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ONTOLOGY REPORT - ANNOTATIONS

Term:activation of membrane attack complex
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Accession:GO:0001905 term browser browse the term
Definition:The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
Synonyms:exact_synonym: MAC assembly;   MAC formation;   activation of MAC;   membrane attack complex assembly;   membrane attack complex formation
 narrow_synonym: activation of TCC;   activation of terminal complement complex;   activation of the terminal complement cascade

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activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H acts_upstream_of_or_within ISO (PMID:20813971) MGI PMID:20813971 NCBI chrNW_004624798:3,332,549...3,414,435 JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in ISO (MGI:4430818|PMID:15611275) BHF-UCL PMID:15611275 MGI:4430818 NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946 		JBrowse link
G C6 complement C6 involved_in ISO (MGI:4430818|PMID:15611275) BHF-UCL PMID:15611275 MGI:4430818 NCBI chrNW_004624759:13,775,339...13,842,415
Ensembl chrNW_004624759:13,775,358...13,842,648 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    immune system process 2103
      immune effector process 553
        complement activation 46
          activation of membrane attack complex 3
            negative regulation of activation of membrane attack complex 0
            positive regulation of activation of membrane attack complex 2
            regulation of activation of membrane attack complex + 2
Path 2
Term Annotations click to browse term
  biological_process 15093
    biological regulation 10618
      regulation of biological process 10301
        positive regulation of biological process 5901
          positive regulation of response to stimulus 2172
            positive regulation of immune response 617
              activation of immune response 460
                complement activation 46
                  activation of membrane attack complex 3
                    negative regulation of activation of membrane attack complex 0
                    positive regulation of activation of membrane attack complex 2
                    regulation of activation of membrane attack complex + 2
paths to the root