Rffl (ring finger and FYVE like domain containing E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: Rffl (ring finger and FYVE like domain containing E3 ubiquitin protein ligase) Heterocephalus glaber
Analyze
Symbol: Rffl
Name: ring finger and FYVE like domain containing E3 ubiquitin protein ligase
RGD ID: 18910420
Description: ENCODES a protein that exhibits p53 binding (ortholog); protease binding (ortholog); protein kinase binding (ortholog); INVOLVED IN intracellular protein transport (ortholog); negative regulation of signal transduction by p53 class mediator (ortholog); negative regulation of tumor necrosis factor-mediated signaling pathway (ortholog); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH genetic disease (ortholog); hypertension (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytoplasmic vesicle (ortholog); endosome membrane (ortholog); Golgi membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase rififylin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248752,897,832 - 2,964,866 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248752,896,888 - 2,964,838 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Rffl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248752,897,832 - 2,964,866 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248752,896,888 - 2,964,838 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RFFL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,005,990 - 35,089,226 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,005,990 - 35,089,319 (-)EnsemblGRCh38hg38GRCh38
GRCh371733,333,009 - 33,416,245 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361730,360,244 - 30,440,407 (-)NCBINCBI36Build 36hg18NCBI36
Celera1730,246,327 - 30,326,489 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1729,522,054 - 29,601,016 (-)NCBIHuRef
CHM1_11733,400,524 - 33,480,727 (-)NCBICHM1_1
T2T-CHM13v2.01735,953,906 - 36,037,140 (-)NCBIT2T-CHM13v2.0
Rffl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,694,645 - 82,762,065 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,693,275 - 82,762,036 (-)EnsemblGRCm39 Ensembl
GRCm381182,803,819 - 82,871,236 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,802,449 - 82,871,210 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,617,321 - 82,684,712 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,620,017 - 82,686,939 (-)NCBIMGSCv36mm8
Celera1192,423,191 - 92,490,746 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.25NCBI
Rffl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,238,273 - 68,301,225 (-)NCBIGRCr8
mRatBN7.21067,740,711 - 67,803,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,740,712 - 67,824,434 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,360,780 - 72,423,716 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,866,156 - 71,929,095 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,327,967 - 67,393,247 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,157,621 - 70,220,618 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,157,621 - 70,220,582 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,788,330 - 69,851,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,025,035 - 71,047,280 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,038,657 - 71,060,903 (-)NCBI
Celera1066,686,813 - 66,709,204 (-)NCBICelera
Cytogenetic Map10q26NCBI
Rffl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554819,718,369 - 9,765,132 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554819,718,369 - 9,788,048 (-)NCBIChiLan1.0ChiLan1.0
RFFL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21929,376,768 - 29,456,993 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11731,312,229 - 31,337,987 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01721,696,808 - 21,779,878 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11722,014,167 - 22,069,553 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,035,643 - 22,069,546 (+)Ensemblpanpan1.1panPan2
RFFL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,271,419 - 38,346,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl938,222,051 - 38,365,621 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,495,000 - 37,573,581 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,083,074 - 39,162,504 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl939,054,329 - 39,156,002 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,866,520 - 37,945,113 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,151,818 - 38,231,027 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,239,649 - 38,318,516 (+)NCBIUU_Cfam_GSD_1.0
Rffl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560237,282,719 - 37,325,679 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936538139,723 - 203,600 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936538139,690 - 203,600 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RFFL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,075,337 - 40,151,043 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,075,259 - 40,151,034 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,676,668 - 41,712,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RFFL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11628,515,393 - 28,593,289 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1628,518,231 - 28,533,070 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660751,388,544 - 1,472,758 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000002330   ⟹   ENSHGLP00000002281
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248752,897,832 - 2,964,866 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000002331   ⟹   ENSHGLP00000002282
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248752,899,295 - 2,942,299 (-)Ensembl
RefSeq Acc Id: XM_004870622   ⟹   XP_004870679
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248752,896,888 - 2,942,346 (-)NCBI
RefSeq Acc Id: XM_021248924   ⟹   XP_021104583
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248752,897,315 - 2,964,838 (-)NCBI
RefSeq Acc Id: XM_021248925   ⟹   XP_021104584
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248752,897,315 - 2,964,838 (-)NCBI
RefSeq Acc Id: XM_021248926   ⟹   XP_021104585
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248752,897,315 - 2,915,598 (-)NCBI
RefSeq Acc Id: XM_021248927   ⟹   XP_021104586
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248752,897,315 - 2,964,838 (-)NCBI
RefSeq Acc Id: XM_021248928   ⟹   XP_021104587
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248752,896,888 - 2,942,346 (-)NCBI
RefSeq Acc Id: XM_021248929   ⟹   XP_021104588
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248752,896,888 - 2,942,346 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021104588   ⟸   XM_021248929
- Peptide Label: isoform X7
RefSeq Acc Id: XP_004870679   ⟸   XM_004870622
- Peptide Label: isoform X6
- UniProtKB: A0A0P6J032 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021104587   ⟸   XM_021248928
- Peptide Label: isoform X5
- UniProtKB: A0A0P6J032 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021104586   ⟸   XM_021248927
- Peptide Label: isoform X4
- UniProtKB: A0A0P6J032 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021104584   ⟸   XM_021248925
- Peptide Label: isoform X2
- UniProtKB: A0A0P6J032 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021104583   ⟸   XM_021248924
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J032 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021104585   ⟸   XM_021248926
- Peptide Label: isoform X3
- UniProtKB: A0A0P6J032 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000002281   ⟸   ENSHGLT00000002330
RefSeq Acc Id: ENSHGLP00000002282   ⟸   ENSHGLT00000002331


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001734 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000002330 ENTREZGENE
  ENSHGLT00000002331 ENTREZGENE
Gene3D-CATH 1.10.720.140 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro CARP1_2_FYVE UniProtKB/TrEMBL
  CARP2_FYVE UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene Rffl ENTREZGENE
PANTHER CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE RIFIFYLIN UniProtKB/TrEMBL
Pfam FYVE_CARP1-2 UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
PROSITE ZF_RING_2 UniProtKB/TrEMBL
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
  SSF68906 UniProtKB/TrEMBL
UniProt A0A0P6J032 ENTREZGENE, UniProtKB/TrEMBL