METTL14 (methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit) - Rat Genome Database

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Gene: METTL14 (methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit) Homo sapiens
Analyze
Symbol: METTL14
Name: methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit (Ensembl:methyltransferase 14, N6-adenosine-methyltransferase subunit)
RGD ID: 1605646
HGNC Page HGNC:29330
Description: Enables mRNA binding activity and mRNA m(6)A methyltransferase activity. Involved in mRNA splicing, via spliceosome; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of translation. Located in nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hMETTL14; KIAA1627; methyltransferase 14, N6-adenosine-methyltransferase subunit; methyltransferase like 14; methyltransferase-like protein 14; N6-adenosine-methyltransferase non-catalytic subunit; N6-adenosine-methyltransferase subunit METTL14
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384118,685,392 - 118,715,430 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4118,685,392 - 118,715,433 (+)EnsemblGRCh38hg38GRCh38
GRCh374119,606,547 - 119,636,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364119,826,022 - 119,851,538 (+)NCBINCBI36Build 36hg18NCBI36
Celera4116,967,249 - 116,992,643 (+)NCBICelera
Cytogenetic Map4q26NCBI
HuRef4115,328,317 - 115,353,645 (+)NCBIHuRef
CHM1_14119,582,519 - 119,608,035 (+)NCBICHM1_1
T2T-CHM13v2.04121,990,699 - 122,020,747 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IDA,TAS)
nucleus  (IBA,IDA,IEA,NAS)
RNA N6-methyladenosine methyltransferase complex  (IBA,IDA,IEA,IPI)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury. Yu J, etal., Mol Brain. 2020 Jan 28;13(1):11. doi: 10.1186/s13041-020-0554-0.
Additional References at PubMed
PMID:10997877   PMID:12477932   PMID:14702039   PMID:17207965   PMID:20332099   PMID:21873635   PMID:22939629   PMID:24316715   PMID:24394384   PMID:24981863   PMID:25231264   PMID:25719671  
PMID:26344197   PMID:26458103   PMID:26496610   PMID:27281194   PMID:27373337   PMID:27627798   PMID:28247949   PMID:28712289   PMID:29290617   PMID:29348140   PMID:29395067   PMID:29489750  
PMID:29506078   PMID:29507755   PMID:30006613   PMID:30232453   PMID:30306128   PMID:30554943   PMID:31226160   PMID:31318098   PMID:31527615   PMID:31585521   PMID:31697949   PMID:31760940  
PMID:31976022   PMID:32097728   PMID:32111213   PMID:32323801   PMID:32333907   PMID:32416067   PMID:32513696   PMID:32552762   PMID:32576970   PMID:32583611   PMID:32633395   PMID:32813328  
PMID:32843065   PMID:32964498   PMID:33134390   PMID:33159022   PMID:33217317   PMID:33314339   PMID:33414476   PMID:33544495   PMID:33664855   PMID:33849617   PMID:33903120   PMID:33961781  
PMID:34097350   PMID:34131102   PMID:34133714   PMID:34225491   PMID:34332039   PMID:34373451   PMID:34412584   PMID:34503454   PMID:34586620   PMID:34586732   PMID:34609072   PMID:34624573  
PMID:34689367   PMID:34743822   PMID:34813676   PMID:34847358   PMID:34910686   PMID:35022519   PMID:35090245   PMID:35093098   PMID:35115038   PMID:35139773   PMID:35143475   PMID:35154166  
PMID:35156780   PMID:35164771   PMID:35235104   PMID:35249103   PMID:35305660   PMID:35356881   PMID:35467063   PMID:35538475   PMID:35543357   PMID:35583059   PMID:35597169   PMID:35598196  
PMID:35638109   PMID:35810559   PMID:35831314   PMID:35944360   PMID:35974338   PMID:35980318   PMID:36215168   PMID:36352154   PMID:36448247   PMID:36526897   PMID:36569923   PMID:36597993  
PMID:36810285   PMID:37017680   PMID:37076497   PMID:37195267   PMID:37309980   PMID:37534933   PMID:37539726   PMID:37543013   PMID:37594665   PMID:37615536   PMID:37741915   PMID:37957146  
PMID:37972448   PMID:37973560   PMID:38131226   PMID:38146129   PMID:38195017   PMID:38197667   PMID:38229320   PMID:38319733   PMID:38387756   PMID:38403332   PMID:38421707   PMID:38627387  


Genomics

Comparative Map Data
METTL14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384118,685,392 - 118,715,430 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4118,685,392 - 118,715,433 (+)EnsemblGRCh38hg38GRCh38
GRCh374119,606,547 - 119,636,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364119,826,022 - 119,851,538 (+)NCBINCBI36Build 36hg18NCBI36
Celera4116,967,249 - 116,992,643 (+)NCBICelera
Cytogenetic Map4q26NCBI
HuRef4115,328,317 - 115,353,645 (+)NCBIHuRef
CHM1_14119,582,519 - 119,608,035 (+)NCBICHM1_1
T2T-CHM13v2.04121,990,699 - 122,020,747 (+)NCBIT2T-CHM13v2.0
Mettl14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393123,161,944 - 123,179,639 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3123,161,946 - 123,179,757 (-)EnsemblGRCm39 Ensembl
GRCm383123,368,295 - 123,385,990 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3123,368,297 - 123,386,108 (-)EnsemblGRCm38mm10GRCm38
MGSCv373123,071,213 - 123,088,908 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363123,360,319 - 123,377,970 (-)NCBIMGSCv36mm8
Celera3129,790,343 - 129,808,044 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map353.96NCBI
Mettl14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82214,215,165 - 214,231,412 (-)NCBIGRCr8
mRatBN7.22211,530,598 - 211,546,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2211,530,602 - 211,546,821 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2219,202,456 - 219,218,700 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02217,102,330 - 217,118,574 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02211,956,574 - 211,972,818 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02227,566,811 - 227,583,047 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2227,566,815 - 227,582,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02246,923,967 - 246,940,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42220,100,824 - 220,116,567 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12220,063,883 - 220,079,920 (-)NCBI
Celera2203,944,258 - 203,960,057 (-)NCBICelera
Cytogenetic Map2q42NCBI
Mettl14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542821,475,981 - 21,507,730 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542821,475,981 - 21,507,730 (-)NCBIChiLan1.0ChiLan1.0
METTL14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23116,467,831 - 116,493,884 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14116,764,585 - 116,791,448 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04110,879,137 - 110,905,131 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14121,431,026 - 121,458,392 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4121,431,026 - 121,458,392 (+)Ensemblpanpan1.1panPan2
METTL14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13237,653,163 - 37,679,577 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3237,653,035 - 37,678,398 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha324,395,329 - 4,421,830 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03237,874,325 - 37,900,828 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3237,874,340 - 37,900,812 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13237,896,775 - 37,923,279 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03237,620,069 - 37,646,570 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0322,154,427 - 2,180,939 (-)NCBIUU_Cfam_GSD_1.0
Mettl14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530167,698,472 - 67,771,356 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936869568,840 - 590,269 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936869568,324 - 589,972 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METTL14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8105,015,420 - 105,053,563 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18105,019,539 - 105,053,603 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28112,710,190 - 112,744,393 (-)NCBISscrofa10.2Sscrofa10.2susScr3
METTL14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1766,169,080 - 66,195,324 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl766,168,855 - 66,194,121 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603745,007,010 - 45,033,195 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mettl14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248675,508,886 - 5,533,395 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248675,508,847 - 5,533,395 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in METTL14
8 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q26-35.2(chr4:118065569-190042639)x3 copy number gain See cases [RCV000051785] Chr4:118065569..190042639 [GRCh38]
Chr4:118986724..190828225 [GRCh37]
Chr4:119206172..191200788 [NCBI36]
Chr4:4q26-35.2		 pathogenic
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3		 pathogenic
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
Chr4:4q22.3-28.3		 pathogenic
GRCh38/hg38 4q26-31.21(chr4:116630862-145429900)x1 copy number loss See cases [RCV000053321] Chr4:116630862..145429900 [GRCh38]
Chr4:117552018..146351052 [GRCh37]
Chr4:117771466..146570502 [NCBI36]
Chr4:4q26-31.21		 pathogenic
GRCh38/hg38 4q26-27(chr4:118360303-120924156)x1 copy number loss See cases [RCV000138837] Chr4:118360303..120924156 [GRCh38]
Chr4:119281458..121845311 [GRCh37]
Chr4:119500906..122064761 [NCBI36]
Chr4:4q26-27		 pathogenic
GRCh38/hg38 4q26(chr4:116090996-119545165)x1 copy number loss See cases [RCV000138236] Chr4:116090996..119545165 [GRCh38]
Chr4:117012152..120466320 [GRCh37]
Chr4:117231601..120685768 [NCBI36]
Chr4:4q26		 likely pathogenic
GRCh38/hg38 4q26-28.3(chr4:117351881-133565667)x1 copy number loss See cases [RCV000143207] Chr4:117351881..133565667 [GRCh38]
Chr4:118273037..134486822 [GRCh37]
Chr4:118492485..134706272 [NCBI36]
Chr4:4q26-28.3		 pathogenic
GRCh37/hg19 4q26-35.2(chr4:119437495-190904301)x3 copy number gain See cases [RCV000240392] Chr4:119437495..190904301 [GRCh37]
Chr4:4q26-35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q25-35.2(chr4:109199664-189752726)x3 copy number gain See cases [RCV000511945] Chr4:109199664..189752726 [GRCh37]
Chr4:4q25-35.2		 pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2		 pathogenic
NM_020961.4(METTL14):c.581C>T (p.Pro194Leu) single nucleotide variant not specified [RCV004320811] Chr4:118697259 [GRCh38]
Chr4:119618414 [GRCh37]
Chr4:4q26		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q26-28.2(chr4:116307857-129302960)x1 copy number loss not provided [RCV000682448] Chr4:116307857..129302960 [GRCh37]
Chr4:4q26-28.2		 pathogenic
GRCh37/hg19 4q26(chr4:117108352-120317108)x1 copy number loss not provided [RCV000682449] Chr4:117108352..120317108 [GRCh37]
Chr4:4q26		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787448] Chr4:116624547..126168646 [GRCh37]
Chr4:4q26-28.1		 likely pathogenic
GRCh37/hg19 4q26(chr4:119410381-119730068)x3 copy number gain not provided [RCV000848185] Chr4:119410381..119730068 [GRCh37]
Chr4:4q26		 uncertain significance
GRCh37/hg19 4q26-28.2(chr4:116833638-130232122) copy number loss Atypical behavior [RCV001352657] Chr4:116833638..130232122 [GRCh37]
Chr4:4q26-28.2		 pathogenic
GRCh37/hg19 4q26-28.3(chr4:114872547-138005267)x1 copy number loss not provided [RCV001795851] Chr4:114872547..138005267 [GRCh37]
Chr4:4q26-28.3		 pathogenic
GRCh37/hg19 4q26-28.2(chr4:116888785-129649979) copy number loss not specified [RCV002053451] Chr4:116888785..129649979 [GRCh37]
Chr4:4q26-28.2		 pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21		 pathogenic
GRCh37/hg19 4q24-31.21(chr4:104715235-145252595) copy number gain not specified [RCV002053446] Chr4:104715235..145252595 [GRCh37]
Chr4:4q24-31.21		 pathogenic
NM_020961.4(METTL14):c.1294T>A (p.Ser432Thr) single nucleotide variant not specified [RCV004202370] Chr4:118710225 [GRCh38]
Chr4:119631380 [GRCh37]
Chr4:4q26		 uncertain significance
NM_020961.4(METTL14):c.562G>A (p.Val188Met) single nucleotide variant not specified [RCV004143294] Chr4:118697240 [GRCh38]
Chr4:119618395 [GRCh37]
Chr4:4q26		 uncertain significance
NM_020961.4(METTL14):c.904G>A (p.Gly302Arg) single nucleotide variant not specified [RCV004115895] Chr4:118705659 [GRCh38]
Chr4:119626814 [GRCh37]
Chr4:4q26		 uncertain significance
NM_020961.4(METTL14):c.80G>A (p.Ser27Asn) single nucleotide variant not specified [RCV004179918] Chr4:118687936 [GRCh38]
Chr4:119609091 [GRCh37]
Chr4:4q26		 uncertain significance
NM_020961.4(METTL14):c.284A>G (p.Tyr95Cys) single nucleotide variant not specified [RCV004112955] Chr4:118691572 [GRCh38]
Chr4:119612727 [GRCh37]
Chr4:4q26		 uncertain significance
NM_020961.4(METTL14):c.691A>G (p.Ile231Val) single nucleotide variant not specified [RCV004334664] Chr4:118700595 [GRCh38]
Chr4:119621750 [GRCh37]
Chr4:4q26		 uncertain significance
GRCh37/hg19 4q26-32.3(chr4:117518683-168174703)x3 copy number gain not provided [RCV003484198] Chr4:117518683..168174703 [GRCh37]
Chr4:4q26-32.3		 pathogenic
NM_020961.4(METTL14):c.903C>T (p.Asp301=) single nucleotide variant not provided [RCV003439480] Chr4:118705658 [GRCh38]
Chr4:119626813 [GRCh37]
Chr4:4q26		 likely benign
GRCh37/hg19 4q24-35.2(chr4:101203509-190957473)x3 copy number gain not specified [RCV003986496] Chr4:101203509..190957473 [GRCh37]
Chr4:4q24-35.2		 pathogenic
NM_020961.4(METTL14):c.268G>C (p.Glu90Gln) single nucleotide variant not specified [RCV004424296] Chr4:118691556 [GRCh38]
Chr4:119612711 [GRCh37]
Chr4:4q26		 uncertain significance
GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3 copy number gain not provided [RCV003885507] Chr4:45455621..191003541 [GRCh37]
Chr4:4p12-q35.2		 pathogenic
NM_020961.4(METTL14):c.1027C>T (p.Arg343Cys) single nucleotide variant not specified [RCV004424294] Chr4:118705782 [GRCh38]
Chr4:119626937 [GRCh37]
Chr4:4q26		 uncertain significance
NM_020961.4(METTL14):c.1331G>T (p.Gly444Val) single nucleotide variant not specified [RCV004424295] Chr4:118710262 [GRCh38]
Chr4:119631417 [GRCh37]
Chr4:4q26		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1665
Count of miRNA genes:812
Interacting mature miRNAs:940
Transcripts:ENST00000388822, ENST00000502564, ENST00000506780, ENST00000508801
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-50843  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374119,623,085 - 119,623,178UniSTSGRCh37
Build 364119,842,533 - 119,842,626RGDNCBI36
Celera4116,983,635 - 116,983,728RGD
Cytogenetic Map4q26UniSTS
HuRef4115,344,646 - 115,344,739UniSTS
SHGC-24254  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374119,623,036 - 119,623,127UniSTSGRCh37
Build 364119,842,484 - 119,842,575RGDNCBI36
Celera4116,983,586 - 116,983,677RGD
Cytogenetic Map4q26UniSTS
HuRef4115,344,597 - 115,344,688UniSTS
SHGC-7036  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374119,623,038 - 119,623,138UniSTSGRCh37
Build 364119,842,486 - 119,842,586RGDNCBI36
Celera4116,983,588 - 116,983,688RGD
Cytogenetic Map4q26UniSTS
HuRef4115,344,599 - 115,344,699UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 269 270 269 54 756 56 913 101 592 148 837 428 10 1 96 523 5 1
Low 2170 2651 1457 570 1133 409 3444 2088 3142 270 623 1185 165 1108 2265 1 1
Below cutoff 70 62 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000388822   ⟹   ENSP00000373474
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4118,685,392 - 118,715,430 (+)Ensembl
RefSeq Acc Id: ENST00000502564
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4118,691,534 - 118,697,355 (+)Ensembl
RefSeq Acc Id: ENST00000506780   ⟹   ENSP00000424111
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4118,697,211 - 118,710,601 (+)Ensembl
RefSeq Acc Id: ENST00000508801   ⟹   ENSP00000425460
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4118,685,415 - 118,689,429 (+)Ensembl
RefSeq Acc Id: ENST00000626212   ⟹   ENSP00000486381
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4118,685,400 - 118,694,463 (+)Ensembl
RefSeq Acc Id: ENST00000628452   ⟹   ENSP00000486933
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4118,685,413 - 118,715,433 (+)Ensembl
RefSeq Acc Id: NM_020961   ⟹   NP_066012
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384118,685,392 - 118,715,430 (+)NCBI
GRCh374119,606,525 - 119,633,374 (+)NCBI
Build 364119,826,022 - 119,851,538 (+)NCBI Archive
Celera4116,967,249 - 116,992,643 (+)RGD
HuRef4115,328,317 - 115,353,645 (+)RGD
CHM1_14119,582,470 - 119,609,370 (+)NCBI
T2T-CHM13v2.04121,990,699 - 122,020,747 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047416029   ⟹   XP_047271985
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384118,685,392 - 118,705,709 (+)NCBI
RefSeq Acc Id: XM_054350631   ⟹   XP_054206606
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04121,990,699 - 122,011,026 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_066012   ⟸   NM_020961
- UniProtKB: A6NIG1 (UniProtKB/Swiss-Prot),   Q969V2 (UniProtKB/Swiss-Prot),   Q9HCE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000424111   ⟸   ENST00000506780
RefSeq Acc Id: ENSP00000373474   ⟸   ENST00000388822
RefSeq Acc Id: ENSP00000425460   ⟸   ENST00000508801
RefSeq Acc Id: ENSP00000486381   ⟸   ENST00000626212
RefSeq Acc Id: ENSP00000486933   ⟸   ENST00000628452
RefSeq Acc Id: XP_047271985   ⟸   XM_047416029
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054206606   ⟸   XM_054350631
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9HCE5-F1-model_v2 AlphaFold Q9HCE5 1-456 view protein structure

Promoters
RGD ID:6868500
Promoter ID:EPDNEW_H7336
Type:initiation region
Name:METTL14_1
Description:methyltransferase like 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384118,685,393 - 118,685,453EPDNEW
RGD ID:6802412
Promoter ID:HG_KWN:48984
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid
Transcripts:ENST00000388822,   UC003ICG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364119,825,784 - 119,826,284 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:29330 AgrOrtholog
COSMIC METTL14 COSMIC
Ensembl Genes ENSG00000145388 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000388822 ENTREZGENE
  ENST00000388822.10 UniProtKB/Swiss-Prot
  ENST00000506780.2 UniProtKB/TrEMBL
  ENST00000508801.1 UniProtKB/TrEMBL
  ENST00000626212.2 UniProtKB/TrEMBL
  ENST00000628452.2 UniProtKB/TrEMBL
GTEx ENSG00000145388 GTEx
HGNC ID HGNC:29330 ENTREZGENE
Human Proteome Map METTL14 Human Proteome Map
InterPro METTL14-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MT-A70-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot
KEGG Report hsa:57721 UniProtKB/Swiss-Prot
NCBI Gene 57721 ENTREZGENE
OMIM 616504 OMIM
PANTHER N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13107 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MT-A70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA164722277 PharmGKB
PROSITE MT_A70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_MTA70L_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot
UniProt A0A0D9SF88_HUMAN UniProtKB/TrEMBL
  A0A0D9SFW0_HUMAN UniProtKB/TrEMBL
  A6NIG1 ENTREZGENE
  D6RBL4_HUMAN UniProtKB/TrEMBL
  D6RD73_HUMAN UniProtKB/TrEMBL
  MET14_HUMAN UniProtKB/Swiss-Prot
  Q969V2 ENTREZGENE
  Q9HCE5 ENTREZGENE
UniProt Secondary A6NIG1 UniProtKB/Swiss-Prot
  Q969V2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-18 METTL14  methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit  METTL14  methyltransferase 14, N6-adenosine-methyltransferase subunit  Symbol and/or name change 19259463 PROVISIONAL
2021-05-24 METTL14  methyltransferase 14, N6-adenosine-methyltransferase subunit  METTL14  methyltransferase like 14  Symbol and/or name change 19259463 PROVISIONAL