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ONTOLOGY REPORT - ANNOTATIONS

Term:anaphase-promoting complex
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Accession:GO:0005680 term browser browse the term
Definition:A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
Comment:Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.
Synonyms:exact_synonym: cyclosome
 broad_synonym: APC
 xref: Wikipedia:Anaphase-promoting_complex


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anaphase-promoting complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANAPC1 anaphase promoting complex subunit 1 located_in
part_of		 ISO
IEA
IBA		 (PMID:27120157) ComplexPortal
InterPro
Ensembl
GO_Central
TreeGrafter		 PMID:27120157 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:44,483,961...44,605,035
Ensembl chr 3:44,509,680...44,605,014 		JBrowse link
G ANAPC10 anaphase promoting complex subunit 10 located_in
part_of		 ISO
IEA
IBA		 (PMID:27120157) ComplexPortal
InterPro
Ensembl
TreeGrafter
GO_Central		 PMID:27120157 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:83,353,217...83,497,570
Ensembl chr 8:83,353,231...83,436,518 		JBrowse link
G ANAPC11 anaphase promoting complex subunit 11 located_in
part_of		 ISO
IEA		 (PMID:27120157) ComplexPortal
InterPro
TreeGrafter		 PMID:27120157 GO_REF:0000002 GO_REF:0000118 NCBI chr12:1,095,091...1,099,233 JBrowse link
G ANAPC13 anaphase promoting complex subunit 13 located_in
part_of		 ISO
IEA
IBA		 (PMID:27120157) ComplexPortal
Ensembl
InterPro
GO_Central
TreeGrafter		 PMID:27120157 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:75,599,797...75,605,667
Ensembl chr13:75,599,800...75,605,140 		JBrowse link
G ANAPC15 anaphase promoting complex subunit 15 located_in
part_of		 ISO
IEA		 (PMID:27120157) ComplexPortal
Ensembl
InterPro
TreeGrafter		 PMID:27120157 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:6,685,934...6,689,913
Ensembl chr 9:6,685,939...6,689,256 		JBrowse link
G ANAPC16 anaphase promoting complex subunit 16 located_in
part_of		 ISO
IEA		 (PMID:27120157) ComplexPortal
Ensembl
InterPro
TreeGrafter		 PMID:27120157 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr14:75,082,673...75,093,078
Ensembl chr14:75,082,740...75,093,074 		JBrowse link
G ANAPC2 anaphase promoting complex subunit 2 located_in
part_of		 ISO
IEA
IBA		 (PMID:27120157) ComplexPortal
Ensembl
TreeGrafter
GO_Central		 PMID:27120157 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118
G ANAPC4 anaphase promoting complex subunit 4 located_in
part_of		 ISO
IEA
IBA		 (PMID:27120157) ComplexPortal
Ensembl
InterPro
UniProt
GO_Central
TreeGrafter		 PMID:27120157 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:19,301,253...19,341,463
Ensembl chr 8:19,301,248...19,341,478 		JBrowse link
G ANAPC5 anaphase promoting complex subunit 5 located_in
part_of		 ISO
IEA
IBA		 (PMID:27120157) ComplexPortal
InterPro
Ensembl
GO_Central
TreeGrafter		 PMID:27120157 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr14:31,259,695...31,306,434
Ensembl chr14:31,259,727...31,306,441 		JBrowse link
G ANAPC7 anaphase promoting complex subunit 7 located_in
part_of		 ISO
IEA
IBA		 (PMID:27120157) ComplexPortal
Ensembl
GO_Central
TreeGrafter		 PMID:27120157 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr14:31,744,729...31,789,750
Ensembl chr14:31,763,243...31,789,750 		JBrowse link
G CDC16 cell division cycle 16 located_in
part_of		 ISO
IEA
IBA		 (PMID:27120157) ComplexPortal
Ensembl
TreeGrafter
GO_Central		 PMID:27120157 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr11:79,084,243...79,111,758
Ensembl chr11:79,084,182...79,115,268 		JBrowse link
G CDC20 cell division cycle 20 part_of
located_in		 IEA
ISS
IBA		 Ensembl
UniProt
GO_Central
TreeGrafter		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:167,886,266...167,890,587
Ensembl chr 6:167,886,270...167,890,583 		JBrowse link
G CDC20B cell division cycle 20B part_of IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr16:34,294,486...34,354,588
Ensembl chr16:34,294,272...34,349,242 		JBrowse link
G CDC23 cell division cycle 23 located_in
part_of		 ISO
IEA
IBA		 (PMID:27120157) ComplexPortal
InterPro
Ensembl
TreeGrafter
GO_Central		 PMID:27120157 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:140,211,334...140,245,728
Ensembl chr 2:140,211,331...140,230,789 		JBrowse link
G CDC26 cell division cycle 26 located_in
part_of		 ISO
IEA		 (PMID:27120157) ComplexPortal
Ensembl
InterPro
TreeGrafter		 PMID:27120157 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:253,893,666...253,906,659
Ensembl chr 1:253,895,885...253,906,632 		JBrowse link
G CDC27 cell division cycle 27 located_in
part_of		 ISO
IEA
IBA		 (PMID:27120157) ComplexPortal
Ensembl
GO_Central
TreeGrafter		 PMID:27120157 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr12:16,810,868...16,882,271
Ensembl chr12:16,810,910...16,882,269 		JBrowse link
G FZR1 fizzy and cell division cycle 20 related 1 part_of IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:75,122,599...75,164,134
Ensembl chr 2:75,121,835...75,146,835 		JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 part_of
located_in		 IEA
ISO		 (PMID:11459825) Ensembl
UniProt		 PMID:11459825 GO_REF:0000107 NCBI chr 6:71,773,680...71,779,192
Ensembl chr 6:71,773,682...71,779,183 		JBrowse link
G UBE2C ubiquitin conjugating enzyme E2 C part_of IEA Ensembl GO_REF:0000107 NCBI chr17:48,018,403...48,021,542
Ensembl chr17:48,018,400...48,021,534 		JBrowse link
G UBE2S ubiquitin conjugating enzyme E2 S part_of IEA Ensembl GO_REF:0000107 NCBI chr 6:59,565,001...59,570,484
Ensembl chr 6:59,565,033...59,570,489 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18686
    protein-containing complex 6005
      nuclear protein-containing complex 1244
        nuclear ubiquitin ligase complex 46
          anaphase-promoting complex 20
Path 2
Term Annotations click to browse term
  cellular_component 18686
    cellular anatomical entity 18466
      intracellular anatomical structure 13505
        intracellular organelle 12019
          intracellular membrane-bounded organelle 10861
            nucleus 6843
              nuclear protein-containing complex 1244
                nuclear ubiquitin ligase complex 46
                  anaphase-promoting complex 20
paths to the root