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ONTOLOGY REPORT - ANNOTATIONS

Term:spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
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Accession:GO:0000388 term browser browse the term
Definition:Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11).
Comment:Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian).
Synonyms:narrow_synonym: U12-type spliceosome conformational change to release U4atac and U11;   U2-type spliceosome conformational change to release U4 and U1;   spliceosomal A1 complex biosynthesis;   spliceosomal A1 complex formation;   spliceosomal B2 complex biosynthesis;   spliceosomal B2 complex formation
 broad_synonym: 3'-splice site cleavage, exon ligation
 alt_id: GO:0000396;   GO:0000397


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spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNRNP200 small nuclear ribonucleoprotein U5 subunit 200 involved_in IDA
IBA
IEA		 (PMID:35241646) UniProt
GO_Central
TreeGrafter		 PMID:35241646 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:96,274,338...96,305,546
Ensembl chr 2:96,274,338...96,321,271 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19654
    cellular process 18268
      cellular component organization or biogenesis 7552
        cellular component biogenesis 3859
          ribonucleoprotein complex biogenesis 534
            protein-RNA complex assembly 259
              spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 1
Path 2
Term Annotations click to browse term
  biological_process 19654
    metabolic process 12453
      cellular metabolic process 10633
        cellular biosynthetic process 8807
          macromolecule biosynthetic process 8216
            nucleic acid biosynthetic process 5101
              RNA biosynthetic process 4978
                RNA processing 1542
                  RNA splicing 516
                    RNA splicing, via transesterification reactions 373
                      RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 369
                        mRNA splicing, via spliceosome 369
                          spliceosomal conformational changes to generate catalytic conformation 6
                            spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 1
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