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ONTOLOGY REPORT - ANNOTATIONS

Term:single-strand selective uracil DNA N-glycosylase activity
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Accession:GO:0017065 term browser browse the term
Definition:Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA.
Synonyms:exact_synonym: single-strand selective monofunctional uracil-DNA glycosylase activity
 xref: reactome:R-HSA-110221 "Cleavage of uracil by SMUG1 glycosylase"

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single-strand selective uracil DNA N-glycosylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G N Smug1 single-strand-selective monofunctional uracil-DNA glycosylase 1 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624904:2,185,959...2,232,541
Ensembl chrNW_004624904:2,223,600...2,231,642 		JBrowse link
G G SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr11:50,292,780...50,307,828
Ensembl chr11:50,289,154...50,300,492 		JBrowse link
G P SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 5:19,375,244...19,412,656
Ensembl chr 5:19,398,252...19,412,648 		JBrowse link
G S Smug1 single-strand-selective monofunctional uracil-DNA glycosylase 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936512:11,395,513...11,416,426
Ensembl chrNW_004936512:11,395,834...11,402,377 		JBrowse link
G D SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 enables IEA InterPro GO_REF:0000002 NCBI chr27:1,086,675...1,093,175
Ensembl chr27:1,089,808...1,111,129 		JBrowse link
G B SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr12:34,564,624...34,572,063
Ensembl chr12:35,288,412...35,296,670 		JBrowse link
G C Smug1 single-strand-selective monofunctional uracil-DNA glycosylase 1 enables ISO (PMID:12161446), (PMID:12718543) HGNC-UCL PMID:12161446 PMID:12718543 RGD:634191 NCBI chrNW_004955458:1,432,988...1,449,019
Ensembl chrNW_004955458:1,431,721...1,447,292 		JBrowse link
G R Smug1 single-strand-selective monofunctional uracil-DNA glycosylase 1 enables ISO
IDA		 (PMID:12161446), (PMID:12718543) RGD PMID:12161446 PMID:12718543 PMID:12718543 RGD:634191 NCBI chr 7:134,288,565...134,302,179
Ensembl chr 7:134,287,675...134,297,226 		JBrowse link
G M Smug1 single-strand selective monofunctional uracil DNA glycosylase enables ISO
ISS		 (MGI:2661291|PMID:12718543) MGI
HGNC-UCL		 PMID:12718543 GO_REF:0000096 GO_REF:0000119 MGI:2661291 MGI:4417868 MGI:4834177 NCBI chr15:103,061,717...103,077,360
Ensembl chr15:103,061,717...103,075,519 		JBrowse link
G H SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 enables IEA
TAS
IDA		 (PMID:12161446), (PMID:12718543) Ensembl
Reactome
HGNC-UCL
InterPro		 PMID:12161446 PMID:12718543 GO_REF:0000002 GO_REF:0000107 Reactome:R-HSA-110221 NCBI chr12:54,158,235...54,188,985
Ensembl chr12:54,121,277...54,189,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 189906
    catalytic activity 54002
      catalytic activity, acting on a nucleic acid 5830
        catalytic activity, acting on DNA 2367
          DNA N-glycosylase activity 134
            deaminated base DNA N-glycosylase activity 32
              uracil DNA N-glycosylase activity 32
                single-strand selective uracil DNA N-glycosylase activity 10
Path 2
Term Annotations click to browse term
  molecular_function 189906
    catalytic activity 54002
      hydrolase activity 22736
        hydrolase activity, acting on glycosyl bonds 1257
          hydrolase activity, hydrolyzing N-glycosyl compounds 298
            DNA N-glycosylase activity 134
              deaminated base DNA N-glycosylase activity 32
                uracil DNA N-glycosylase activity 32
                  single-strand selective uracil DNA N-glycosylase activity 10
paths to the root