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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA replication checkpoint signaling
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Accession:GO:0000076 term browser browse the term
Definition:A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
Synonyms:exact_synonym: DNA replication checkpoint;   signal transduction involved in DNA replication checkpoint
 alt_id: GO:0072437

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DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:74,190,409...74,196,589
Ensembl chr 5:74,190,947...74,195,972 		JBrowse link
G CLSPN claspin acts_upstream_of_or_within ISO (PMID:12766152)
(PMID:16123041)		 MGI
UniProt		 PMID:12766152 PMID:16123041 NCBI chr20:97,096,529...97,132,305 JBrowse link
G DNA2 DNA replication helicase/nuclease 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:62,926,221...62,985,843
Ensembl chr 9:62,926,674...62,985,842 		JBrowse link
G MDC1 mediator of DNA damage checkpoint 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:41,735,584...41,754,618
Ensembl chr17:41,739,419...41,755,141 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:6,865,990...6,945,179
Ensembl chr 1:6,866,840...6,941,486 		JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:105,738,247...105,772,539
Ensembl chr11:105,738,867...105,772,002 		JBrowse link
G TIMELESS timeless circadian regulator involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:52,371,781...52,408,923
Ensembl chr11:52,372,375...52,389,284 		JBrowse link
G TIPIN TIMELESS interacting protein involved_in IEA UniProt
Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr26:17,194,859...17,214,671
Ensembl chr26:17,198,734...17,214,810 		JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:56,679,333...56,740,773
Ensembl chr15:56,679,426...56,741,566 		JBrowse link
mitotic DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC6 cell division cycle 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:65,873,341...65,888,180
Ensembl chr16:65,871,627...65,888,217 		JBrowse link
G CLSPN claspin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:97,096,529...97,132,305 JBrowse link
G DONSON DNA replication fork stabilization factor DONSON involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:58,598,341...58,627,279
Ensembl chr 2:58,598,967...58,609,316 		JBrowse link
G HUS1 HUS1 checkpoint clamp component involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr21:10,826,799...10,841,579
Ensembl chr21:10,826,846...10,841,382 		JBrowse link
G NAE1 NEDD8 activating enzyme E1 subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:52,502,729...52,531,447
Ensembl chr 5:52,502,546...52,525,262 		JBrowse link
G ORC1 origin recognition complex subunit 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:80,540,331...80,571,989
Ensembl chr20:80,542,532...80,572,237 		JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:65,456,174...65,501,665
Ensembl chr 4:65,457,763...65,501,157 		JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr29:8,117,198...8,171,956 JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:56,679,333...56,740,773
Ensembl chr15:56,679,426...56,741,566 		JBrowse link
G ZNF830 zinc finger protein 830 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:28,468,548...28,470,150
Ensembl chr16:28,468,616...28,469,734 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17022
    cellular process 16536
      signal transduction 5609
        intracellular signal transduction 2997
          cell cycle checkpoint signaling 187
            DNA integrity checkpoint signaling 134
              DNA replication checkpoint signaling 17
                meiotic G2/MI DNA replication checkpoint signaling 0
                mitotic DNA replication checkpoint signaling 10
Path 2
Term Annotations click to browse term
  biological_process 17022
    biological regulation 11823
      regulation of biological process 11434
        negative regulation of biological process 5660
          negative regulation of cellular process 5413
            negative regulation of cell cycle 382
              negative regulation of cell cycle process 304
                negative regulation of cell cycle phase transition 252
                  cell cycle checkpoint signaling 187
                    DNA integrity checkpoint signaling 134
                      DNA replication checkpoint signaling 17
                        meiotic G2/MI DNA replication checkpoint signaling 0
                        mitotic DNA replication checkpoint signaling 10
paths to the root