METTL14 (methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit) - Rat Genome Database

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Gene: METTL14 (methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit) Chlorocebus sabaeus
Analyze
Symbol: METTL14
Name: methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit (Ensembl:methyltransferase 14, N6-adenosine-methyltransferase subunit)
RGD ID: 18710928
Description: ENCODES a protein that exhibits mRNA m(6)A methyltransferase activity (ortholog); S-adenosyl-L-methionine binding (ortholog); INVOLVED IN mRNA modification (ortholog); response to nutrient levels (ortholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); cardiomyopathy (ortholog); Cardiotoxicity (ortholog); FOUND IN nucleus (ortholog); RNA N6-methyladenosine methyltransferase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methyltransferase 14, N6-adenosine-methyltransferase subunit; methyltransferase like 14; N6-adenosine-methyltransferase non-catalytic subunit; N6-adenosine-methyltransferase subunit METTL14
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1766,169,080 - 66,195,324 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl766,168,855 - 66,194,121 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603745,007,010 - 45,033,195 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
METTL14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1766,169,080 - 66,195,324 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl766,168,855 - 66,194,121 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603745,007,010 - 45,033,195 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
METTL14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384118,685,392 - 118,715,430 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4118,685,392 - 118,715,433 (+)EnsemblGRCh38hg38GRCh38
GRCh374119,606,547 - 119,636,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364119,826,022 - 119,851,538 (+)NCBINCBI36Build 36hg18NCBI36
Celera4116,967,249 - 116,992,643 (+)NCBICelera
Cytogenetic Map4q26NCBI
HuRef4115,328,317 - 115,353,645 (+)NCBIHuRef
CHM1_14119,582,519 - 119,608,035 (+)NCBICHM1_1
T2T-CHM13v2.04121,990,699 - 122,020,747 (+)NCBIT2T-CHM13v2.0
Mettl14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393123,161,944 - 123,179,639 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3123,161,946 - 123,179,757 (-)EnsemblGRCm39 Ensembl
GRCm383123,368,295 - 123,385,990 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3123,368,297 - 123,386,108 (-)EnsemblGRCm38mm10GRCm38
MGSCv373123,071,213 - 123,088,908 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363123,360,319 - 123,377,970 (-)NCBIMGSCv36mm8
Celera3129,790,343 - 129,808,044 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map353.96NCBI
Mettl14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82214,215,165 - 214,231,412 (-)NCBIGRCr8
mRatBN7.22211,530,598 - 211,546,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2211,530,602 - 211,546,821 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2219,202,456 - 219,218,700 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02217,102,330 - 217,118,574 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02211,956,574 - 211,972,818 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02227,566,811 - 227,583,047 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2227,566,815 - 227,582,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02246,923,967 - 246,940,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42220,100,824 - 220,116,567 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12220,063,883 - 220,079,920 (-)NCBI
Celera2203,944,258 - 203,960,057 (-)NCBICelera
Cytogenetic Map2q42NCBI
Mettl14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542821,475,981 - 21,507,730 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542821,475,981 - 21,507,730 (-)NCBIChiLan1.0ChiLan1.0
METTL14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23116,467,831 - 116,493,884 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14116,764,585 - 116,791,448 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04110,879,137 - 110,905,131 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14121,431,026 - 121,458,392 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4121,431,026 - 121,458,392 (+)Ensemblpanpan1.1panPan2
METTL14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13237,653,163 - 37,679,577 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3237,653,035 - 37,678,398 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha324,395,329 - 4,421,830 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03237,874,325 - 37,900,828 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3237,874,340 - 37,900,812 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13237,896,775 - 37,923,279 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03237,620,069 - 37,646,570 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0322,154,427 - 2,180,939 (-)NCBIUU_Cfam_GSD_1.0
Mettl14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530167,698,472 - 67,771,356 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936869568,840 - 590,269 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936869568,324 - 589,972 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METTL14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8105,015,420 - 105,053,563 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18105,019,539 - 105,053,603 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28112,710,190 - 112,744,393 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Mettl14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248675,508,886 - 5,533,395 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248675,508,847 - 5,533,395 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 32 38
Low 4 20 22
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007999653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000001792   ⟹   ENSCSAP00000000132
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl766,168,855 - 66,194,121 (+)Ensembl
RefSeq Acc Id: XM_007999653   ⟹   XP_007997844
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1766,169,080 - 66,195,324 (+)NCBI
Vero_WHO_p1.0NW_02366603745,007,010 - 45,033,195 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007997844 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000000132
  ENSCSAP00000000132.1
Reference Protein Sequences
RefSeq Acc Id: XP_007997844   ⟸   XM_007999653
- UniProtKB: A0A0D9QUU3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000000132   ⟸   ENSCSAT00000001792


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003762 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001792.1 UniProtKB/TrEMBL
InterPro METTL14-like UniProtKB/TrEMBL
  MT-A70-like UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
KEGG Report csab:103236171 UniProtKB/TrEMBL
NCBI Gene METTL14 ENTREZGENE
PANTHER N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT UniProtKB/TrEMBL
  PTHR13107 UniProtKB/TrEMBL
Pfam MT-A70 UniProtKB/TrEMBL
PROSITE MT_A70 UniProtKB/TrEMBL
  SAM_MTA70L_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A0D9QUU3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-19 METTL14  methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit  METTL14  methyltransferase 14, N6-adenosine-methyltransferase subunit  Symbol and/or name change 5135510 APPROVED
2021-05-26 METTL14  methyltransferase 14, N6-adenosine-methyltransferase subunit  METTL14  methyltransferase like 14  Symbol and/or name change 5135510 APPROVED