Smug1 (single-strand-selective monofunctional uracil-DNA glycosylase 1) - Rat Genome Database

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Gene: Smug1 (single-strand-selective monofunctional uracil-DNA glycosylase 1) Ictidomys tridecemlineatus
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Symbol: Smug1
Name: single-strand-selective monofunctional uracil-DNA glycosylase 1
RGD ID: 12507827
Description: ENCODES a protein that exhibits identical protein binding (ortholog); oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity (ortholog); uracil DNA N-glycosylase activity (ortholog); INVOLVED IN DNA repair (ortholog); ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); prostate cancer (ortholog); FOUND IN cytosol (inferred); fibrillar center (inferred); nucleolus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: single-strand selective monofunctional uracil DNA glycosylase; single-strand-selective monofunctional uracil-DNA glycosylase 1, transcript variant X1; single-strand-selective monofunctional uracil-DNA glycosylase 1, transcript variant X10; single-strand-selective monofunctional uracil-DNA glycosylase 1, transcript variant X11; single-strand-selective monofunctional uracil-DNA glycosylase 1, transcript variant X12; single-strand-selective monofunctional uracil-DNA glycosylase 1, transcript variant X5; single-strand-selective monofunctional uracil-DNA glycosylase 1, transcript variant X6; single-strand-selective monofunctional uracil-DNA glycosylase 1, transcript variant X7; single-strand-selective monofunctional uracil-DNA glycosylase 1, transcript variant X8; single-strand-selective monofunctional uracil-DNA glycosylase 1, transcript variant X9
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494561,762,394 - 61,796,876 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651211,395,834 - 11,402,377 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651211,395,513 - 11,416,426 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
fibrillar center  (IEA)
nucleolus  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Smug1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494561,762,394 - 61,796,876 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651211,395,834 - 11,402,377 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651211,395,513 - 11,416,426 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMUG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381254,158,235 - 54,188,985 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1254,121,277 - 54,189,008 (-)EnsemblGRCh38hg38GRCh38
GRCh371254,574,150 - 54,582,769 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361252,861,519 - 52,869,024 (-)NCBINCBI36Build 36hg18NCBI36
Celera1254,226,170 - 54,233,675 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1251,611,811 - 51,620,446 (-)NCBIHuRef
CHM1_11254,540,762 - 54,549,526 (-)NCBICHM1_1
T2T-CHM13v2.01254,119,277 - 54,154,492 (-)NCBIT2T-CHM13v2.0
Smug1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915103,061,717 - 103,077,360 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15103,061,717 - 103,075,519 (-)EnsemblGRCm39 Ensembl
GRCm3815103,153,290 - 103,168,939 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15103,153,290 - 103,167,092 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715102,983,721 - 102,993,715 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615102,981,324 - 102,991,318 (-)NCBIMGSCv36mm8
Celera15105,314,542 - 105,324,536 (-)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1558.2NCBI
Smug1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87136,166,157 - 136,177,673 (-)NCBIGRCr8
mRatBN7.27134,288,565 - 134,302,179 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7134,287,675 - 134,297,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7136,045,289 - 136,047,414 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07138,274,666 - 138,276,791 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07138,260,724 - 138,262,849 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,774,155 - 144,788,333 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,774,160 - 144,778,656 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07142,560,270 - 142,569,924 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47142,064,428 - 142,066,553 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17142,144,616 - 142,151,752 (-)NCBI
Celera7130,715,767 - 130,717,892 (-)NCBICelera
Cytogenetic Map7q36NCBI
Smug1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554581,431,721 - 1,447,292 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554581,432,988 - 1,449,019 (-)NCBIChiLan1.0ChiLan1.0
SMUG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21039,991,866 - 39,999,340 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11239,988,635 - 39,996,093 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01234,564,624 - 34,572,063 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11235,288,412 - 35,296,670 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1235,288,412 - 35,296,670 (+)Ensemblpanpan1.1panPan2
SMUG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,086,675 - 1,093,175 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,089,808 - 1,111,129 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2745,157,542 - 45,164,017 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0271,088,178 - 1,094,647 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,088,357 - 1,235,362 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1271,107,011 - 1,113,490 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,088,345 - 1,094,825 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02745,561,546 - 45,568,018 (-)NCBIUU_Cfam_GSD_1.0
SMUG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl519,398,252 - 19,412,648 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1519,375,244 - 19,412,656 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2520,035,790 - 20,050,156 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMUG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11150,292,780 - 50,307,828 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1150,289,154 - 50,300,492 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037195,741,787 - 195,751,095 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smug1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249042,223,600 - 2,231,642 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249042,185,959 - 2,232,541 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005325071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021726221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021726222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021726223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021726224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021726225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021726227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021726228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021726229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040280527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040280528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040280529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002483941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002483942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002483943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSSTOT00000004538   ⟹   ENSSTOP00000004071
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493651211,395,834 - 11,402,377 (-)Ensembl
RefSeq Acc Id: XM_005325071   ⟹   XP_005325128
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494561,762,395 - 61,768,369 (+)NCBI
SpeTri2.0NW_00493651211,395,834 - 11,402,409 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021726221   ⟹   XP_021581896
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494561,764,286 - 61,768,369 (+)NCBI
SpeTri2.0NW_00493651211,395,834 - 11,399,165 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040280527   ⟹   XP_040136461
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494561,762,527 - 61,768,369 (+)NCBI
RefSeq Acc Id: XM_040280528   ⟹   XP_040136462
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494561,764,281 - 61,796,876 (+)NCBI
RefSeq Acc Id: XM_040280529   ⟹   XP_040136463
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494561,762,394 - 61,768,369 (+)NCBI
RefSeq Acc Id: XR_002483941
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494561,764,286 - 61,769,317 (+)NCBI
SpeTri2.0NW_00493651211,395,802 - 11,399,165 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005325128   ⟸   XM_005325071
- Peptide Label: isoform X2
- UniProtKB: I3M4F6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021581896   ⟸   XM_021726221
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_040136463   ⟸   XM_040280529
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040136461   ⟸   XM_040280527
- Peptide Label: isoform X2
- UniProtKB: I3M4F6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040136462   ⟸   XM_040280528
- Peptide Label: isoform X3
RefSeq Acc Id: ENSSTOP00000004071   ⟸   ENSSTOT00000004538
Protein Domains
Uracil-DNA glycosylase-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000004542 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000004538.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.470.10 UniProtKB/TrEMBL
InterPro SMUG1 UniProtKB/TrEMBL
  Uracil-DNA_glycosylase-like UniProtKB/TrEMBL
  Uracil-DNA_glycosylase-like_sf UniProtKB/TrEMBL
NCBI Gene Smug1 ENTREZGENE
PANTHER PTHR13235 UniProtKB/TrEMBL
  SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE UniProtKB/TrEMBL
Pfam UDG UniProtKB/TrEMBL
Superfamily-SCOP SSF52141 UniProtKB/TrEMBL
UniProt I3M4F6 ENTREZGENE, UniProtKB/TrEMBL