20,773,687
Ensembl chr14:20,757,620...20,773,687 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28635
    negative regulation of biological process 6094
      negative regulation of post-transcriptional gene silencing 19
        negative regulation of post-transcriptional gene silencing by regulatory ncRNA 19
          negative regulation of miRNA-mediated gene silencing 18
            target-directed miRNA degradation 5
Path 2
Term Annotations click to browse term
  biological_process 28635
    biological regulation 13440
      regulation of biological process 13004
        regulation of cellular process 12619
          negative regulation of cellular process 5841
            negative regulation of metabolic process 3395
              negative regulation of macromolecule metabolic process 3137
                negative regulation of macromolecule biosynthetic process 2589
                  negative regulation of gene expression 1529
                    regulatory ncRNA-mediated gene silencing 406
                      regulatory ncRNA-mediated post-transcriptional gene silencing 341
                        regulation of post-transcriptional gene silencing by regulatory ncRNA 36
                          negative regulation of post-transcriptional gene silencing by regulatory ncRNA 19
                            negative regulation of miRNA-mediated gene silencing 18
                              target-directed miRNA degradation 5
paths to the root