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ONTOLOGY REPORT - ANNOTATIONS


Term:complement activation
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Accession:GO:0006956 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
Synonyms:exact_synonym: complement cascade;   complement response
 related_synonym: complement activity



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complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1s complement C1s involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
JBrowse link
G C2 complement C2 involved_in ISO
IBA
(PMID:19302245)
GO_REF:0000033
RGD
GO_Central
PMID:19302245 GO_REF:0000033 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G C3 complement C3 acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
(PMID:18947875), (PMID:25284781)
GO_REF:0000033
(PMID:19302245)
RGD
GO_Central
PMID:18947875 PMID:19302245 PMID:25284781 PMID:20712003 GO_REF:0000033, RGD:5129529 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C4a complement C4A acts_upstream_of_or_within
involved_in
TAS
ISO
IBA
(PMID:1438267), (PMID:8133084)
GO_REF:0000033
UniProtKB:P0C0L5 (PMID:19302245)
RGD
GO_Central
PMID:1438267 PMID:8133084 PMID:19302245 PMID:11773063 GO_REF:0000033, RGD:1302926 NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080
JBrowse link
G C4b complement C4B involved_in
acts_upstream_of_or_within
ISO
IBA
UniProtKB:P0C0L4|UniProtKB:P0C0L5 (PMID:19302245)
MGI:1889070 (PMID:12421924)
GO_REF:0000033
RGD
GO_Central
PMID:12421924 PMID:19302245 GO_REF:0000033 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G C6 complement C6 involved_in ISO
IBA
(PMID:2808363)
GO_REF:0000033
RGD
GO_Central
PMID:2808363 GO_REF:0000033 NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275
JBrowse link
G C8a complement C8 alpha chain acts_upstream_of_or_within
involved_in
ISO
IBA
(PMID:12413696)
GO_REF:0000033
RGD
GO_Central
PMID:12413696 GO_REF:0000033 NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754
JBrowse link
G C8b complement C8 beta chain involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565
JBrowse link
G C8g complement C8 gamma chain involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:8,320,503...8,322,087
Ensembl chr 3:8,305,920...8,323,495
JBrowse link
G C9 complement C9 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338
JBrowse link
G Cfb complement factor B involved_in IDA
IBA
GO_REF:0000033 GO_Central
RGD
PMID:6906329 GO_REF:0000033, RGD:2311339 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Cfh complement factor H acts_upstream_of_or_within
involved_in
IEP
ISO
IBA
(PMID:15574507), (PMID:17517971), (PMID:17921253), (PMID:19411110), (PMID:19541934), (PMID:20675597), (PMID:20702729), (PMID:28057640)
GO_REF:0000033
(PMID:24835392)
RGD
GO_Central
PMID:15574507 PMID:17517971 PMID:17921253 PMID:19411110 PMID:19541934 More... GO_REF:0000033, RGD:1599888 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Cfhr1 complement factor H-related 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:51,395,583...51,410,571
Ensembl chr13:51,369,211...51,410,592
JBrowse link
G Cfhr2 complement factor H-related 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:51,175,824...51,247,924
Ensembl chr13:51,175,841...51,247,495
JBrowse link
G Cfhr4 complement factor H-related 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:51,422,592...51,491,476
Ensembl chr13:51,422,592...51,491,502
JBrowse link
G Cfi complement factor I involved_in ISO (PMID:18202746) RGD PMID:18202746 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
JBrowse link
G Colec11 collectin sub-family member 11 involved_in ISO (PMID:23954398) RGD PMID:23954398 NCBI chr 6:45,223,974...45,256,640
Ensembl chr 6:45,223,980...45,271,145
JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within ISO (PMID:20675597) RGD PMID:20675597 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Lcn12 lipocalin 12 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:8,312,412...8,315,392
Ensembl chr 3:8,305,920...8,323,495
JBrowse link
G Masp1 MBL associated serine protease 1 involved_in NAS
IEA
GO_REF:0000002 InterPro
RGD
PMID:12847554 GO_REF:0000002, RGD:633273 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
JBrowse link
G Masp2 MBL associated serine protease 2 NAS RGD PMID:10586086 RGD:633276 NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580
JBrowse link
G Rgcc regulator of cell cycle involved_in ISO (PMID:19162005) RGD PMID:19162005 NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141
JBrowse link
activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H acts_upstream_of_or_within ISO (PMID:20813971) RGD PMID:20813971 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C5 complement C5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G C5l1 complement C5 like 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:18,401,716...18,420,064
Ensembl chr 3:18,404,899...18,420,054
JBrowse link
G C8a complement C8 alpha chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754
JBrowse link
G C8b complement C8 beta chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565
JBrowse link
G C9 complement C9 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338
JBrowse link
G Cfb complement factor B acts_upstream_of_or_within ISO MGI:1861129 (PMID:27564415), (PMID:9238044) RGD PMID:9238044 PMID:27564415 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Cfd complement factor D involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:27564415)
Ensembl
RGD
PMID:27564415 GO_REF:0000107 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
JBrowse link
G Cfh complement factor H acts_upstream_of_or_within
acts_upstream_of_or_within_negative_effect
ISO (PMID:27564415)
(PMID:19828624)
RGD PMID:19828624 PMID:27564415 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Cfp complement factor properdin involved_in ISO MGI:3774548 (PMID:18292556) RGD PMID:18292556 NCBI chr  X:1,162,014...1,167,576
Ensembl chr  X:1,161,979...1,167,573
JBrowse link
G Cr2 complement C3d receptor 2 involved_in
acts_upstream_of_or_within_negative_effect
ISO (PMID:11981823)
(PMID:19828624)
RGD PMID:11981823 PMID:19828624 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235
JBrowse link
complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07006691.1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 1:228,016,498...228,043,066 JBrowse link
G C1qa complement C1q A chain involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:29449492)
MGI:2158701 (PMID:11901193)
GO_REF:0000107
RGD
Ensembl
PMID:11901193 PMID:29449492 GO_REF:0000107 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C1qb complement C1q B chain involved_in ISO (PMID:29449492) RGD PMID:29449492 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
JBrowse link
G C1qbp complement C1q binding protein involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
JBrowse link
G C1qc complement C1q C chain involved_in ISO
IEA
(PMID:29449492)
GO_REF:0000107
RGD
Ensembl
PMID:29449492 GO_REF:0000107 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G C1r complement C1r involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
JBrowse link
G C1rl complement C1r subcomponent like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:157,394,183...157,410,771
Ensembl chr 4:157,394,200...157,410,134
JBrowse link
G C1s complement C1s involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
JBrowse link
G C2 complement C2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G C3 complement C3 involved_in TAS
IEA
GO_REF:0000043 UniProt
RGD
PMID:16996480 GO_REF:0000043, RGD:1600605 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C4a complement C4A involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080
JBrowse link
G C4b complement C4B involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G C4bpa complement component 4 binding protein, alpha involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
JBrowse link
G C4bpb complement component 4 binding protein, beta involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
JBrowse link
G C5 complement C5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G C5l1 complement C5 like 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:18,401,716...18,420,064
Ensembl chr 3:18,404,899...18,420,054
JBrowse link
G C6 complement C6 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275
JBrowse link
G C8a complement C8 alpha chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754
JBrowse link
G C8b complement C8 beta chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565
JBrowse link
G C9 complement C9 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338
JBrowse link
G Cfb complement factor B involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Cfi complement factor I involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Crp C-reactive protein IMP RGD PMID:16367929 RGD:1580273 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G ENSRNOG00000065917 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 6:132,469,837...132,473,735 JBrowse link
G IgG-2a gamma-2a immunoglobulin heavy chain involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Igh-6 immunoglobulin heavy chain 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Ighg1 immunoglobulin heavy constant gamma 1 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
(PMID:6952213)
GO_Central
RGD
PMID:6952213 GO_REF:0000033 Ensembl chr 6:132,389,370...132,393,397 JBrowse link
G Ighm immunoglobulin heavy constant epsilon involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 6:132,329,269...133,053,426 JBrowse link
G Masp2 MBL associated serine protease 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580
JBrowse link
G Mbl1 mannose binding lectin 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174
JBrowse link
G Mbl2 mannose binding lectin 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Serping1 serpin family G member 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
JBrowse link
complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07006691.1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 1:228,016,498...228,043,066 JBrowse link
G Cd69 Cd69 molecule TAS RGD PMID:11034393 PMID:15506986 RGD:1354527, RGD:1354528 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
JBrowse link
G Colec10 collectin subfamily member 10 involved_in ISO (PMID:24174618) RGD PMID:24174618 NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675
JBrowse link
G Colec11 collectin sub-family member 11 involved_in ISO (PMID:24174618), (PMID:25912189) RGD PMID:24174618 PMID:25912189 NCBI chr 6:45,223,974...45,256,640
Ensembl chr 6:45,223,980...45,271,145
JBrowse link
G Fcna ficolin A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:8,445,904...8,449,128
Ensembl chr 3:8,445,907...8,449,105
JBrowse link
G Fcnb ficolin B involved_in ISO
IBA
(PMID:16116205)
GO_REF:0000033
RGD
GO_Central
PMID:16116205 GO_REF:0000033 NCBI chr 3:11,393,713...11,402,198
Ensembl chr 3:11,393,739...11,402,151
JBrowse link
G Krt1 keratin 1 involved_in ISO
IEA
UniProtKB:P11226 (PMID:11549596)
GO_REF:0000107
RGD
Ensembl
PMID:11549596 GO_REF:0000107 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISS
IBA
IEA
ISO
GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(MGI:3789229|PMID:18424734)
(PMID:17182967)
UniProt
GO_Central
Ensembl
RGD
PMID:17182967 PMID:18424734 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:3789229 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
JBrowse link
G Masp2 MBL associated serine protease 2 involved_in ISO
IBA
IEA
(PMID:17182967), (PMID:9087411)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:9087411 PMID:17182967 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580
JBrowse link
G Mbl1 mannose binding lectin 1 acts_upstream_of_or_within IDA
ISO
MGI:96924 (PMID:15148336) RGD PMID:15148336 PMID:16272342 RGD:1582134 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174
JBrowse link
G Mbl2 mannose binding lectin 2 acts_upstream_of_or_within
involved_in
ISO (PMID:15148336)
MGI:3577339|MGI:96923 (PMID:15148336)
UniProtKB:P04264 (PMID:11549596), (PMID:22691502), (PMID:35102342)
RGD PMID:11549596 PMID:15148336 PMID:22691502 PMID:35102342 NCBI chr 1:228,016,439...228,024,736 JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59b CD59b molecule acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
(PMID:10946279), (PMID:11471050)
GO_REF:0000033
RGD
GO_Central
PMID:10946279 PMID:11471050 PMID:15843577 GO_REF:0000033, RGD:1600482 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G LOC134480016 urinary protein 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Rup2l2 urinary protein 2 like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:35,750,482...35,754,083
Ensembl chr 8:35,750,482...35,754,071
JBrowse link
negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) involved_in IDA
ISO
(PMID:28657829), (PMID:6211481) RGD PMID:6211481 PMID:28657829 PMID:10929073 RGD:2326180 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Cd59b CD59b molecule acts_upstream_of_or_within ISO (PMID:10946279) RGD PMID:10946279 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within IMP
ISO
MGI:2158683 (PMID:10642554) RGD PMID:10642554 PMID:11861390 RGD:625470 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISO (PMID:11485744) RGD PMID:11485744 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) RGD PMID:9029106 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO
IBA
(PMID:23482636)
GO_REF:0000033
RGD
GO_Central
PMID:23482636 GO_REF:0000033 NCBI chr13:94,455,180...94,577,773
Ensembl chr13:94,455,165...94,577,750
JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in ISO
IBA
UniProtKB:P01024 (PMID:17051150)
GO_REF:0000033
RGD
GO_Central
PMID:17051150 GO_REF:0000033 NCBI chr  X:61,144,926...61,170,212
Ensembl chr  X:61,144,928...61,170,212
JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4bpa complement component 4 binding protein, alpha involved_in ISO
IEA
IBA
(PMID:22333221)
GO_REF:0000107
GO_REF:0000033
RGD
Ensembl
GO_Central
PMID:22333221 GO_REF:0000033 GO_REF:0000107 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
JBrowse link
G C4bpb complement component 4 binding protein, beta involved_in ISO
IEA
(PMID:22333221)
GO_REF:0000107
RGD
Ensembl
PMID:22333221 GO_REF:0000107 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
JBrowse link
G Cd46 CD46 molecule involved_in ISO
IBA
(PMID:9029106)
GO_REF:0000033
RGD
GO_Central
PMID:9029106 GO_REF:0000033 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Cd46l1 CD46 molecule like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:33,996,404...33,997,405
Ensembl chr20:33,996,224...33,997,432
JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Cr2 complement C3d receptor 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235
JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO
IBA
(PMID:23482636)
GO_REF:0000033
RGD
GO_Central
PMID:23482636 GO_REF:0000033 NCBI chr13:94,455,180...94,577,773
Ensembl chr13:94,455,165...94,577,750
JBrowse link
G Svep1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:72,811,200...72,988,185
Ensembl chr 5:72,811,410...72,988,525
JBrowse link
G Zp3r zona pellucida 3 receptor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:42,019,998...42,064,836
Ensembl chr13:42,020,018...42,064,812
JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin involved_in ISO (PMID:12538697) RGD PMID:12538697 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Serping1 serpin family G member 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:10946292)
UniProt
RGD
PMID:10946292 GO_REF:0000024 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA
ISO
GO_REF:0000107
(MGI:4430818|PMID:15611275)
Ensembl
RGD
PMID:15611275 GO_REF:0000107 MGI:4430818 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C6 complement C6 involved_in ISO (MGI:4430818|PMID:15611275) RGD PMID:15611275 MGI:4430818 NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275
JBrowse link
positive regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C6 complement C6 involved_in ISO (MGI:4430818|PMID:15611275) RGD PMID:15611275 MGI:4430818 NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275
JBrowse link
G Il1b interleukin 1 beta involved_in ISO RNAcentral:URS0000424278_9606 (PMID:29384235) RGD PMID:29384235 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mbl2 mannose binding lectin 2 IDA RGD PMID:9920905 RGD:4889148 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Phb1 prohibitin 1 involved_in ISO (PMID:17070910) RGD PMID:17070910 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
JBrowse link
positive regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6275756|PMID:30548312) RGD PMID:30548312 MGI:6275756 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in ISS
ISO
IEA
IBA
GO_REF:0000024
(PMID:8195709)
GO_REF:0000107
GO_REF:0000033
UniProt
RGD
Ensembl
GO_Central
PMID:8195709 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:25284781) RGD PMID:25284781 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Cd59b CD59b molecule acts_upstream_of_or_within NAS
ISO
(PMID:25284781) RGD PMID:25284781 PMID:7528012 RGD:727654 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cd5l Cd5 molecule-like acts_upstream_of_or_within ISO MGI:2653296 (PMID:25284781) RGD PMID:25284781 NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753
JBrowse link
G Cfh complement factor H acts_upstream_of_or_within IDA
ISO
MGI:2384179 (PMID:18947875)
(PMID:25284781)
RGD PMID:18947875 PMID:25284781 PMID:12374811 RGD:628500 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within ISO (PMID:25284781)
MGI:2158683 (PMID:18947875)
RGD PMID:18947875 PMID:25284781 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Phb2 prohibitin 2 NOT|involved_in ISO (PMID:17070910) RGD PMID:17070910 NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272
JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) RGD PMID:23482636 NCBI chr13:94,455,180...94,577,773
Ensembl chr13:94,455,165...94,577,750
JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H involved_in ISO (PMID:20378178), (PMID:28671664) RGD PMID:20378178 PMID:28671664 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO MGI:2387405 (PMID:9892684) RGD PMID:9892684 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19870
    immune system process 2843
      immune effector process 733
        complement activation 66
          activation of membrane attack complex + 6
          complement activation, alternative pathway + 14
          complement activation, classical pathway + 41
          complement activation, lectin pathway + 13
          negative regulation of complement activation + 17
          positive regulation of complement activation + 6
          regulation of complement activation + 27
Path 2
Term Annotations click to browse term
  biological_process 19870
    biological regulation 13395
      regulation of biological process 12997
        positive regulation of biological process 6679
          positive regulation of response to stimulus 2496
            positive regulation of immune response 782
              activation of immune response 563
                complement activation 66
                  activation of membrane attack complex + 6
                  complement activation, alternative pathway + 14
                  complement activation, classical pathway + 41
                  complement activation, lectin pathway + 13
                  negative regulation of complement activation + 17
                  positive regulation of complement activation + 6
                  regulation of complement activation + 27
paths to the root