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ONTOLOGY REPORT - ANNOTATIONS

Term:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
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Accession:GO:0034485 term browser browse the term
Definition:1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.
Synonyms:xref: EC:3.1.3.86;   MetaCyc:RXN-10036;   RHEA:25528;   reactome:R-HSA-1675949 "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane"


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phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inpp5d inositol polyphosphate-5-phosphatase D enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Inpp5e inositol polyphosphate-5-phosphatase E enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 3:9,216,776...9,229,539
Ensembl chr 3:9,216,776...9,229,450 		JBrowse link
G Inpp5j inositol polyphosphate-5-phosphatase J enables IEA
ISO
IBA		 GO_REF:0000107
(PMID:16280363)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:16280363 GO_REF:0000033 GO_REF:0000107 NCBI chr14:78,374,161...78,385,305
Ensembl chr14:78,374,161...78,385,326 		JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K enables ISO
IBA		 (PMID:21712384)
(PMID:21938401)
GO_REF:0000033		 RGD
GO_Central		 PMID:21712384 PMID:21938401 GO_REF:0000033 NCBI chr10:60,474,262...60,495,813
Ensembl chr10:60,475,897...60,496,773 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500 		JBrowse link
G Ocrl OCRL, inositol polyphosphate-5-phosphatase enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr  X:127,089,508...127,140,362
Ensembl chr  X:127,089,590...127,140,362 		JBrowse link
G Ptprq protein tyrosine phosphatase, receptor type, Q enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 7:42,834,455...43,016,807
Ensembl chr 7:42,837,109...43,016,917 		JBrowse link
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  molecular_function 20634
    catalytic activity 6032
      hydrolase activity 2585
        hydrolase activity, acting on ester bonds 814
          phosphoric ester hydrolase activity 371
            phosphatase activity 281
              phosphatidylinositol phosphate phosphatase activity 29
                phosphatidylinositol phosphate 5-phosphatase activity 14
                  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity 7
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