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ONTOLOGY REPORT - ANNOTATIONS

Term:Smc5-Smc6 complex
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Accession:GO:0030915 term browser browse the term
Definition:A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans.

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Smc5-Smc6 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eid3 EP300 interacting inhibitor of differentiation 3 part_of IEA TreeGrafter
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004624750:4,478,753...4,482,276
Ensembl chrNW_004624750:4,478,911...4,479,872 		JBrowse link
G Nsmce1 NSE1 homolog, SMC5-SMC6 complex component part_of ISO (PMID:26919979)
(PMID:18086888)		 MGI
UniProt		 PMID:18086888 PMID:26919979 NCBI chrNW_004624782:11,910,749...11,944,323
Ensembl chrNW_004624782:11,910,927...11,944,234 		JBrowse link
G Nsmce2 NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase part_of IEA TreeGrafter
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624735:29,915,007...30,166,564
Ensembl chrNW_004624735:29,913,423...30,151,922 		JBrowse link
G Nsmce3 NSE3 homolog, SMC5-SMC6 complex component part_of ISO (PMID:18086888), (PMID:27427983) UniProt PMID:18086888 PMID:27427983 NCBI chrNW_004624768:2,402,456...2,403,944 JBrowse link
G Nsmce4a NSE4 homolog A, SMC5-SMC6 complex component part_of IEA TreeGrafter
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004624737:24,706,292...24,724,616
Ensembl chrNW_004624737:24,706,321...24,725,351 		JBrowse link
G Smc5 structural maintenance of chromosomes 5 part_of IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624736:2,697,764...2,803,501
Ensembl chrNW_004624736:2,700,161...2,803,439 		JBrowse link
G Smc6 structural maintenance of chromosomes 6 part_of IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624738:612,758...689,191
Ensembl chrNW_004624738:614,402...681,430 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 15672
    protein-containing complex 5315
      catalytic complex 1615
        transferase complex 799
          SUMO ligase complex 11
            Smc5-Smc6 complex 7
Path 2
Term Annotations click to browse term
  cellular_component 15672
    cellular anatomical entity 15567
      organelle 11314
        non-membrane-bounded organelle 4226
          intracellular non-membrane-bounded organelle 4224
            chromosome 1193
              condensed chromosome 246
                Smc5-Smc6 complex 7
paths to the root