Mettl14 (methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit) - Rat Genome Database

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Gene: Mettl14 (methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit) Heterocephalus glaber
Analyze
Symbol: Mettl14
Name: methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit (Ensembl:methyltransferase like 14)
RGD ID: 18922091
Description: ENCODES a protein that exhibits mRNA m(6)A methyltransferase activity (ortholog); S-adenosyl-L-methionine binding (ortholog); INVOLVED IN mRNA processing (ortholog); mRNA splicing, via spliceosome (ortholog); mRNA stabilization (ortholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); cardiomyopathy (ortholog); Cardiotoxicity (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); RNA N6-methyladenosine methyltransferase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methyltransferase 14, N6-adenosine-methyltransferase subunit; methyltransferase like 14; Methyltransferase-like protein 14; N6-adenosine-methyltransferase subunit METTL14
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248675,508,886 - 5,533,395 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248675,508,847 - 5,533,395 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Mettl14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248675,508,886 - 5,533,395 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248675,508,847 - 5,533,395 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
METTL14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384118,685,392 - 118,715,430 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4118,685,392 - 118,715,433 (+)EnsemblGRCh38hg38GRCh38
GRCh374119,606,547 - 119,636,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364119,826,022 - 119,851,538 (+)NCBINCBI36Build 36hg18NCBI36
Celera4116,967,249 - 116,992,643 (+)NCBICelera
Cytogenetic Map4q26NCBI
HuRef4115,328,317 - 115,353,645 (+)NCBIHuRef
CHM1_14119,582,519 - 119,608,035 (+)NCBICHM1_1
T2T-CHM13v2.04121,990,699 - 122,020,747 (+)NCBIT2T-CHM13v2.0
Mettl14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393123,161,944 - 123,179,639 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3123,161,946 - 123,179,757 (-)EnsemblGRCm39 Ensembl
GRCm383123,368,295 - 123,385,990 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3123,368,297 - 123,386,108 (-)EnsemblGRCm38mm10GRCm38
MGSCv373123,071,213 - 123,088,908 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363123,360,319 - 123,377,970 (-)NCBIMGSCv36mm8
Celera3129,790,343 - 129,808,044 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map353.96NCBI
Mettl14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82214,215,165 - 214,231,412 (-)NCBIGRCr8
mRatBN7.22211,530,598 - 211,546,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2211,530,602 - 211,546,821 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2219,202,456 - 219,218,700 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02217,102,330 - 217,118,574 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02211,956,574 - 211,972,818 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02227,566,811 - 227,583,047 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2227,566,815 - 227,582,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02246,923,967 - 246,940,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42220,100,824 - 220,116,567 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12220,063,883 - 220,079,920 (-)NCBI
Celera2203,944,258 - 203,960,057 (-)NCBICelera
Cytogenetic Map2q42NCBI
Mettl14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542821,475,981 - 21,507,730 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542821,475,981 - 21,507,730 (-)NCBIChiLan1.0ChiLan1.0
METTL14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23116,467,831 - 116,493,884 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14116,764,585 - 116,791,448 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04110,879,137 - 110,905,131 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14121,431,026 - 121,458,392 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4121,431,026 - 121,458,392 (+)Ensemblpanpan1.1panPan2
METTL14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13237,653,163 - 37,679,577 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3237,653,035 - 37,678,398 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha324,395,329 - 4,421,830 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03237,874,325 - 37,900,828 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3237,874,340 - 37,900,812 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13237,896,775 - 37,923,279 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03237,620,069 - 37,646,570 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0322,154,427 - 2,180,939 (-)NCBIUU_Cfam_GSD_1.0
Mettl14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530167,698,472 - 67,771,356 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936869568,840 - 590,269 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936869568,324 - 589,972 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METTL14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8105,015,420 - 105,053,563 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18105,019,539 - 105,053,603 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28112,710,190 - 112,744,393 (-)NCBISscrofa10.2Sscrofa10.2susScr3
METTL14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1766,169,080 - 66,195,324 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl766,168,855 - 66,194,121 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603745,007,010 - 45,033,195 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000019839   ⟹   ENSHGLP00000019643
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248675,508,886 - 5,533,395 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000019840   ⟹   ENSHGLP00000019644
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248675,509,026 - 5,530,176 (+)Ensembl
RefSeq Acc Id: XM_004870039   ⟹   XP_004870096
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248675,508,847 - 5,533,395 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004870096 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB06847 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000019643
  ENSHGLP00100010318
GenBank Protein JAO02877 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004870096   ⟸   XM_004870039
- UniProtKB: G5BC36 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000019643   ⟸   ENSHGLT00000019839
Ensembl Acc Id: ENSHGLP00000019644   ⟸   ENSHGLT00000019840


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014068 Ensembl, ENTREZGENE
  ENSHGLG00100007671 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000019839 ENTREZGENE
  ENSHGLT00100010442 UniProtKB/TrEMBL
InterPro METTL14-like UniProtKB/TrEMBL
  MT-A70-like UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
KEGG Report hgl:101708897 UniProtKB/TrEMBL
NCBI Gene Mettl14 ENTREZGENE
PANTHER N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT UniProtKB/TrEMBL
  PTHR13107 UniProtKB/TrEMBL
Pfam MT-A70 UniProtKB/TrEMBL
PROSITE MT_A70 UniProtKB/TrEMBL
  SAM_MTA70L_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt G5BC36 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-19 Mettl14  methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit  Mettl14  methyltransferase 14, N6-adenosine-methyltransferase subunit  Symbol and/or name change 5135510 APPROVED
2021-05-26 Mettl14  methyltransferase 14, N6-adenosine-methyltransferase subunit  Mettl14  methyltransferase like 14  Symbol and/or name change 5135510 APPROVED