C6 (complement C6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: C6 (complement C6) Heterocephalus glaber
Analyze
Symbol: C6
Name: complement C6
RGD ID: 18915629
Description: INVOLVED IN in utero embryonic development (ortholog); positive regulation of activation of membrane attack complex (ortholog); positive regulation of angiogenesis (ortholog); ASSOCIATED WITH Alcoholic Liver Diseases (ortholog); C6 Deficiency, Subtotal (ortholog); calcinosis (ortholog); FOUND IN extracellular space (ortholog); membrane attack complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Complement component C6
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475913,775,358 - 13,842,648 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475913,775,339 - 13,842,415 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:21993625   PMID:22301074  


Genomics

Comparative Map Data
C6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475913,775,358 - 13,842,648 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475913,775,339 - 13,842,415 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
C6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38541,142,116 - 41,261,469 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl541,142,116 - 41,261,438 (-)EnsemblGRCh38hg38GRCh38
GRCh37541,142,218 - 41,261,571 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36541,178,093 - 41,249,369 (-)NCBINCBI36Build 36hg18NCBI36
Build 34541,178,092 - 41,249,369NCBI
Celera541,030,916 - 41,150,111 (-)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef541,094,469 - 41,213,870 (-)NCBIHuRef
CHM1_1541,144,249 - 41,263,574 (-)NCBICHM1_1
T2T-CHM13v2.0541,398,594 - 41,517,945 (-)NCBIT2T-CHM13v2.0
C6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39154,756,550 - 4,833,527 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl154,756,657 - 4,844,449 (+)EnsemblGRCm39 Ensembl
GRCm38154,727,067 - 4,804,045 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl154,727,175 - 4,814,967 (+)EnsemblGRCm38mm10GRCm38
MGSCv37154,677,210 - 4,754,045 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36154,677,212 - 4,754,044 (+)NCBIMGSCv36mm8
Celera154,580,241 - 4,656,631 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.97NCBI
C6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8255,573,596 - 55,648,857 (+)NCBIGRCr8
mRatBN7.2253,846,028 - 53,921,279 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl253,851,985 - 53,921,275 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx260,958,141 - 61,035,012 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0259,016,847 - 59,093,705 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0254,022,072 - 54,097,285 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0254,460,333 - 54,533,801 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl254,466,280 - 54,533,797 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0273,494,910 - 73,562,334 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4253,691,290 - 53,764,539 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1253,619,522 - 53,692,772 (+)NCBI
Celera249,510,682 - 49,574,053 (+)NCBICelera
Cytogenetic Map2q16NCBI
C6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2469,076,007 - 69,197,128 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1567,229,638 - 67,350,759 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0569,174,411 - 69,245,801 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1574,171,926 - 74,288,590 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl574,216,244 - 74,288,588 (+)Ensemblpanpan1.1panPan2
C6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1468,223,626 - 68,318,773 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl468,253,255 - 68,318,252 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha467,906,727 - 68,001,886 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0468,735,676 - 68,831,218 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl468,735,478 - 68,831,020 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1468,496,658 - 68,591,527 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0468,608,273 - 68,703,504 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0469,147,692 - 69,242,660 (+)NCBIUU_Cfam_GSD_1.0
C6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213229,837,753 - 229,916,130 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365181,471,355 - 1,532,439 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365181,471,116 - 1,532,733 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1626,020,628 - 26,084,652 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11626,023,646 - 26,089,518 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21627,211,345 - 27,261,841 (-)NCBISscrofa10.2Sscrofa10.2susScr3
C6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1439,912,385 - 40,033,338 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl439,912,155 - 39,983,634 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607130,341,029 - 30,411,917 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000007380   ⟹   ENSHGLP00000007295
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475913,775,358 - 13,842,648 (+)Ensembl
RefSeq Acc Id: XM_004848576   ⟹   XP_004848633
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475913,775,339 - 13,842,415 (+)NCBI
RefSeq Acc Id: XM_004848577   ⟹   XP_004848634
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475913,775,754 - 13,842,415 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004848633 (Get FASTA)   NCBI Sequence Viewer  
  XP_004848634 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB16524 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000007295
  ENSHGLP00100014442
GenBank Protein JAN99469 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004848633   ⟸   XM_004848576
- UniProtKB: A0A0N8ETK0 (UniProtKB/TrEMBL),   G5C4R3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004848634   ⟸   XM_004848577
- UniProtKB: A0A0N8ETK0 (UniProtKB/TrEMBL),   G5C4R3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000007295   ⟸   ENSHGLT00000007380


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005314 Ensembl, ENTREZGENE
  ENSHGLG00100010682 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000007380 ENTREZGENE
  ENSHGLT00100014603 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  3.30.60.30 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
InterPro C6_KAZAL UniProtKB/TrEMBL
  C8A_B_C6_EGF-like UniProtKB/TrEMBL
  FacI_MAC UniProtKB/TrEMBL
  Kazal_dom UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  MAC_perforin UniProtKB/TrEMBL
  MACPF UniProtKB/TrEMBL
  MACPF_CS UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
KEGG Report hgl:101719948 UniProtKB/TrEMBL
NCBI Gene C6 ENTREZGENE
PANTHER COMPLEMENT COMPONENT C6 UniProtKB/TrEMBL
  COMPLEMENT COMPONENT C6 UniProtKB/TrEMBL
Pfam C6_KAZAL UniProtKB/TrEMBL
  C8A_B_C6_EGF-like UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  MACPF UniProtKB/TrEMBL
  Sushi UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PRINTS COMPLEMENTC9 UniProtKB/TrEMBL
PROSITE KAZAL_2 UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  MACPF_1 UniProtKB/TrEMBL
  MACPF_2 UniProtKB/TrEMBL
  SUSHI UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART CCP UniProtKB/TrEMBL
  FIMAC UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  MACPF UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP SSF57424 UniProtKB/TrEMBL
  SSF57535 UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt A0A0N8ETK0 ENTREZGENE, UniProtKB/TrEMBL
  G5C4R3 ENTREZGENE, UniProtKB/TrEMBL