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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Arsenic Poisoning
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Accession:DOID:9007964 term browser browse the term
Definition:Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)
Synonyms:exact_synonym: Arsenic Encephalopathies;   Arsenic Encephalopathy;   Arsenic Induced Polyneuropathy;   Arsenic Poisoning, Nervous System;   Arsenic Poisonings;   Arsenic-Induced Polyneuropathies;   Arsenical Neurotoxicity Syndrome;   Arsenical Neurotoxicity Syndromes;   Inorganic Arsenic Poisoning;   Inorganic Arsenic Poisonings;   Nervous System, Organic Arsenic Poisoning;   Organic Arsenic Poisoning;   Organic Arsenic Poisonings
 primary_id: MESH:D020261;   RDO:0007378

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Arsenic Poisoning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap9 A-kinase anchoring protein 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624809:1,101,941...1,258,402
Ensembl chrNW_004624809:1,103,538...1,257,809 		JBrowse link
G Alad aminolevulinate dehydratase ISO protein:decreased activity:blood (rat) RGD PMID:19022878 RGD:4144202 NCBI chrNW_004624760:21,698,689...21,709,907
Ensembl chrNW_004624760:21,698,587...21,711,822 		JBrowse link
G Aqp9 aquaporin 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19805235 NCBI chrNW_004624781:13,650,612...13,691,175
Ensembl chrNW_004624781:13,648,065...13,691,260 		JBrowse link
G Atxn7 ataxin 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624888:1,910,385...2,045,038
Ensembl chrNW_004624888:1,914,063...1,999,755 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624843:2,017,738...2,021,153 JBrowse link
G Ccrl2 C-C motif chemokine receptor like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624730:74,671,736...74,674,030 JBrowse link
G Cd44 CD44 molecule (IN blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624767:11,938,452...12,024,970
Ensembl chrNW_004624767:11,938,028...12,025,069 		JBrowse link
G Cd83 CD83 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624756:12,212,921...12,229,974
Ensembl chrNW_004624756:12,210,892...12,229,749 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A ISO protein:increased expression:skin: RGD PMID:11860939 RGD:8662429 NCBI chrNW_004624754:21,109,074...21,115,869
Ensembl chrNW_004624754:21,108,874...21,115,885 		JBrowse link
G Crp C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:22521605 NCBI chrNW_004624794:1,531,555...1,533,804
Ensembl chrNW_004624794:1,531,571...1,533,804 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12569548 NCBI chrNW_004624907:2,288,380...2,298,909
Ensembl chrNW_004624907:2,288,423...2,298,373 		JBrowse link
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12569548 NCBI chrNW_004624732:13,730,648...13,776,886
Ensembl chrNW_004624732:13,729,947...13,776,870 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12569548 NCBI chrNW_004624782:4,508,758...4,537,751
Ensembl chrNW_004624782:4,512,650...4,537,701 		JBrowse link
G Gadd45b growth arrest and DNA damage inducible beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624828:5,663,604...5,665,666
Ensembl chrNW_004624828:5,663,485...5,665,666 		JBrowse link
G Golga4 golgin A4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624890:931,878...938,932 JBrowse link
G Gsr glutathione-disulfide reductase ISO RGD PMID:25209654 RGD:10401880 NCBI chrNW_004624780:13,440,269...13,497,435
Ensembl chrNW_004624780:13,440,235...13,496,535 		JBrowse link
G Id2 inhibitor of DNA binding 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624846:2,281,292...2,283,596
Ensembl chrNW_004624846:2,277,961...2,283,571 		JBrowse link
G Ier3 immediate early response 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624754:24,991,650...24,992,645
Ensembl chrNW_004624754:24,991,690...24,992,643 		JBrowse link
G Igf2bp2 insulin like growth factor 2 mRNA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chrNW_004624730:70,914,763...71,061,313
Ensembl chrNW_004624730:70,914,804...71,059,642 		JBrowse link
G Il1a interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624749:12,795,967...12,805,658
Ensembl chrNW_004624749:12,795,946...12,805,154 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624749:12,852,128...12,858,478
Ensembl chrNW_004624749:12,852,021...12,858,760 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624749:13,210,365...13,224,471
Ensembl chrNW_004624749:13,210,476...13,225,890 		JBrowse link
G Inpp5a inositol polyphosphate-5-phosphatase A ISO CTD Direct Evidence: marker/mechanism CTD PMID:25759212 NCBI chrNW_004624737:14,048,696...14,300,960
Ensembl chrNW_004624737:14,047,264...14,300,946 		JBrowse link
G Kcnj2 potassium inwardly rectifying channel subfamily J member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624801:365,393...375,802
Ensembl chrNW_004624801:365,361...374,487 		JBrowse link
G Krt10 keratin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19953893 NCBI chrNW_004624795:2,594,973...2,599,433
Ensembl chrNW_004624795:2,595,072...2,599,077 		JBrowse link
G Mettl14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chrNW_004624867:5,508,847...5,533,395
Ensembl chrNW_004624867:5,508,886...5,533,395 		JBrowse link
G Minpp1 multiple inositol-polyphosphate phosphatase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624791:13,647,307...13,705,976
Ensembl chrNW_004624791:13,647,376...13,689,441 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24384392 NCBI chrNW_004624818:1,184,736...1,202,708
Ensembl chrNW_004624818:1,187,869...1,199,168 		JBrowse link
G N4bp2l2 NEDD4 binding protein 2 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624776:5,295,054...5,467,454 JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624831:195,552...200,458
Ensembl chrNW_004624831:191,625...200,860 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chrNW_004624937:564,191...584,470 JBrowse link
G Nr4a2 nuclear receptor subfamily 4 group A member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624732:9,572,160...9,589,624
Ensembl chrNW_004624732:9,581,779...9,589,942 		JBrowse link
G Pde4b phosphodiesterase 4B ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624742:28,557,159...29,113,269
Ensembl chrNW_004624742:28,557,283...29,016,844 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624762:9,328,275...9,382,996
Ensembl chrNW_004624762:9,328,109...9,386,067 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624775:1,092,018...1,173,848
Ensembl chrNW_004624775:1,145,797...1,169,858 		JBrowse link
G Pias1 protein inhibitor of activated STAT 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624781:4,893,308...5,046,928
Ensembl chrNW_004624781:4,893,308...5,046,582 		JBrowse link
G Pnp purine nucleoside phosphorylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18414634 NCBI chrNW_004624825:4,688,662...4,699,912
Ensembl chrNW_004624825:4,690,831...4,700,717 		JBrowse link
G Ptx3 pentraxin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624730:35,125,536...35,131,645
Ensembl chrNW_004624730:35,125,605...35,131,367 		JBrowse link
G Rfx3 regulatory factor X3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624736:8,001,078...8,301,856
Ensembl chrNW_004624736:8,003,234...8,161,150 		JBrowse link
G Rgs1 regulator of G protein signaling 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624814:1,041,812...1,045,961
Ensembl chrNW_004624814:1,041,784...1,045,954 		JBrowse link
G Rnf20 ring finger protein 20 ISO protein:increased expression:urine (human) RGD PMID:21136906 RGD:9831407 NCBI chrNW_004624758:9,759,535...9,783,235
Ensembl chrNW_004624758:9,758,101...9,783,411 		JBrowse link
G Rufy3 RUN and FYVE domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624890:2,032,980...2,135,922
Ensembl chrNW_004624890:2,032,995...2,134,648 		JBrowse link
G Sfpq splicing factor proline and glutamine rich ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624764:18,223,845...18,239,748
Ensembl chrNW_004624764:18,228,365...18,240,340 		JBrowse link
G Skil SKI like proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624730:48,376,625...48,404,059
Ensembl chrNW_004624730:48,377,499...48,404,141 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624855:3,260,800...3,271,864
Ensembl chrNW_004624855:3,260,809...3,271,367 		JBrowse link
G Sox18 SRY-box transcription factor 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624741:29,679,274...29,681,069
Ensembl chrNW_004624741:29,679,091...29,681,049 		JBrowse link
G Srp68 signal recognition particle 68 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624801:5,931,332...5,978,656
Ensembl chrNW_004624801:5,928,628...5,978,879 		JBrowse link
G Ssbp1 single stranded DNA binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624765:21,746,633...21,771,234
Ensembl chrNW_004624765:21,746,794...21,761,258 		JBrowse link
G Taf1d TATA-box binding protein associated factor, RNA polymerase I subunit D ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624735:38,397,922...38,407,255
Ensembl chrNW_004624735:38,402,356...38,405,172 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624866:5,706,483...5,758,666
Ensembl chrNW_004624866:5,706,850...5,728,771 		JBrowse link
G Tnik TRAF2 and NCK interacting kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624730:49,087,876...49,497,981
Ensembl chrNW_004624730:49,090,222...49,497,646 		JBrowse link
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18621066 PMID:19203779 NCBI chrNW_004624786:10,266,316...10,282,664
Ensembl chrNW_004624786:10,263,518...10,271,218 		JBrowse link
G Tra2a transformer 2 alpha homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624739:7,076,822...7,126,734
Ensembl chrNW_004624739:7,076,828...7,126,734 		JBrowse link
G Trappc10 trafficking protein particle complex subunit 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624745:29,959,237...30,031,074
Ensembl chrNW_004624745:29,961,054...30,031,113 		JBrowse link
G Uso1 USO1 vesicle transport factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624730:27,313...130,086
Ensembl chrNW_004624730:28,175...130,012 		JBrowse link
G Usp13 ubiquitin specific peptidase 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624730:57,384,878...57,495,761
Ensembl chrNW_004624730:57,384,884...57,495,765 		JBrowse link
G Zfand6 zinc finger AN1-type containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624941:953,407...1,025,082
Ensembl chrNW_004624941:967,345...1,027,018 		JBrowse link
G Znf331 zinc finger protein 331 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chrNW_004624832:2,667,646...2,677,690
Ensembl chrNW_004624832:2,667,198...2,690,390 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14092
    Chemically-Induced Disorders 1096
      Poisoning 582
        Arsenic Poisoning 59
Path 2
Term Annotations click to browse term
  disease 14092
    disease of anatomical entity 13771
      nervous system disease 12061
        toxic encephalopathy 177
          Heavy Metal Poisoning, Nervous System 76
            Arsenic Poisoning 59
paths to the root