ONTOLOGY REPORT - ANNOTATIONS
Term: negative regulation of CD4-positive, alpha-beta T cell differentiation
Accession: GO:0043371
browse the term
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms: exact_synonym: down regulation of CD4-positive, alpha beta T cell differentiation; downregulation of CD4-positive, alpha beta T cell differentiation; negative regulation of CD4-positive T lymphocyte differentiation; negative regulation of CD4-positive T-cell differentiation; negative regulation of CD4-positive, alpha beta T lymphocyte differentiation
narrow_synonym: inhibition of CD4-positive, alpha beta T cell differentiation
related_synonym: negative regulation of CD4-positive, alpha beta T cell development
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Cbfb
core-binding factor subunit beta
involved_in
ISO
(MGI:3772948|PMID:18258917)
UniProt
PMID:18258917
MGI:3772948
NCBI chrNW_004955484:9,503,286...9,557,066
Ensembl chrNW_004955484:9,503,227...9,557,066
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Hmgb1
high mobility group box 1
involved_in
ISO
(PMID:22473704)
UniProt
PMID:22473704
NCBI chrNW_004955431:15,373,207...15,377,339
Ensembl chrNW_004955431:15,373,207...15,377,339
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Runx3
RUNX family transcription factor 3
involved_in
ISO
(MGI:3772948|PMID:18258917)
UniProt
PMID:18258917
MGI:3772948
NCBI chrNW_004955452:4,580,444...4,606,820
Ensembl chrNW_004955452:4,579,331...4,636,884
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Ascl2
achaete-scute family bHLH transcription factor 2
involved_in
ISO
(MGI:5565031|PMID:24463518)
UniProt
PMID:24463518
MGI:5565031
NCBI chrNW_004955422:14,051,140...14,053,521
Ensembl chrNW_004955422:14,051,140...14,053,521
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Il4r
interleukin 4 receptor
acts_upstream_of_or_within
ISO
(PMID:16424184)
MGI
PMID:16424184
NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422
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Jak3
Janus kinase 3
involved_in
ISO
(MGI:3719947|PMID:16020505)
BHF-UCL
PMID:16020505
MGI:3719947
NCBI chrNW_004955524:3,399,895...3,412,018
Ensembl chrNW_004955524:3,401,642...3,411,643
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Tnfsf4
TNF superfamily member 4
involved_in
ISO
(MGI:4942267|PMID:9670042)
BHF-UCL
PMID:9670042
MGI:4942267
NCBI chrNW_004955406:13,477,077...13,493,309
Ensembl chrNW_004955406:13,477,077...13,493,309
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Ascl2
achaete-scute family bHLH transcription factor 2
involved_in
ISO
(MGI:5565031|PMID:24463518)
UniProt
PMID:24463518
MGI:5565031
NCBI chrNW_004955422:14,051,140...14,053,521
Ensembl chrNW_004955422:14,051,140...14,053,521
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Foxp3
forkhead box P3
involved_in
ISO
(PMID:23169781)
UniProt
PMID:23169781
NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606
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Il2
interleukin 2
involved_in
ISO
(MGI:5634593|PMID:25642768)
BHF-UCL
PMID:25642768
MGI:5634593
NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265
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Il4
interleukin 4
acts_upstream_of_or_within
ISO
(PMID:18792410)
MGI
PMID:18792410
NCBI chrNW_004955408:4,058,052...4,065,999
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Rc3h1
ring finger and CCCH-type domains 1
involved_in
ISO
(MGI:6142401|PMID:25282160)
UniProt
PMID:25282160
MGI:6142401
NCBI chrNW_004955406:14,053,122...14,123,023
Ensembl chrNW_004955406:14,053,122...14,123,029
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Rc3h2
ring finger and CCCH-type domains 2
involved_in
ISO
(MGI:6142401|PMID:25282160)
UniProt
PMID:25282160
MGI:6142401
NCBI chrNW_004955419:5,054,288...5,103,926
Ensembl chrNW_004955419:5,054,289...5,103,926
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Smad7
SMAD family member 7
involved_in
ISO
(MGI:5634593|PMID:25642768)
BHF-UCL
PMID:25642768
MGI:5634593
NCBI chrNW_004955402:34,028,184...34,058,949
Ensembl chrNW_004955402:34,028,063...34,058,291
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Tbx21
T-box transcription factor 21
involved_in
ISO
(MGI:4868293|PMID:21151104)
UniProt
PMID:21151104
MGI:4868293
NCBI chrNW_004955451:13,315,237...13,317,888
Ensembl chrNW_004955451:13,315,859...13,325,937
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Zbtb7b
zinc finger and BTB domain containing 7B
acts_upstream_of_or_within
ISO
(PMID:23034280)
MGI
PMID:23034280
NCBI chrNW_004955545:1,504,656...1,519,954
Ensembl chrNW_004955545:1,503,514...1,521,003
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Zc3h12a
zinc finger CCCH-type containing 12A
involved_in
ISO
(MGI:6142401|PMID:25282160)
UniProt
PMID:25282160
MGI:6142401
NCBI chrNW_004955452:15,306,398...15,314,959
Ensembl chrNW_004955452:15,305,775...15,314,959
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Loxl3
lysyl oxidase like 3
involved_in
ISO
(MGI:5825383|PMID:28065600) (PMID:28065600)
UniProt
PMID:28065600
MGI:5825383
NCBI chrNW_004955424:11,236,415...11,255,801
Ensembl chrNW_004955424:11,236,836...11,259,570
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Tbx21
T-box transcription factor 21
involved_in
ISO
(MGI:4868293|PMID:21151104)
UniProt
PMID:21151104
MGI:4868293
NCBI chrNW_004955451:13,315,237...13,317,888
Ensembl chrNW_004955451:13,315,859...13,325,937
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Tnfsf18
TNF superfamily member 18
involved_in
ISO
(MGI:5551556|PMID:24107315)
UniProt
PMID:24107315
MGI:5551556
NCBI chrNW_004955406:13,391,162...13,402,479
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Anxa1
annexin A1
involved_in
ISO
(PMID:17008549)
UniProt
PMID:17008549
NCBI chrNW_004955512:5,686,508...5,703,645
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Ascl2
achaete-scute family bHLH transcription factor 2
involved_in
ISO
(MGI:5565031|PMID:24463518)
UniProt
PMID:24463518
MGI:5565031
NCBI chrNW_004955422:14,051,140...14,053,521
Ensembl chrNW_004955422:14,051,140...14,053,521
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Bcl6
BCL6 transcription repressor
acts_upstream_of_or_within
ISO
(PMID:12594267)
MGI
PMID:12594267
NCBI chrNW_004955420:19,998,960...20,021,200
Ensembl chrNW_004955420:19,998,742...20,022,259
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Hlx
H2.0 like homeobox
acts_upstream_of_or_within
ISO
(PMID:16424184)
MGI
PMID:16424184
NCBI chrNW_004955520:2,937,131...2,941,170
Ensembl chrNW_004955520:2,936,815...2,941,170
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Socs5
suppressor of cytokine signaling 5
involved_in
ISO
(MGI:3687909|PMID:12242343)
UniProt
PMID:12242343
MGI:3687909
NCBI chrNW_004955441:13,593,342...13,657,389
Ensembl chrNW_004955441:13,593,342...13,657,389
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Rc3h1
ring finger and CCCH-type domains 1
acts_upstream_of_or_within
ISO
(PMID:15917799)
MGI
PMID:15917799
NCBI chrNW_004955406:14,053,122...14,123,023
Ensembl chrNW_004955406:14,053,122...14,123,029
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
biological_process
12362
immune system process
1980
leukocyte activation
888
lymphocyte activation
720
T cell activation
507
alpha-beta T cell activation
177
CD4-positive, alpha-beta T cell activation
118
CD4-positive, alpha-beta T cell differentiation
91
negative regulation of CD4-positive, alpha-beta T cell differentiation
22
negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +
0
negative regulation of T-helper cell differentiation +
19
Path 2
biological_process
12362
cellular process
11484
cellular developmental process
3880
cell differentiation
3879
cell development
2838
hemopoiesis
920
leukocyte differentiation
592
mononuclear cell differentiation
483
lymphocyte differentiation
394
T cell differentiation
293
alpha-beta T cell differentiation
128
CD4-positive, alpha-beta T cell differentiation
91
regulation of CD4-positive, alpha-beta T cell differentiation
51
negative regulation of CD4-positive, alpha-beta T cell differentiation
22
negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +
0
negative regulation of T-helper cell differentiation +
19