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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of T-helper cell differentiation
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Accession:GO:0045624 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: up regulation of T-helper cell differentiation;   upregulation of T-helper cell differentiation
 narrow_synonym: activation of T-helper cell differentiation;   stimulation of T-helper cell differentiation
 related_synonym: positive regulation of T-helper cell development

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positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within ISO (PMID:24645804) MGI PMID:24645804 NCBI chrNW_004624825:3,846,604...3,972,780
Ensembl chrNW_004624825:3,845,092...3,973,636 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624811:765,338...782,203
Ensembl chrNW_004624811:764,940...782,198 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) BHF-UCL PMID:15845453 MGI:3576832 NCBI chrNW_004624736:39,088,741...39,090,745
Ensembl chrNW_004624736:39,088,921...39,090,394 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624835:4,223,252...4,227,892
Ensembl chrNW_004624835:4,223,511...4,227,979 		JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 acts_upstream_of_or_within ISO (PMID:11894097) MGI PMID:11894097 NCBI chrNW_004624744:2,194,339...2,227,498
Ensembl chrNW_004624744:2,201,319...2,226,890 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (MGI:3687909|PMID:12242343) UniProt PMID:12242343 MGI:3687909 NCBI chrNW_004624738:28,150,004...28,217,850
Ensembl chrNW_004624738:28,150,664...28,216,389 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624792:4,148,258...4,223,431
Ensembl chrNW_004624792:4,148,453...4,217,548 		JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624794:10,172,789...10,180,693
Ensembl chrNW_004624794:10,168,792...10,179,510 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624789:15,612,311...15,623,878
Ensembl chrNW_004624789:15,612,335...15,624,152 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) UniProt PMID:26098997 MGI:5689221 NCBI chrNW_004624937:564,191...584,470 JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISO (MGI:6106706|PMID:28262505)
(PMID:28262505)		 UniProt PMID:28262505 MGI:6106706 NCBI chrNW_004624754:23,742,506...23,750,668
Ensembl chrNW_004624754:23,742,509...23,750,062 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (MGI:6106706|PMID:28262505) UniProt PMID:28262505 MGI:6106706 NCBI chrNW_004624901:2,348,218...2,434,429
Ensembl chrNW_004624901:2,346,734...2,380,852 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624802:11,662,851...11,664,444
Ensembl chrNW_004624802:11,662,753...11,665,418 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624784:7,294,286...7,312,959
Ensembl chrNW_004624784:7,294,183...7,304,687 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624782:11,981,781...12,008,362 JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) UniProt PMID:26098997 MGI:5689221 NCBI chrNW_004624937:564,191...584,470 JBrowse link
G Prkcz protein kinase C zeta involved_in ISO (MGI:3584076|PMID:15987782) UniProt PMID:15987782 MGI:3584076 NCBI chrNW_004624818:7,758,192...7,846,950
Ensembl chrNW_004624818:7,759,770...7,847,208 		JBrowse link
G Rara retinoic acid receptor alpha involved_in ISO (PMID:18416830) BHF-UCL PMID:18416830 NCBI chrNW_004624795:2,935,432...2,975,226
Ensembl chrNW_004624795:2,934,731...2,967,232 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4943387|PMID:18354165) BHF-UCL PMID:18354165 MGI:4943387 NCBI chrNW_004624771:8,580,489...8,599,735 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    immune system process 2103
      immune effector process 553
        positive regulation of immune effector process 234
          positive regulation of T-helper cell differentiation 19
            positive regulation of T-helper 1 cell differentiation 5
            positive regulation of T-helper 17 cell differentiation + 7
            positive regulation of T-helper 2 cell differentiation 7
Path 2
Term Annotations click to browse term
  biological_process 15093
    cellular process 14237
      cellular developmental process 4122
        cell differentiation 4121
          cell development 2965
            hemopoiesis 926
              leukocyte differentiation 592
                mononuclear cell differentiation 482
                  lymphocyte differentiation 393
                    T cell differentiation 291
                      T cell differentiation involved in immune response 77
                        alpha-beta T cell differentiation involved in immune response 71
                          CD4-positive, alpha-beta T cell differentiation involved in immune response 70
                            T-helper cell differentiation 68
                              regulation of T-helper cell differentiation 38
                                positive regulation of T-helper cell differentiation 19
                                  positive regulation of T-helper 1 cell differentiation 5
                                  positive regulation of T-helper 17 cell differentiation + 7
                                  positive regulation of T-helper 2 cell differentiation 7
paths to the root