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ONTOLOGY REPORT - ANNOTATIONS

Term:ligand-gated calcium channel activity
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Accession:GO:0099604 term browser browse the term
Definition:Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

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ligand-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcoln1 mucolipin TRP cation channel 1 enables ISO (PMID:25720963), (PMID:29019983) UniProt PMID:25720963 PMID:29019983 NCBI chrNW_004624828:634,318...643,406
Ensembl chrNW_004624828:634,214...643,633 		JBrowse link
G P2rx1 purinergic receptor P2X 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624786:6,503,367...6,520,802
Ensembl chrNW_004624786:6,504,250...6,521,821 		JBrowse link
G P2rx4 purinergic receptor P2X 4 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624747:21,783,445...21,796,501
Ensembl chrNW_004624747:21,783,381...21,796,260 		JBrowse link
G Trpm2 transient receptor potential cation channel subfamily M member 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624745:29,757,267...29,809,607
Ensembl chrNW_004624745:29,757,106...29,806,795 		JBrowse link
G Trpm4 transient receptor potential cation channel subfamily M member 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624832:4,902,335...4,937,806
Ensembl chrNW_004624832:4,902,659...4,936,926 		JBrowse link
G Trpm5 transient receptor potential cation channel subfamily M member 5 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624767:15,215,714...15,236,189
Ensembl chrNW_004624767:15,216,123...15,232,200 		JBrowse link
G Trpm8 transient receptor potential cation channel subfamily M member 8 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624847:180,040...320,494
Ensembl chrNW_004624847:194,497...320,600 		JBrowse link
calcium-induced calcium release activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bnip1 BCL2 interacting protein 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624733:16,885,430...16,941,536
Ensembl chrNW_004624733:16,925,294...16,941,839 		JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel enables ISO (PMID:11854751) BHF-UCL PMID:11854751 NCBI chrNW_004624872:4,539,965...4,592,004
Ensembl chrNW_004624872:4,539,847...4,594,793 		JBrowse link
G Ryr1 ryanodine receptor 1 enables ISO (PMID:26115329) UniProt PMID:26115329 NCBI chrNW_004624794:11,888,211...12,004,457
Ensembl chrNW_004624794:11,888,289...12,004,314 		JBrowse link
G Ryr2 ryanodine receptor 2 enables ISO (PMID:17921453) BHF-UCL
RGD		 PMID:17921453 PMID:18799678 RGD:7175259 NCBI chrNW_004624775:12,954,653...13,650,449
Ensembl chrNW_004624775:12,956,042...13,419,381 		JBrowse link
G Ryr3 ryanodine receptor 3 ISO RGD PMID:18799678 RGD:7175259 NCBI chrNW_004624804:467,207...1,030,873
Ensembl chrNW_004624804:467,295...1,030,212 		JBrowse link
glutamate-gated calcium ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 enables ISO PMID:1709304
PMID:11773314		 UniProt PMID:1709304 PMID:11773314 RGD:401966868 RGD:401966871 NCBI chrNW_004624733:35,337,039...35,648,184
Ensembl chrNW_004624733:35,339,683...35,647,349 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 enables ISO PMID:11773314 UniProt PMID:11773314 RGD:401966871 NCBI chrNW_004624848:1,132,939...1,261,110
Ensembl chrNW_004624848:1,135,032...1,261,087 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 enables ISO PMID:1709304 UniProt PMID:1709304 RGD:401966868 NCBI chrNW_004624797:1,775,105...2,167,651
Ensembl chrNW_004624797:1,775,071...2,169,286 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 enables ISO PMID:12873388
PMID:11425885		 UniProt PMID:11425885 PMID:12873388 RGD:405650374 RGD:405650399 NCBI chrNW_004624745:17,592,587...17,986,863
Ensembl chrNW_004624745:17,592,874...17,986,759 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 enables ISO PMID:7681676
(PMID:20007474), (PMID:7681676)		 UniProt PMID:7681676 PMID:20007474 RGD:405650269 NCBI chrNW_004624810:2,731,573...3,407,186
Ensembl chrNW_004624810:2,733,118...3,401,909 		JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 enables ISO (PMID:20007474) UniProt PMID:20007474 NCBI chrNW_004624764:19,649,780...19,860,077
Ensembl chrNW_004624764:19,655,782...19,860,119 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 enables ISO (PMID:28126851), (PMID:7679115) UniProt PMID:7679115 PMID:28126851 NCBI chrNW_004624760:777,208...800,525
Ensembl chrNW_004624760:776,873...801,354 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A enables ISO (PMID:26875626)
(PMID:27839871)		 UniProt PMID:26875626 PMID:27839871 NCBI chrNW_004624824:7,128,169...7,513,360
Ensembl chrNW_004624824:7,137,909...7,507,910 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B enables ISO (PMID:27839871)
(PMID:26875626)		 UniProt PMID:26875626 PMID:27839871 NCBI chrNW_004624752:24,008,520...24,480,834
Ensembl chrNW_004624752:24,135,487...24,459,288 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D enables ISO (PMID:26875626) UniProt PMID:26875626 NCBI chrNW_004624832:5,362,046...5,392,988
Ensembl chrNW_004624832:5,362,046...5,392,973 		JBrowse link
inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itpr1 inositol 1,4,5-trisphosphate receptor type 1 enables ISO (PMID:11117745) SynGO PMID:11117745 NCBI chrNW_004624773:14,856,803...15,193,173
Ensembl chrNW_004624773:14,856,804...15,193,168 		JBrowse link
inositol 1,4,5-trisphosphate-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itpr1 inositol 1,4,5-trisphosphate receptor type 1 enables ISO
IEA		 RGD
UniProt
InterPro		 PMID:15533917 PMID:19036964 GO_REF:0000002 GO_REF:0000104 GO_REF:0000117 RGD:6480876 RGD:7175271 NCBI chrNW_004624773:14,856,803...15,193,173
Ensembl chrNW_004624773:14,856,804...15,193,168 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor type 2 enables ISO
IEA		 RGD
InterPro
UniProt		 PMID:10969001 PMID:15533917 GO_REF:0000002 GO_REF:0000104 GO_REF:0000117 RGD:7175271 RGD:7175277 NCBI chrNW_004624752:12,360,796...12,820,042
Ensembl chrNW_004624752:12,360,740...12,822,287 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor type 3 enables ISO
IEA		 RGD
UniProt
InterPro		 PMID:10694253 PMID:15533917 PMID:17320950 PMID:17373911 GO_REF:0000002 GO_REF:0000104 GO_REF:0000117 RGD:2290285 RGD:7175265 RGD:7175268 RGD:7175271 NCBI chrNW_004624754:23,228,690...23,281,552
Ensembl chrNW_004624754:23,229,281...23,281,621 		JBrowse link
intracellularly gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itpr1 inositol 1,4,5-trisphosphate receptor type 1 enables ISO (PMID:20813840) UniProt PMID:20813840 NCBI chrNW_004624773:14,856,803...15,193,173
Ensembl chrNW_004624773:14,856,804...15,193,168 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor type 2 enables ISO (PMID:8063813) MGI PMID:8063813 NCBI chrNW_004624752:12,360,796...12,820,042
Ensembl chrNW_004624752:12,360,740...12,822,287 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor type 3 enables ISO (PMID:20813840) UniProt PMID:20813840 NCBI chrNW_004624754:23,228,690...23,281,552
Ensembl chrNW_004624754:23,229,281...23,281,621 		JBrowse link
G Ryr2 ryanodine receptor 2 enables ISO (PMID:17921453)
(PMID:10473538)		 BHF-UCL
UniProt		 PMID:10473538 PMID:17921453 NCBI chrNW_004624775:12,954,653...13,650,449
Ensembl chrNW_004624775:12,956,042...13,419,381 		JBrowse link
G Ryr3 ryanodine receptor 3 enables ISO (PMID:9395096) UniProt PMID:9395096 NCBI chrNW_004624804:467,207...1,030,873
Ensembl chrNW_004624804:467,295...1,030,212 		JBrowse link
G Trpa1 transient receptor potential cation channel subfamily A member 1 enables ISO (PMID:25855297)
(PMID:20547126)		 UniProt PMID:20547126 PMID:25855297 NCBI chrNW_004624744:18,997,273...19,042,838
Ensembl chrNW_004624744:18,997,462...19,042,227 		JBrowse link
G Trpm2 transient receptor potential cation channel subfamily M member 2 enables ISO (PMID:27068538) UniProt PMID:27068538 NCBI chrNW_004624745:29,757,267...29,809,607
Ensembl chrNW_004624745:29,757,106...29,806,795 		JBrowse link
G Trpv1 transient receptor potential cation channel subfamily V member 1 enables ISO PMID:17582331 UniProt PMID:17582331 RGD:8553505 NCBI chrNW_004624786:6,231,494...6,249,001
Ensembl chrNW_004624786:6,231,494...6,249,001 		JBrowse link
NAADP-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcoln1 mucolipin TRP cation channel 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:17613490 GO_REF:0000118 RGD:7205504 NCBI chrNW_004624828:634,318...643,406
Ensembl chrNW_004624828:634,214...643,633 		JBrowse link
G Mcoln2 mucolipin TRP cation channel 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624742:12,527,562...12,591,797
Ensembl chrNW_004624742:12,527,608...12,591,518 		JBrowse link
G Mcoln3 mucolipin TRP cation channel 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624742:12,469,007...12,504,604
Ensembl chrNW_004624742:12,469,132...12,504,809 		JBrowse link
G Tpcn1 two pore segment channel 1 NOT|enables ISO (PMID:24776928)
(PMID:19620632)		 UniProt PMID:19620632 PMID:24776928 NCBI chrNW_004624747:19,179,378...19,237,799
Ensembl chrNW_004624747:19,179,575...19,236,206 		JBrowse link
G Tpcn2 two pore segment channel 2 enables
NOT|enables		 ISO (PMID:19387438), (PMID:19620632), (PMID:20880839), (PMID:32167471)
(PMID:23063126)
(PMID:19557428)
(PMID:20495006), (PMID:25144390)		 UniProt PMID:19387438 PMID:19557428 PMID:19620632 PMID:20495006 PMID:20880839 More... NCBI chrNW_004624767:17,877,791...17,944,190
Ensembl chrNW_004624767:17,918,080...17,944,653 		JBrowse link
ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ryr1 ryanodine receptor 1 enables ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro		 PMID:19230144 GO_REF:0000002 GO_REF:0000117 GO_REF:0000118 RGD:7175256 NCBI chrNW_004624794:11,888,211...12,004,457
Ensembl chrNW_004624794:11,888,289...12,004,314 		JBrowse link
G Ryr2 ryanodine receptor 2 enables ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro		 PMID:18799678 PMID:21807619 GO_REF:0000002 GO_REF:0000117 GO_REF:0000118 RGD:7175254 RGD:7175259 NCBI chrNW_004624775:12,954,653...13,650,449
Ensembl chrNW_004624775:12,956,042...13,419,381 		JBrowse link
G Ryr3 ryanodine receptor 3 enables ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro		 PMID:18799678 GO_REF:0000002 GO_REF:0000117 GO_REF:0000118 RGD:7175259 NCBI chrNW_004624804:467,207...1,030,873
Ensembl chrNW_004624804:467,295...1,030,212 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 16462
    transporter activity 1084
      transmembrane transporter activity 993
        monoatomic ion transmembrane transporter activity 678
          monoatomic ion channel activity 411
            monoatomic cation channel activity 309
              calcium channel activity 107
                ligand-gated calcium channel activity 31
                  glutamate-gated calcium ion channel activity 10
                  intracellularly gated calcium channel activity + 16
                  pH-gated calcium channel activity 0
Path 2
Term Annotations click to browse term
  molecular_function 16462
    transporter activity 1084
      transmembrane transporter activity 993
        passive transmembrane transporter activity 463
          channel activity 463
            gated channel activity 308
              ligand-gated channel activity 187
                ligand-gated monoatomic ion channel activity 182
                  ligand-gated monoatomic cation channel activity 125
                    ligand-gated calcium channel activity 31
                      glutamate-gated calcium ion channel activity 10
                      intracellularly gated calcium channel activity + 16
                      pH-gated calcium channel activity 0
paths to the root