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ONTOLOGY REPORT - ANNOTATIONS

Term:glutamate decarboxylation to succinate
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Accession:GO:0006540 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes.
Comment:Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively).
Synonyms:exact_synonym: 4-aminobutyrate shunt;   GABA shunt;   degradation of glutamate to succinate through GABA;   gamma-aminobutyrate shunt;   glutamate degradation via 4-aminobutyrate;   glutamate degradation via GABA
 xref: MetaCyc:GLUDEG-I-PWY


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glutamate decarboxylation to succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gad2 glutamate decarboxylase 2 involved_in IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:8999827 GO_REF:0000033, RGD:1625237 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
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Term Annotations click to browse term
  biological_process 19692
    metabolic process 11456
      cellular metabolic process 9554
        organic acid metabolic process 1021
          oxoacid metabolic process 1010
            carboxylic acid metabolic process 995
              dicarboxylic acid metabolic process 101
                succinate metabolic process 8
                  glutamate decarboxylation to succinate 1
                    glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity 0
                    glutamate catabolic process to succinate via succinate semialdehyde 0
Path 2
Term Annotations click to browse term
  biological_process 19692
    cellular process 18195
      cellular metabolic process 9554
        organic acid metabolic process 1021
          oxoacid metabolic process 1010
            carboxylic acid metabolic process 995
              alpha-amino acid metabolic process 210
                L-amino acid metabolic process 177
                  glutamine family amino acid metabolic process 75
                    glutamate metabolic process 37
                      glutamate catabolic process 6
                        glutamate decarboxylation to succinate 1
                          glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity 0
                          glutamate catabolic process to succinate via succinate semialdehyde 0
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