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Ontology Browser

Term:
glutamate decarboxylation to succinate (GO:0006540)
Annotations: Rat: (1) Mouse: (1) Human: (2) Chinchilla: (1) Bonobo: (1) Dog: (1) Squirrel: (1) Pig: (1)
Parent Terms Term With Siblings Child Terms
glutamate catabolic process to 2-oxoglutarate  
glutamate catabolic process to 4-hydroxybutyrate 
glutamate catabolic process to aspartate  
glutamate catabolic process to butyrate 
glutamate catabolic process to ornithine 
glutamate catabolic process to oxaloacetate 
glutamate catabolic process to propionate 
glutamate catabolic process via 2-oxoglutarate  
glutamate catabolic process via L-citramalate 
glutamate decarboxylation to succinate +   
The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes.
glutamine catabolic process to fumarate +  
glutamine catabolic process to fumarate, using glutaminase 

Synonyms
Exact Synonyms: 4-aminobutyrate shunt ;   GABA shunt ;   degradation of glutamate to succinate through GABA ;   gamma-aminobutyrate shunt ;   glutamate degradation via 4-aminobutyrate ;   glutamate degradation via GABA
Xrefs: MetaCyc:GLUDEG-I-PWY ;   MetaCyc:PWY-4321 ;   MetaCyc:PWY3O-210
Definition Sources: PMID:12740438

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