Grin2a (glutamate ionotropic receptor NMDA type subunit 2A) - Rat Genome Database

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Gene: Grin2a (glutamate ionotropic receptor NMDA type subunit 2A) Heterocephalus glaber
Analyze
Symbol: Grin2a
Name: glutamate ionotropic receptor NMDA type subunit 2A
RGD ID: 18933700
Description: ENCODES a protein that exhibits ATPase binding (ortholog); calcium channel activity (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN action potential (ortholog); auditory behavior (ortholog); calcium ion transmembrane import into cytosol (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); Alzheimer's disease (ortholog); autistic disorder (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); dendrite membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glutamate receptor ionotropic, NMDA 2A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248247,137,909 - 7,507,910 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248247,128,169 - 7,513,360 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol dependence  (ISO)
Alzheimer's disease  (ISO)
autistic disorder  (ISO)
autosomal dominant intellectual developmental disorder 21  (ISO)
benign epilepsy with centrotemporal spikes  (ISO)
bipolar disorder  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Central Nervous System Viral Diseases  (ISO)
Charcot-Marie-Tooth disease type 1C  (ISO)
cognitive disorder  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
developmental and epileptic encephalopathy 11  (ISO)
Developmental Disabilities  (ISO)
epilepsy  (ISO)
familial temporal lobe epilepsy 1  (ISO)
Fetal Growth Retardation  (ISO)
focal epilepsy  (ISO)
Focal Epilepsy with Speech Disorder and with or without Mental Retardation  (ISO)
GABA aminotransferase deficiency  (ISO)
Generalized Epilepsy  (ISO)
genetic disease  (ISO)
heroin dependence  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hyperhomocysteinemia  (ISO)
intellectual disability  (ISO)
Landau-Kleffner syndrome  (ISO)
Language Development Disorders  (ISO)
melanoma  (ISO)
MHC class II deficiency  (ISO)
microcephaly  (ISO)
morphine dependence  (ISO)
nasopharynx carcinoma  (ISO)
neonatal abstinence syndrome  (ISO)
Neuralgia  (ISO)
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES  (ISO)
Neurodevelopmental Disorders  (ISO)
opioid abuse  (ISO)
placental insufficiency  (ISO)
post-traumatic stress disorder  (ISO)
pyridoxine-dependent epilepsy  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
speech disorder  (ISO)
status epilepticus  (ISO)
Tinnitus  (ISO)
transient cerebral ischemia  (ISO)
vascular dementia  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (ISO)
auditory behavior  (ISO)
calcium ion transmembrane import into cytosol  (ISO)
calcium ion transmembrane transport  (ISO)
calcium ion transport  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to dsRNA  (ISO)
cellular response to glycine  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to lipid  (ISO)
cellular response to magnesium ion  (ISO)
cellular response to manganese ion  (ISO)
cellular response to zinc ion  (ISO)
cerebral cortex development  (ISO)
chemical synaptic transmission  (ISO)
conditioned place preference  (ISO)
dendritic spine organization  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
directional locomotion  (ISO)
dopamine metabolic process  (ISO)
excitatory postsynaptic potential  (ISO)
glutamate receptor signaling pathway  (ISO)
hippocampus development  (ISO)
ionotropic glutamate receptor signaling pathway  (ISO)
learning  (ISO)
learning or memory  (ISO)
locomotion  (ISO)
long-term synaptic potentiation  (ISO)
memory  (ISO)
modulation of chemical synaptic transmission  (ISO)
modulation of excitatory postsynaptic potential  (ISO)
monoatomic cation transmembrane transport  (ISO)
multicellular organismal response to stress  (ISO)
negative regulation of protein catabolic process  (ISO)
neurogenesis  (ISO)
neuron development  (ISO)
neurotransmitter receptor transport, plasma membrane to endosome  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of inhibitory postsynaptic potential  (ISO)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
protein catabolic process  (ISO)
protein localization to postsynaptic membrane  (ISO)
receptor recycling  (ISO)
regulation of ARF protein signal transduction  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of membrane potential  (ISO)
regulation of monoatomic cation transmembrane transport  (ISO)
regulation of NMDA receptor activity  (ISO)
regulation of postsynaptic membrane potential  (ISO)
regulation of response to alcohol  (ISO)
regulation of synaptic plasticity  (ISO)
response to amine  (ISO)
response to ammonium ion  (ISO)
response to amphetamine  (ISO)
response to calcium ion  (ISO)
response to carbohydrate  (ISO)
response to cocaine  (ISO)
response to environmental enrichment  (ISO)
response to ethanol  (ISO)
response to fungicide  (ISO)
response to glycoside  (ISO)
response to hydrogen sulfide  (ISO)
response to lead ion  (ISO)
response to light stimulus  (ISO)
response to lithium ion  (ISO)
response to manganese ion  (ISO)
response to methylmercury  (ISO)
response to nicotine  (ISO)
response to other organism  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
rhythmic process  (ISO)
sensory perception of pain  (ISO)
serotonin metabolic process  (ISO)
sleep  (ISO)
sodium ion transmembrane transport  (ISO)
spinal cord development  (ISO)
startle response  (ISO)
visual learning  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway   (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term depression  (ISO)
long term potentiation  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway   (ISO)
Reelin signaling pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Grin2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248247,137,909 - 7,507,910 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248247,128,169 - 7,513,360 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GRIN2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38169,753,404 - 10,182,908 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl169,753,404 - 10,183,337 (-)EnsemblGRCh38hg38GRCh38
GRCh37169,847,261 - 10,276,765 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36169,762,923 - 10,184,112 (-)NCBINCBI36Build 36hg18NCBI36
Build 34169,762,922 - 10,184,112NCBI
Celera1610,014,039 - 10,444,548 (-)NCBICelera
Cytogenetic Map16p13.2NCBI
HuRef169,767,577 - 9,952,307 (-)NCBIHuRef
HuRef1610,193,124 - 10,195,907 (-)NCBIHuRef
CHM1_1169,847,229 - 10,277,115 (-)NCBICHM1_1
T2T-CHM13v2.0169,786,917 - 10,217,640 (-)NCBIT2T-CHM13v2.0
Grin2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39169,385,765 - 9,813,744 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl169,385,762 - 9,813,424 (-)EnsemblGRCm39 Ensembl
GRCm38169,567,901 - 9,996,083 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl169,567,898 - 9,995,560 (-)EnsemblGRCm38mm10GRCm38
MGSCv37169,577,803 - 9,992,626 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36169,491,265 - 9,906,111 (-)NCBIMGSCv36mm8
Celera1610,217,398 - 10,625,063 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.28NCBI
Grin2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8106,136,458 - 6,560,003 (+)NCBIGRCr8
mRatBN7.2105,629,683 - 6,053,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl105,631,369 - 6,044,637 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1010,321,074 - 10,740,259 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0109,846,997 - 10,269,259 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0105,478,407 - 5,901,217 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0105,707,806 - 6,123,568 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl105,930,298 - 6,119,990 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0104,523,233 - 4,940,912 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4105,588,229 - 6,004,780 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1105,588,940 - 6,006,076 (+)NCBI
Celera104,645,710 - 5,048,399 (+)NCBICelera
Cytogenetic Map10q11NCBI
Grin2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554428,174,232 - 8,562,059 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554428,171,114 - 8,565,187 (+)NCBIChiLan1.0ChiLan1.0
GRIN2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21810,282,307 - 10,710,062 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11614,057,703 - 14,490,979 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0168,682,169 - 9,105,581 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1169,909,406 - 10,339,147 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl169,919,143 - 10,336,167 (-)Ensemblpanpan1.1panPan2
GRIN2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1632,132,070 - 32,678,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl632,303,121 - 32,668,960 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha633,514,238 - 34,067,205 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0632,315,346 - 32,865,008 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl632,484,833 - 32,856,871 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1632,128,354 - 32,680,283 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0632,000,797 - 32,549,532 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0632,426,676 - 32,972,580 (+)NCBIUU_Cfam_GSD_1.0
Grin2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344110,432,891 - 110,765,991 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365308,287,574 - 8,608,343 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365308,286,101 - 8,612,183 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl332,750,700 - 33,143,499 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1332,749,329 - 33,149,350 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2333,810,701 - 33,913,481 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRIN2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.159,233,028 - 9,707,322 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl59,286,775 - 9,462,828 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606820,460,991 - 20,885,559 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000026165   ⟹   ENSHGLP00000025936
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248247,137,909 - 7,507,910 (-)Ensembl
RefSeq Acc Id: XM_004864874   ⟹   XP_004864931
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248247,128,169 - 7,513,360 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004864931 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000025936
RefSeq Acc Id: XP_004864931   ⟸   XM_004864874
Ensembl Acc Id: ENSHGLP00000025936   ⟸   ENSHGLT00000026165


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018458 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000026165 ENTREZGENE
NCBI Gene Grin2a ENTREZGENE
UniProt A0AAX6Q4Q9_HETGA UniProtKB/TrEMBL