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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA replication checkpoint signaling
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Accession:GO:0000076 term browser browse the term
Definition:A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
Synonyms:exact_synonym: DNA replication checkpoint;   signal transduction involved in DNA replication checkpoint
 alt_id: GO:0072437


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DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chr 5:74,190,409...74,196,589
Ensembl chr 5:74,190,947...74,195,972
JBrowse link
G CLSPN claspin acts_upstream_of_or_within ISO (PMID:12766152)
(PMID:16123041)
MGI
UniProt
PMID:12766152 PMID:16123041 NCBI chr20:97,096,529...97,132,305 JBrowse link
G DNA2 DNA replication helicase/nuclease 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:62,926,221...62,985,843
Ensembl chr 9:62,926,674...62,985,842
JBrowse link
G MDC1 mediator of DNA damage checkpoint 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:41,735,584...41,754,618
Ensembl chr17:41,739,419...41,755,141
JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:6,865,990...6,945,179
Ensembl chr 1:6,866,840...6,941,486
JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:105,738,247...105,772,539
Ensembl chr11:105,738,867...105,772,002
JBrowse link
G TIMELESS timeless circadian regulator involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:52,371,781...52,408,923
Ensembl chr11:52,372,375...52,389,284
JBrowse link
G TIPIN TIMELESS interacting protein involved_in IEA UniProt
Ensembl
TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr26:17,194,859...17,214,671
Ensembl chr26:17,198,734...17,214,810
JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:56,679,333...56,740,773
Ensembl chr15:56,679,426...56,741,566
JBrowse link
mitotic DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC6 cell division cycle 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:65,873,341...65,888,180
Ensembl chr16:65,871,627...65,888,217
JBrowse link
G CLSPN claspin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:97,096,529...97,132,305 JBrowse link
G DONSON DNA replication fork stabilization factor DONSON involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:58,598,341...58,627,279
Ensembl chr 2:58,598,967...58,609,316
JBrowse link
G HUS1 HUS1 checkpoint clamp component involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr21:10,826,799...10,841,579
Ensembl chr21:10,826,846...10,841,382
JBrowse link
G NAE1 NEDD8 activating enzyme E1 subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:52,502,729...52,531,447
Ensembl chr 5:52,502,546...52,525,262
JBrowse link
G ORC1 origin recognition complex subunit 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:80,540,331...80,571,989
Ensembl chr20:80,542,532...80,572,237
JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:65,456,174...65,501,665
Ensembl chr 4:65,457,763...65,501,157
JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chr29:8,117,198...8,171,956 JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:56,679,333...56,740,773
Ensembl chr15:56,679,426...56,741,566
JBrowse link
G ZNF830 zinc finger protein 830 involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chr16:28,468,548...28,470,150
Ensembl chr16:28,468,616...28,469,734
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17022
    cellular process 16536
      signal transduction 5609
        intracellular signal transduction 2997
          cell cycle checkpoint signaling 187
            DNA integrity checkpoint signaling 134
              DNA replication checkpoint signaling 17
                meiotic G2/MI DNA replication checkpoint signaling 0
                mitotic DNA replication checkpoint signaling 10
Path 2
Term Annotations click to browse term
  biological_process 17022
    biological regulation 11823
      regulation of biological process 11434
        negative regulation of biological process 5660
          negative regulation of cellular process 5413
            negative regulation of cell cycle 382
              negative regulation of cell cycle process 304
                negative regulation of cell cycle phase transition 252
                  cell cycle checkpoint signaling 187
                    DNA integrity checkpoint signaling 134
                      DNA replication checkpoint signaling 17
                        meiotic G2/MI DNA replication checkpoint signaling 0
                        mitotic DNA replication checkpoint signaling 10
paths to the root