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ONTOLOGY REPORT - ANNOTATIONS

Term:siRNA processing
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Accession:GO:0030422 term browser browse the term
Definition:A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase.
Synonyms:exact_synonym: RNA interference, production of guide RNAs;   RNA interference, production of siRNA;   chromatin silencing by small RNA, production of guide RNAs;   chromatin silencing by small RNA, production of siRNA;   production of guide RNAs involved in RNA interference;   production of guide RNAs involved in chromatin silencing by small RNA;   production of siRNA involved in RNA interference;   production of siRNA involved in chromatin silencing by small RNA;   production of siRNA involved in post-transcriptional gene silencing by RNA
 narrow_synonym: production of siRNA involved in gene silencing by small RNA
 related_synonym: production of siRNA;   production of siRNA involved in PTGS
 alt_id: GO:0070919
 xref: Reactome:R-HSA-426486 "Small interfering RNA (siRNA) biogenesis"


show annotations for term's descendants           Sort by:
siRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago2 argonaute RISC catalytic subunit 2 involved_in ISO ComplexPortal
GO_Central		 GO_REF:0000114 GO_REF:0000119 NCBI chr15:72,967,693...73,056,777
Ensembl chr15:72,967,693...73,056,784 		JBrowse link
G Dicer1 dicer 1, ribonuclease type III acts_upstream_of_or_within
involved_in		 IDA
IBA
ISS
IMP
ISO		 (PMID:14528307)
(PMID:24209619)		 MGI
GO_Central
UniProt
ComplexPortal		 PMID:14528307 PMID:24209619 GO_REF:0000024 GO_REF:0000033 GO_REF:0000114 GO_REF:0000119 NCBI chr12:104,654,001...104,718,331
Ensembl chr12:104,654,001...104,718,211 		JBrowse link
G Henmt1 HEN1 methyltransferase homolog 1 (Arabidopsis) involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:108,846,770...108,887,201
Ensembl chr 3:108,847,375...108,868,090 		JBrowse link
G Prkra protein kinase, interferon inducible double stranded RNA dependent activator involved_in ISO
ISS
IBA		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr 2:76,436,385...76,478,614
Ensembl chr 2:76,460,242...76,478,359 		JBrowse link
G Tarbp2 TARBP2, RISC loading complex RNA binding subunit involved_in ISO
IBA
ISS		 ComplexPortal
GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000114 GO_REF:0000119 NCBI chr15:102,423,327...102,432,112
Ensembl chr15:102,426,627...102,432,111 		JBrowse link
G Tert telomerase reverse transcriptase involved_in ISO
ISS		 GO_Central
ComplexPortal		 GO_REF:0000114 GO_REF:0000119 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
G Tsn translin involved_in ISO ComplexPortal
GO_Central		 GO_REF:0000114 GO_REF:0000119 NCBI chr 1:118,226,244...118,239,463
Ensembl chr 1:118,222,508...118,239,469 		JBrowse link
G Tsnax translin-associated factor X involved_in ISO GO_Central
ComplexPortal		 GO_REF:0000114 GO_REF:0000119 NCBI chr 8:125,739,780...125,760,947
Ensembl chr 8:125,739,736...125,760,931 		JBrowse link
regulation of siRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tarbp2 TARBP2, RISC loading complex RNA binding subunit involved_in IEA InterPro GO_REF:0000002 NCBI chr15:102,423,327...102,432,112
Ensembl chr15:102,426,627...102,432,111 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28635
    cellular process 18392
      metabolic process 11624
        primary metabolic process 10232
          RNA processing 955
            regulatory ncRNA processing 69
              siRNA processing 8
                lsiRNA processing 0
                negative regulation of siRNA processing 0
                positive regulation of siRNA processing 0
                regulation of siRNA processing + 1
                ta-siRNA processing 0
Path 2
Term Annotations click to browse term
  biological_process 28635
    biological regulation 13450
      regulation of biological process 13009
        regulation of cellular process 12632
          regulation of metabolic process 6975
            regulation of biosynthetic process 5711
              regulation of macromolecule biosynthetic process 5492
                regulation of gene expression 5373
                  negative regulation of gene expression 1530
                    regulatory ncRNA-mediated gene silencing 406
                      regulatory ncRNA processing 69
                        siRNA processing 8
                          lsiRNA processing 0
                          negative regulation of siRNA processing 0
                          positive regulation of siRNA processing 0
                          regulation of siRNA processing + 1
                          ta-siRNA processing 0
paths to the root