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ONTOLOGY REPORT - ANNOTATIONS

Term:1-phosphatidylinositol-4-phosphate 3-kinase activity
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Accession:GO:0035005 term browser browse the term
Definition:Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + H+.
Synonyms:exact_synonym: phosphatidylinositol-4-phosphate 3-kinase activity
 narrow_synonym: C2-domain-containing phosphoinositide 3-kinase activity;   phosphatidylinositol 3-kinase activity, class I;   phosphatidylinositol 3-kinase activity, class II;   phosphatidylinositol 3-kinase, class I, catalyst activity
 related_synonym: ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity;   type II phosphoinositide 3-kinase activity
 xref: EC:2.7.1.154;   KEGG_REACTION:R05795;   MetaCyc:2.7.1.154-RXN;   RHEA:18373;   reactome:R-HSA-1675928 "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane";   reactome:R-HSA-1676109 "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane";   reactome:R-HSA-1676206 "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane";   reactome:R-HSA-8868072 "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2"


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1-phosphatidylinositol-4-phosphate 3-kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha enables ISO
IBA		 (PMID:10805725), (PMID:11239472), (PMID:9337861)
GO_REF:0000033		 RGD
GO_Central		 PMID:9337861 PMID:10805725 PMID:11239472 GO_REF:0000033 NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472 		JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta enables ISO
IBA		 (PMID:10805725), (PMID:9830063)
GO_REF:0000033		 RGD
GO_Central		 PMID:9830063 PMID:10805725 GO_REF:0000033 NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612 		JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma enables IDA
IEA
IBA
ISO		 GO_REF:0000003
GO_REF:0000033
(PMID:9514948)		 UniProt
GO_Central
RGD		 PMID:9514948 PMID:9516481 GO_REF:0000003 GO_REF:0000033, RGD:729517 NCBI chr 4:172,483,752...172,851,623
Ensembl chr 4:172,484,345...172,850,544 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma enables ISO
IBA		 (PMID:16123124)
GO_REF:0000033		 RGD
GO_Central		 PMID:16123124 GO_REF:0000033 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20627
    catalytic activity 6029
      transferase activity 2396
        transferase activity, transferring phosphorus-containing groups 968
          phosphotransferase activity, alcohol group as acceptor 732
            phosphatidylinositol kinase activity 25
              1-phosphatidylinositol-4-phosphate 3-kinase activity 7
Path 2
Term Annotations click to browse term
  molecular_function 20627
    catalytic activity 6029
      transferase activity 2396
        transferase activity, transferring phosphorus-containing groups 968
          kinase activity 801
            lipid kinase activity 40
              phosphatidylinositol kinase activity 25
                1-phosphatidylinositol-4-phosphate 3-kinase activity 7
paths to the root