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ONTOLOGY REPORT - ANNOTATIONS

Term:histone H4K16 deacetylase activity, NAD-dependent
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Accession:GO:0046970 term browser browse the term
Definition:Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + NAD+ + H2O = histone H4 L-lysine (position 16) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H4K16 to NAD, producing nicotinamide.
Synonyms:exact_synonym: NAD-dependent histone H4-K16 deacetylase activity;   NAD-dependent histone deacetylase activity (H4-K16 specific)


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histone H4K16 deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SIRT1 sirtuin 1 enables IDA
IEA		 (PMID:15469825) BHF-UCL
UniProt		 PMID:15469825 GO_REF:0000003 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SIRT2 sirtuin 2 enables IDA
IEA		 (PMID:16648462) UniProt PMID:16648462 GO_REF:0000003 NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862 		JBrowse link
G SIRT3 sirtuin 3 enables IEA UniProt GO_REF:0000003 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
G SIRT6 sirtuin 6 enables IEA UniProt GO_REF:0000003 NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566 		JBrowse link
G SIRT7 sirtuin 7 enables IEA UniProt GO_REF:0000003 NCBI chr17:81,911,939...81,918,176
Ensembl chr17:81,911,939...81,921,323 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19683
    catalytic activity 6023
      catalytic activity, acting on a protein 2462
        protein lysine deacetylase activity 25
          histone deacetylase activity 25
            histone deacetylase activity, NAD-dependent 7
              histone H4K16 deacetylase activity, NAD-dependent 5
Path 2
Term Annotations click to browse term
  molecular_function 19683
    catalytic activity 6023
      deacylase activity 71
        deacetylase activity 40
          protein lysine deacetylase activity 25
            histone deacetylase activity 25
              histone deacetylase activity, NAD-dependent 7
                histone H4K16 deacetylase activity, NAD-dependent 5
paths to the root