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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation
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Accession:GO:0006956 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
Synonyms:exact_synonym: complement cascade;   complement response
 related_synonym: complement activity


show annotations for term's descendants           Sort by:
complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1r complement C1r involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484 		JBrowse link
G C1s complement C1s involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303 		JBrowse link
G C2 complement C2 involved_in ISO
IBA		 (PMID:19302245)
PMID:21873635
(PMID:12878586), (PMID:6906228)		 RGD PMID:6906228 PMID:12878586 PMID:19302245 PMID:21873635 RGD:13792537 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G C3 complement C3 involved_in
acts_upstream_of_or_within		 IDA
ISO
IBA		 (PMID:12878586), (PMID:6225800)
(MGI:3833206|PMID:18947875), (MGI:5617896|PMID:25284781)
PMID:21873635
(PMID:19302245)		 RGD PMID:6225800 PMID:12878586 PMID:18947875 PMID:19302245 PMID:25284781 More... MGI:3833206 MGI:5617896, RGD:5129529, RGD:13792537 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C4a complement C4A involved_in
acts_upstream_of_or_within		 TAS
ISO
IBA		 (PMID:12878586), (PMID:6906228)
(MGI:51812|PMID:1438267), (MGI:66045|PMID:8133084)
UniProtKB:P0C0L5 (PMID:19302245)
PMID:21873635		 RGD PMID:1438267 PMID:6906228 PMID:8133084 PMID:12878586 PMID:19302245 More... MGI:51812 MGI:66045, RGD:1302926, RGD:13792537 NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080 		JBrowse link
G C4b complement C4B (Chido blood group) involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(PMID:12878586), (PMID:6906228)
MGI:1889070 (MGI:2429478|PMID:12421924)
UniProtKB:P0C0L4|UniProtKB:P0C0L5 (PMID:19302245)		 RGD PMID:6906228 PMID:12421924 PMID:12878586 PMID:19302245 PMID:21873635 MGI:2429478, RGD:13792537 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G C5 complement C5 involved_in ISO (PMID:2808363) RGD PMID:2808363 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C6 complement C6 involved_in ISO
IBA		 (PMID:2808363)
PMID:21873635		 RGD PMID:2808363 PMID:21873635 RGD:13792537 NCBI chr 2:53,846,027...53,921,279
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G C8a complement C8 alpha chain acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:12413696)
PMID:21873635		 RGD PMID:12413696 PMID:21873635 RGD:13792537 NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G C8b complement C8 beta chain involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565 		JBrowse link
G C8g complement C8 gamma chain involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:8,320,495...8,323,495
Ensembl chr 3:8,305,920...8,323,495 		JBrowse link
G C9 complement C9 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Cfb complement factor B involved_in IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:6906329 PMID:21873635 RGD:2311339, RGD:13792537 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfh complement factor H involved_in
acts_upstream_of_or_within		 IEP
IBA
ISO		 PMID:21873635
(MGI:3639077|PMID:15574507), (MGI:3760048|PMID:17517971), (MGI:3760334|PMID:17921253), (MGI:3848672|PMID:19411110), (MGI:3849508|PMID:19541934), (MGI:4821502|PMID:20675597), (MGI:4830025|PMID:20702729), (MGI:5883383|PMID:28057640)
(PMID:24835392)		 RGD PMID:15574507 PMID:17517971 PMID:17921253 PMID:19411110 PMID:19541934 More... MGI:3639077 MGI:3760048 MGI:3760334 MGI:3848672 MGI:3849508 MGI:4821502 MGI:4830025 MGI:5883383, RGD:1599888, RGD:13792537 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cfhr1 complement factor H-related 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:51,395,583...51,410,571
Ensembl chr13:51,369,211...51,410,592 		JBrowse link
G Cfhr2 complement factor H-related 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:51,175,824...51,247,924
Ensembl chr13:51,175,841...51,247,495 		JBrowse link
G Cfhr4 complement factor H-related 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:51,422,592...51,491,476
Ensembl chr13:51,422,592...51,491,502 		JBrowse link
G Cfi complement factor I involved_in ISO (MGI:3773599|PMID:18202746) RGD PMID:18202746 MGI:3773599 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Colec11 collectin sub-family member 11 involved_in ISO (PMID:23954398) RGD PMID:23954398 NCBI chr 6:45,223,974...45,256,640
Ensembl chr 6:45,223,980...45,271,145 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within ISO (MGI:4821502|PMID:20675597) RGD PMID:20675597 MGI:4821502 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Lcn12 lipocalin 12 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:8,312,404...8,320,206
Ensembl chr 3:8,305,920...8,323,495 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in NAS
IEA		 GO_REF:0000002 InterPro
RGD		 PMID:12847554 GO_REF:0000002, RGD:633273 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974 		JBrowse link
G Masp2 MBL associated serine protease 2 NAS RGD PMID:10586086 RGD:633276 NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580 		JBrowse link
G Rgcc regulator of cell cycle involved_in ISO (PMID:19162005) RGD PMID:19162005 NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141 		JBrowse link
activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H acts_upstream_of_or_within ISO (MGI:4837299|PMID:20813971) RGD PMID:20813971 MGI:4837299 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C5 complement C5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C8a complement C8 alpha chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G C8b complement C8 beta chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565 		JBrowse link
G C9 complement C9 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Cfb complement factor B acts_upstream_of_or_within ISO MGI:1861129 (MGI:1096110|PMID:9238044), (MGI:6100611|PMID:27564415) RGD PMID:9238044 PMID:27564415 MGI:1096110 MGI:6100611 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfd complement factor D involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:6100611|PMID:27564415)		 Ensembl
RGD		 PMID:27564415 GO_REF:0000107 MGI:6100611 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053 		JBrowse link
G Cfh complement factor H acts_upstream_of_or_within_negative_effect ISO (MGI:4421084|PMID:19828624)
(MGI:6100611|PMID:27564415)		 RGD PMID:19828624 PMID:27564415 MGI:4421084 MGI:6100611 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cfp complement factor properdin involved_in ISO MGI:3774548 (MGI:3773929|PMID:18292556) RGD PMID:18292556 MGI:3773929 NCBI chr  X:1,162,014...1,167,576
Ensembl chr  X:1,161,979...1,167,573 		JBrowse link
G Cr2 complement C3d receptor 2 involved_in
acts_upstream_of_or_within_negative_effect		 ISO (PMID:11981823)
(MGI:4421084|PMID:19828624)		 RGD PMID:11981823 PMID:19828624 MGI:4421084 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235 		JBrowse link
G RGD1308742 similar to Complement C5 precursor involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:18,401,716...18,420,064
Ensembl chr 3:18,404,899...18,420,054 		JBrowse link
complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qa complement C1q A chain acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:2158701 (MGI:2177393|PMID:11901193)
GO_REF:0000107
(PMID:29449492)		 RGD
Ensembl		 PMID:11901193 PMID:29449492 GO_REF:0000107 MGI:2177393 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qb complement C1q B chain involved_in ISO (PMID:29449492) RGD PMID:29449492 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G C1qbp complement C1q binding protein involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G C1qc complement C1q C chain involved_in ISO
IEA		 (PMID:29449492)
GO_REF:0000107		 RGD
Ensembl		 PMID:29449492 GO_REF:0000107 NCBI chr 5:149,127,424...149,130,732
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C1rl complement C1r subcomponent like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:157,394,183...157,410,771
Ensembl chr 4:157,394,200...157,410,134 		JBrowse link
G C1s complement C1s involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303 		JBrowse link
G C2 complement C2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G C3 complement C3 involved_in TAS
IEA		 GO_REF:0000043 UniProt
RGD		 PMID:16996480 GO_REF:0000043, RGD:1600605 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C4a complement C4A involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080 		JBrowse link
G C4b complement C4B (Chido blood group) involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G C4bpa complement component 4 binding protein, alpha involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C4bpb complement component 4 binding protein, beta involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817 		JBrowse link
G C5 complement C5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C6 complement C6 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:53,846,027...53,921,279
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G C8a complement C8 alpha chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G C8b complement C8 beta chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565 		JBrowse link
G C9 complement C9 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Cfb complement factor B involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfi complement factor I involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Crp C-reactive protein IMP RGD PMID:16367929 RGD:1580273 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G IgG-2a gamma-2a immunoglobulin heavy chain involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Igh-6 immunoglobulin heavy chain 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Ighg1 immunoglobulin heavy constant gamma 1 acts_upstream_of_or_within
involved_in		 ISO
IBA		 (MGI:2683928|PMID:6952213)
PMID:21873635		 RGD PMID:6952213 PMID:21873635 MGI:2683928, RGD:13792537 Ensembl chr 6:132,389,370...132,393,397 JBrowse link
G Ighm immunoglobulin heavy constant epsilon involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 6:132,329,269...133,053,426 JBrowse link
G LOC362795 immunoglobulin G heavy chain involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Masp2 MBL associated serine protease 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580 		JBrowse link
G Mbl1 mannose binding lectin 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174 		JBrowse link
G Mbl2 mannose binding lectin 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G RGD1308742 similar to Complement C5 precursor involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:18,401,716...18,420,064
Ensembl chr 3:18,404,899...18,420,054 		JBrowse link
G Serping1 serpin family G member 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 Cd69 molecule TAS RGD PMID:11034393 PMID:15506986 RGD:1354527, RGD:1354528 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Colec10 collectin subfamily member 10 involved_in ISO (PMID:24174618) RGD PMID:24174618 NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675 		JBrowse link
G Colec11 collectin sub-family member 11 involved_in ISO (PMID:24174618), (PMID:25912189) RGD PMID:24174618 PMID:25912189 NCBI chr 6:45,223,974...45,256,640
Ensembl chr 6:45,223,980...45,271,145 		JBrowse link
G Fcna ficolin A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:8,445,904...8,449,128
Ensembl chr 3:8,445,907...8,449,105 		JBrowse link
G Fcnb ficolin B involved_in ISO
IBA		 (PMID:16116205)
PMID:21873635		 RGD PMID:16116205 PMID:21873635 RGD:13792537 NCBI chr 3:11,393,771...11,402,198
Ensembl chr 3:11,393,739...11,402,151 		JBrowse link
G Krt1 keratin 1 involved_in ISO
IEA		 UniProtKB:P11226 (PMID:11549596)
GO_REF:0000107		 RGD
Ensembl		 PMID:11549596 GO_REF:0000107 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000107
PMID:21873635
(PMID:10679061), (PMID:11907111), (PMID:16116205), (PMID:22691502), (PMID:24174618)
(MGI:3789229|PMID:18424734)
(PMID:17182967)		 UniProt
Ensembl
RGD		 PMID:10679061 PMID:11907111 PMID:16116205 PMID:17182967 PMID:18424734 More... GO_REF:0000024 GO_REF:0000107 MGI:3789229, RGD:13792537 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974 		JBrowse link
G Masp2 MBL associated serine protease 2 involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA		 (PMID:17182967), (PMID:9087411)
PMID:21873635
(PMID:10679061), (PMID:11907111), (PMID:16116205), (PMID:22691502), (PMID:24174618)
(MGI:5473786|PMID:16328467)
GO_REF:0000107		 RGD
Ensembl		 PMID:9087411 PMID:10679061 PMID:11907111 PMID:16116205 PMID:16328467 More... GO_REF:0000107 MGI:5473786, RGD:13792537 NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580 		JBrowse link
G Mbl1 mannose binding lectin 1 acts_upstream_of_or_within IDA
ISO		 MGI:96924 (MGI:3577322|PMID:15148336) RGD PMID:15148336 PMID:16272342 MGI:3577322, RGD:1582134 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174 		JBrowse link
G Mbl2 mannose binding lectin 2 acts_upstream_of_or_within
involved_in		 ISO MGI:3577339|MGI:96923 (MGI:3577322|PMID:15148336)
UniProtKB:P04264 (PMID:11549596), (PMID:22691502), (PMID:35102342)
(PMID:15148336)		 RGD PMID:11549596 PMID:15148336 PMID:22691502 PMID:35102342 MGI:3577322 NCBI chr 1:228,016,439...228,024,736 JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59b CD59b molecule acts_upstream_of_or_within
involved_in		 IDA
ISO
IBA		 (MGI:1888643|PMID:10946279), (MGI:2148385|PMID:11471050)
PMID:21873635		 RGD PMID:10946279 PMID:11471050 PMID:15843577 PMID:21873635 MGI:1888643 MGI:2148385, RGD:1600482, RGD:13792537 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G LOC680367 similar to Urinary protein 3 precursor (RUP-3) involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) involved_in IDA
ISO		 (PMID:28657829), (PMID:6211481) RGD PMID:6211481 PMID:28657829 PMID:10929073 RGD:2326180 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cd59b CD59b molecule acts_upstream_of_or_within ISO (MGI:1888643|PMID:10946279) RGD PMID:10946279 MGI:1888643 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within IMP
ISO		 MGI:2158683 (MGI:1351571|PMID:10642554) RGD PMID:10642554 PMID:11861390 MGI:1351571, RGD:625470 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISO (PMID:11485744) RGD PMID:11485744 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) RGD PMID:9029106 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO
IBA		 (PMID:23482636)
PMID:21873635		 RGD PMID:23482636 PMID:21873635 RGD:13792537 NCBI chr13:94,455,180...94,577,773
Ensembl chr13:94,455,165...94,577,750 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in IBA
ISO		 PMID:21873635
UniProtKB:P01024 (PMID:17051150)		 RGD PMID:17051150 PMID:21873635 RGD:13792537 NCBI chr  X:61,144,926...61,170,212
Ensembl chr  X:61,144,928...61,170,212 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4bpa complement component 4 binding protein, alpha involved_in ISO
IEA
IBA		 (PMID:22333221)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:22333221 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C4bpb complement component 4 binding protein, beta involved_in ISO
IEA		 (PMID:22333221)
GO_REF:0000107		 RGD
Ensembl		 PMID:22333221 GO_REF:0000107 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817 		JBrowse link
G Cd46 CD46 molecule involved_in ISO
IBA		 (PMID:9029106)
PMID:21873635		 RGD PMID:9029106 PMID:21873635 RGD:13792537 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cr2 complement C3d receptor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235 		JBrowse link
G RGD1559810 similar to hypothetical protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:33,996,404...33,997,405
Ensembl chr20:33,996,224...33,997,432 		JBrowse link
G Susd4 sushi domain containing 4 involved_in IBA
ISO		 PMID:21873635
(PMID:23482636)		 RGD PMID:23482636 PMID:21873635 RGD:13792537 NCBI chr13:94,455,180...94,577,773
Ensembl chr13:94,455,165...94,577,750 		JBrowse link
G Svep1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:72,811,200...72,988,813
Ensembl chr 5:72,811,410...72,988,525 		JBrowse link
G Zp3r zona pellucida 3 receptor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:42,019,998...42,064,836
Ensembl chr13:42,020,018...42,064,812 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin involved_in ISO (PMID:12538697) RGD PMID:12538697 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Serping1 serpin family G member 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:10946292)		 UniProt
RGD		 PMID:10946292 GO_REF:0000024 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA
ISO		 GO_REF:0000107
(MGI:4430818|PMID:15611275)		 Ensembl
RGD		 PMID:15611275 GO_REF:0000107 MGI:4430818 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C6 complement C6 involved_in ISO (MGI:4430818|PMID:15611275) RGD PMID:15611275 MGI:4430818 NCBI chr 2:53,846,027...53,921,279
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
positive regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C6 complement C6 involved_in ISO (MGI:4430818|PMID:15611275) RGD PMID:15611275 MGI:4430818 NCBI chr 2:53,846,027...53,921,279
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO RNAcentral:URS0000424278_9606 (PMID:29384235) RGD PMID:29384235 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mbl2 mannose binding lectin 2 IDA RGD PMID:9920905 RGD:4889148 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Phb1 prohibitin 1 involved_in ISO (PMID:17070910) RGD PMID:17070910 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
positive regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6275756|PMID:30548312) RGD PMID:30548312 MGI:6275756 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:8195709)
PMID:21873635
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:8195709 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G C3 complement C3 involved_in ISO (PMID:6225800) RGD PMID:6225800 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:25284781) RGD PMID:25284781 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cd59b CD59b molecule acts_upstream_of_or_within NAS
ISO		 (PMID:25284781) RGD PMID:25284781 PMID:7528012 RGD:727654 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cd5l Cd5 molecule-like acts_upstream_of_or_within ISO MGI:2653296 (MGI:5617896|PMID:25284781) RGD PMID:25284781 MGI:5617896 NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753 		JBrowse link
G Cfh complement factor H acts_upstream_of_or_within IDA
ISO		 (PMID:25284781)
MGI:2384179 (MGI:3833206|PMID:18947875)		 RGD PMID:18947875 PMID:25284781 PMID:12374811 MGI:3833206, RGD:628500 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within ISO MGI:2158683 (MGI:3833206|PMID:18947875)
(PMID:25284781)		 RGD PMID:18947875 PMID:25284781 MGI:3833206 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Phb2 prohibitin 2 NOT|involved_in ISO (PMID:17070910) RGD PMID:17070910 NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) RGD PMID:23482636 NCBI chr13:94,455,180...94,577,773
Ensembl chr13:94,455,165...94,577,750 		JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in ISO (PMID:28671664) RGD PMID:28671664 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cfh complement factor H involved_in ISO (PMID:20378178), (PMID:28671664) RGD PMID:20378178 PMID:28671664 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cfi complement factor I involved_in ISO (PMID:28671664) RGD PMID:28671664 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO MGI:2387405 (MGI:1330710|PMID:9892684) RGD PMID:9892684 MGI:1330710 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19818
    immune system process 2627
      immune effector process 710
        complement activation 64
          activation of membrane attack complex + 5
          complement activation, alternative pathway + 15
          complement activation, classical pathway + 39
          complement activation, lectin pathway + 12
          negative regulation of complement activation + 16
          positive regulation of complement activation + 6
          regulation of complement activation + 27
          suppression by virus of host complement activation 0
Path 2
Term Annotations click to browse term
  biological_process 19818
    biological regulation 13487
      regulation of biological process 13074
        positive regulation of biological process 6716
          positive regulation of response to stimulus 2422
            positive regulation of immune response 713
              activation of immune response 488
                complement activation 64
                  activation of membrane attack complex + 5
                  complement activation, alternative pathway + 15
                  complement activation, classical pathway + 39
                  complement activation, lectin pathway + 12
                  negative regulation of complement activation + 16
                  positive regulation of complement activation + 6
                  regulation of complement activation + 27
                  suppression by virus of host complement activation 0
paths to the root