Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of tumor necrosis factor-mediated signaling pathway
go back to main search page
Accession:GO:0010803 term browser browse the term
Definition:Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
Synonyms:exact_synonym: regulation of TNF signaling;   regulation of TNF-mediated signaling pathway;   regulation of tumor necrosis factor-mediated signalling pathway

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase involved_in ISO (MGI:5912943|PMID:28701375)
(PMID:26997266), (PMID:27458237), (PMID:27591049)		 UniProt PMID:26997266 PMID:27458237 PMID:27591049 PMID:28701375 MGI:5912943 NCBI chrNW_004624757:5,895,912...5,953,485 JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (PMID:29415886) MGI PMID:29415886 NCBI chrNW_004624763:16,126,582...16,393,476
Ensembl chrNW_004624763:16,126,938...16,392,804 		JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 involved_in ISO (PMID:15701637) UniProt PMID:15701637 NCBI chrNW_004624772:9,579,488...9,658,881 JBrowse link
G Nkiras1 NFKB inhibitor interacting Ras like 1 acts_upstream_of_or_within ISO (PMID:25220458) MGI PMID:25220458 NCBI chrNW_004624788:1,590,441...1,639,059
Ensembl chrNW_004624788:1,608,247...1,639,083 		JBrowse link
G Nkiras2 NFKB inhibitor interacting Ras like 2 acts_upstream_of_or_within ISO (PMID:25220458) MGI PMID:25220458 NCBI chrNW_004624795:1,828,046...1,830,880
Ensembl chrNW_004624795:1,828,046...1,830,483 		JBrowse link
G Otulin OTU deubiquitinase with linear linkage specificity involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624751:11,676,932...11,703,143
Ensembl chrNW_004624751:11,676,850...11,702,061 		JBrowse link
G Pias3 protein inhibitor of activated STAT 3 acts_upstream_of_or_within ISO (PMID:17442941) MGI PMID:17442941 NCBI chrNW_004624772:17,217,068...17,226,757
Ensembl chrNW_004624772:17,217,986...17,224,020 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:14730312) UniProt PMID:14730312 NCBI chrNW_004624782:14,247,333...14,249,861
Ensembl chrNW_004624782:14,247,864...14,249,000 		JBrowse link
G Sharpin SHANK associated RH domain interactor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624735:12,719,196...12,723,578
Ensembl chrNW_004624735:12,719,762...12,723,348 		JBrowse link
G Spata2 spermatogenesis associated 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624790:5,553,082...5,572,250 JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO (PMID:20577214)
PMID:28284343		 UniProt PMID:20577214 PMID:28284343 RGD:14397556 NCBI chrNW_004624801:6,253,219...6,257,128 JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISO (PMID:19151749) CACAO PMID:19151749 NCBI chrNW_004624868:1,654,079...1,738,648
Ensembl chrNW_004624868:1,653,997...1,701,391 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A acts_upstream_of_or_within ISO (PMID:25220458) MGI PMID:25220458 NCBI chrNW_004624860:3,111,244...3,123,041
Ensembl chrNW_004624860:3,111,630...3,122,711 		JBrowse link
negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624730:69,941,963...69,959,266
Ensembl chrNW_004624730:69,941,001...69,957,012 		JBrowse link
G Apoa1 apolipoprotein A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624784:12,249,283...12,251,215
Ensembl chrNW_004624784:12,249,283...12,251,136 		JBrowse link
G Birc7 baculoviral IAP repeat containing 7 involved_in ISO (PMID:11865055) UniProt PMID:11865055 NCBI chrNW_004624741:28,937,836...28,944,000 JBrowse link
G Ccdc3 coiled-coil domain containing 3 involved_in ISO (PMID:25193116) UniProt PMID:25193116 NCBI chrNW_004624805:5,465,699...5,574,837
Ensembl chrNW_004624805:5,465,001...5,574,291 		JBrowse link
G Cldn18 claudin 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22437732) Ensembl
MGI		 PMID:22437732 GO_REF:0000107 NCBI chrNW_004624730:14,500,379...14,522,047
Ensembl chrNW_004624730:14,489,585...14,522,042 		JBrowse link
G Dicer1 dicer 1, ribonuclease III involved_in
acts_upstream_of		 IEA
ISO		 (PMID:26435691) Ensembl
ARUK-UCL		 PMID:26435691 GO_REF:0000107 NCBI chrNW_004624734:7,604,049...7,681,481
Ensembl chrNW_004624734:7,608,273...7,651,819 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:19781631) UniProt PMID:19781631 NCBI chrNW_004624869:1,326,605...1,337,195 JBrowse link
G Gas6 growth arrest specific 6 involved_in ISO (PMID:19657094) UniProt PMID:19657094 NCBI chrNW_004624793:385,846...410,934
Ensembl chrNW_004624793:385,812...410,934 		JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (MGI:6148454|PMID:22424771) UniProt PMID:22424771 MGI:6148454 NCBI chrNW_004624786:9,938,384...9,941,210
Ensembl chrNW_004624786:9,938,384...9,941,235 		JBrowse link
G LOC101720625 heat shock factor protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624746:19,141,861...19,151,392
Ensembl chrNW_004624746:19,146,210...19,151,061 		JBrowse link
G Naip NLR family apoptosis inhibitory protein involved_in ISO (PMID:11865055) UniProt PMID:11865055 NCBI chrNW_004624905:437,799...485,774 JBrowse link
G Nr1h4 nuclear receptor subfamily 1 group H member 4 involved_in ISO (MGI:5707586|PMID:18972444) UniProt PMID:18972444 MGI:5707586 NCBI chrNW_004624750:7,222,306...7,303,809
Ensembl chrNW_004624750:7,219,251...7,303,834 		JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO (PMID:23950925)
(PMID:24113711)		 MGI PMID:23950925 PMID:24113711 NCBI chrNW_004624767:19,920,149...19,938,892
Ensembl chrNW_004624767:19,920,687...19,929,638 		JBrowse link
G Pias4 protein inhibitor of activated STAT 4 acts_upstream_of_or_within ISO (PMID:20054338) MGI PMID:20054338 NCBI chrNW_004624828:5,551,538...5,572,647
Ensembl chrNW_004624828:5,551,749...5,572,570 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta acts_upstream_of ISO (PMID:28159925) ARUK-UCL PMID:28159925 NCBI chrNW_004624780:13,332,636...13,369,301 JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (MGI:3530208|PMID:15696169) UniProt PMID:15696169 MGI:3530208 NCBI chrNW_004624770:19,808,400...19,877,494
Ensembl chrNW_004624770:19,808,400...19,876,503 		JBrowse link
G Rffl ring finger and FYVE like domain containing E3 ubiquitin protein ligase involved_in ISO (PMID:18450452) UniProt PMID:18450452 NCBI chrNW_004624875:2,896,888...2,964,838
Ensembl chrNW_004624875:2,897,832...2,964,866 		JBrowse link
G Tank TRAF family member associated NFKB activator involved_in ISO (PMID:8710854) MGI PMID:8710854 NCBI chrNW_004624732:4,221,294...4,325,199
Ensembl chrNW_004624732:4,220,963...4,300,861 		JBrowse link
G Tjp2 tight junction protein 2 acts_upstream_of_or_within ISO (PMID:22437732) MGI PMID:22437732 NCBI chrNW_004624736:3,833,402...4,009,385
Ensembl chrNW_004624736:3,834,548...3,878,828 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11b acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:29415886) MGI
Ensembl		 PMID:29415886 GO_REF:0000107 NCBI chrNW_004624763:17,139,109...17,166,398
Ensembl chrNW_004624763:17,138,847...17,166,453 		JBrowse link
G Traip TRAF interacting protein involved_in ISO (PMID:19151749) CACAO PMID:19151749 NCBI chrNW_004624730:3,749,183...3,775,062
Ensembl chrNW_004624730:3,748,894...3,774,489 		JBrowse link
positive regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 involved_in ISO (PMID:24813629) BHF-UCL PMID:24813629 NCBI chrNW_004624969:212,089...254,532
Ensembl chrNW_004624969:212,321...253,328 		JBrowse link
G Casp4 caspase 4 involved_in ISO (PMID:16920334) UniProt PMID:16920334 NCBI chrNW_004624918:145,661...187,006 JBrowse link
G Cpne1 copine 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624842:3,787,275...3,823,635
Ensembl chrNW_004624842:3,808,069...3,822,734 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:6391873|PMID:22733818) ARUK-UCL PMID:22733818 MGI:6391873 NCBI chrNW_004624764:14,208,144...14,277,208
Ensembl chrNW_004624764:14,207,094...14,228,135 		JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624878:124,396...174,584
Ensembl chrNW_004624878:164,171...175,654 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO (PMID:23453807) ParkinsonsUK-UCL PMID:23453807 NCBI chrNW_004624855:430,148...1,992,121
Ensembl chrNW_004624855:430,260...1,989,747 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624756:21,806,570...21,837,351
Ensembl chrNW_004624756:21,805,599...21,830,699 		JBrowse link
G Traf2 TNF receptor associated factor 2 involved_in ISO (MGI:5616328|PMID:11374864) AgBase PMID:11374864 MGI:5616328 NCBI chrNW_004624760:952,574...973,511
Ensembl chrNW_004624760:952,574...965,661 		JBrowse link
G Trim32 tripartite motif containing 32 acts_upstream_of_or_within ISO (PMID:20054338) MGI PMID:20054338 NCBI chrNW_004624760:18,577,764...18,600,869
Ensembl chrNW_004624760:18,585,279...18,599,659 		JBrowse link
G Ube2k ubiquitin conjugating enzyme E2 K involved_in ISO (PMID:26707646) FlyBase PMID:26707646 NCBI chrNW_004624761:27,205,034...27,277,016
Ensembl chrNW_004624761:27,205,034...27,276,884 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    regulation of biological process 10301
      regulation of response to stimulus 3638
        regulation of response to cytokine stimulus 145
          regulation of cytokine-mediated signaling pathway 134
            regulation of tumor necrosis factor-mediated signaling pathway 44
              negative regulation of tumor necrosis factor-mediated signaling pathway 21
              positive regulation of tumor necrosis factor-mediated signaling pathway 10
Path 2
Term Annotations click to browse term
  biological_process 15093
    response to stimulus 8161
      response to chemical 4389
        response to peptide 990
          response to cytokine 967
            cellular response to cytokine stimulus 846
              cellular response to tumor necrosis factor 224
                tumor necrosis factor-mediated signaling pathway 90
                  regulation of tumor necrosis factor-mediated signaling pathway 44
                    negative regulation of tumor necrosis factor-mediated signaling pathway 21
                    positive regulation of tumor necrosis factor-mediated signaling pathway 10
paths to the root