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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:granzyme-mediated programmed cell death signaling pathway
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Accession:GO:0140507 term browser browse the term
Definition:The series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells.
Synonyms:broad_synonym: granzyme-mediated cell death signaling pathway

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granzyme-mediated programmed cell death signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bnip3 BCL2 interacting protein 3 involved_in ISO (PMID:9396766) GO_Central PMID:9396766 NCBI chrNW_004624737:14,848,355...14,863,731
Ensembl chrNW_004624737:14,848,350...14,862,965 		JBrowse link
G Gsdme gasdermin E involved_in ISO (PMID:31953257), (PMID:32188940) UniProt PMID:31953257 PMID:32188940 NCBI chrNW_004624739:5,790,372...5,879,979
Ensembl chrNW_004624739:5,798,771...5,871,088 		JBrowse link
G Gzma granzyme A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624759:4,177,857...4,185,325
Ensembl chrNW_004624759:4,177,857...4,185,324 		JBrowse link
G Lamp1 lysosomal associated membrane protein 1 involved_in ISO (PMID:23632890) GO_Central PMID:23632890 NCBI chrNW_004624793:661,322...675,603
Ensembl chrNW_004624793:661,342...675,675 		JBrowse link
G LOC101702156 granzyme B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624820:7,882,992...7,889,155
Ensembl chrNW_004624820:7,883,084...7,889,155 		JBrowse link
G Nkg7 natural killer cell granule protein 7 involved_in ISO (MGI:6810811|PMID:33911019) UniProt PMID:33911019 MGI:6810811 NCBI chrNW_004624832:3,501,924...3,502,750
Ensembl chrNW_004624832:3,501,973...3,504,773 		JBrowse link
G Prf1 perforin 1 involved_in ISO (PMID:35705808) UniProt PMID:35705808 NCBI chrNW_004624754:4,679,451...4,681,627
Ensembl chrNW_004624754:4,679,521...4,681,627 		JBrowse link
G Srgn serglycin involved_in ISO (PMID:11911826) GO_Central PMID:11911826 NCBI chrNW_004624754:3,379,651...3,412,175
Ensembl chrNW_004624754:3,401,480...3,411,488 		JBrowse link
granzyme-mediated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ube4b ubiquitination factor E4B involved_in ISO (PMID:11802788) UniProt PMID:11802788 NCBI chrNW_004624818:2,448,809...2,561,947
Ensembl chrNW_004624818:2,447,368...2,562,128 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15052
    cellular process 14191
      signal transduction 5392
        granzyme-mediated programmed cell death signaling pathway 9
          granzyme-mediated apoptotic signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 15052
    biological regulation 10584
      regulation of biological process 10273
        signaling 5883
          signal transduction 5392
            granzyme-mediated programmed cell death signaling pathway 9
              granzyme-mediated apoptotic signaling pathway 1
paths to the root