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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-18-mediated signaling pathway
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Accession:GO:0035655 term browser browse the term
Definition:The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: interleukin-18-mediated signalling pathway


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interleukin-18-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193 		JBrowse link
G IL18 interleukin 18 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 (PMID:15843532) UniProt
MGI
Ensembl		 PMID:15843532 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348 		JBrowse link
G IL18R1 interleukin 18 receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10227969) Ensembl
TreeGrafter
MGI		 PMID:10227969 GO_REF:0000107 GO_REF:0000118 NCBI chr10:40,614,336...40,653,300
Ensembl chr10:40,615,312...40,653,454 		JBrowse link
G IL18RAP interleukin 18 receptor accessory protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15843532) Ensembl
TreeGrafter
MGI		 PMID:15843532 GO_REF:0000107 GO_REF:0000118 NCBI chr10:40,578,503...40,605,800
Ensembl chr10:40,581,096...40,605,766 		JBrowse link
G PDGFB platelet derived growth factor subunit B involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970 		JBrowse link
negative regulation of interleukin-18-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYLD CYLD lysine 63 deubiquitinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:64,561,684...64,628,829
Ensembl chr 2:64,562,503...64,628,175 		JBrowse link
positive regulation of interleukin-18-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP4 caspase 4, apoptosis-related cysteine peptidase involved_in ISO (PMID:33377178)
(MGI:6259277|PMID:30392956)		 UniProt PMID:30392956 PMID:33377178 MGI:6259277 NCBI chr 5:27,133,778...27,147,954
Ensembl chr 5:27,132,565...27,149,736 		JBrowse link
G NLRP6 NLR family pyrin domain containing 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:25,433,481...25,440,703
Ensembl chr18:25,433,698...25,440,740 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (MGI:5488868|PMID:22685567)
(PMID:22685567)		 UniProt PMID:22685567 MGI:5488868 NCBI chr11:5,312,383...5,313,099
Ensembl chr11:5,312,383...5,313,099 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17925
    cellular process 16910
      signal transduction 6317
        cell surface receptor signaling pathway 2807
          cytokine-mediated signaling pathway 493
            interleukin-18-mediated signaling pathway 10
              negative regulation of interleukin-18-mediated signaling pathway 1
              positive regulation of interleukin-18-mediated signaling pathway 3
              regulation of interleukin-18-mediated signaling pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 17925
    response to stimulus 9451
      response to chemical 5158
        response to peptide 1239
          response to cytokine 1215
            cellular response to cytokine stimulus 1079
              cytokine-mediated signaling pathway 493
                interleukin-18-mediated signaling pathway 10
                  negative regulation of interleukin-18-mediated signaling pathway 1
                  positive regulation of interleukin-18-mediated signaling pathway 3
                  regulation of interleukin-18-mediated signaling pathway + 4
paths to the root