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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Abdominal Obesity
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Accession:DOID:9007772 term browser browse the term
Definition:A condition of having excess fat in the abdomen. Abdominal obesity is typically defined as waist circumferences of 40 inches or more in men and 35 inches or more in women. Abdominal obesity raises the risk of developing disorders, such as diabetes, hypertension and METABOLIC SYNDROME X.
Synonyms:exact_synonym: Abdominal Obesities;   Central Obesities;   Central Obesity;   Visceral Obesities;   Visceral Obesity
 primary_id: MESH:D056128
 alt_id: RDO:0007735

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show annotations for term's descendants           Sort by:
Abdominal Obesity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD163 CD163 molecule exacerbates ISO protein:increased expression:blood serum (human) RGD PMID:31027316 RGD:127345132 NCBI chr11:7,501,562...7,536,332
Ensembl chr11:7,501,150...7,536,295 		JBrowse link
G CYP2R1 cytochrome P450 family 2 subfamily R member 1 ISO DNA:SNP:CDS: rs12794714 (human) RGD PMID:34906413 RGD:401900724 NCBI chr 1:50,030,366...50,043,833
Ensembl chr 1:50,031,218...50,047,403 		JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15199296 NCBI chr25:19,720,096...19,772,806
Ensembl chr25:19,719,848...19,750,200 		JBrowse link
abdominal obesity-metabolic syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCY2C guanylate cyclase 2C ISO MouseDO NCBI chr11:14,534,787...14,668,746
Ensembl chr11:14,534,883...14,613,255 		JBrowse link
G LEP leptin ISO MouseDO NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220 		JBrowse link
G LOC103231119 cardiotrophin-1 ISO MouseDO NCBI chr 5:27,579,175...27,586,779
Ensembl chr 5:27,579,987...27,585,759 		JBrowse link
G NEIL1 nei like DNA glycosylase 1 ISO MouseDO NCBI chr26:8,074,706...8,082,437
Ensembl chr26:8,074,310...8,082,123 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15309680
G PPARG peroxisome proliferator activated receptor gamma ISO MouseDO NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha ISO mRNA:increased expression:gastrocnemius muscle (rat) RGD PMID:23320128 RGD:7241841 NCBI chr27:25,882,385...26,563,530
Ensembl chr27:26,465,499...26,564,582 		JBrowse link
G PRKCI protein kinase C iota ISO MouseDO NCBI chr15:19,103,682...19,180,689 JBrowse link
G SIRT3 sirtuin 3 ISO MouseDO NCBI chr 1:25,740...49,471
Ensembl chr 1:26,927...48,944 		JBrowse link
G SLC2A9 solute carrier family 2 member 9 ISO MouseDO NCBI chr27:40,030,051...40,224,069 JBrowse link
abdominal obesity-metabolic syndrome 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO protein:increased oxidation:cardiac muscle cell RGD PMID:23997093 RGD:13782087 NCBI chr11:105,522,175...105,590,291
Ensembl chr11:105,522,157...105,590,958 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chr 6:42,186,028...42,193,105 JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895 		JBrowse link
G FADD Fas associated via death domain treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chr 1:4,358,314...4,361,863 JBrowse link
G LEP leptin ISO OMIM:605552 MouseDO NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220 		JBrowse link
G LPL lipoprotein lipase treatment ISO RGD PMID:26996629 RGD:13794382 NCBI chr 8:18,009,049...18,038,315
Ensembl chr 8:18,009,093...18,038,598 		JBrowse link
G MTTP microsomal triglyceride transfer protein ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 1 ClinVar PMID:8533758 PMID:9671739 PMID:16199547 PMID:16721486 PMID:21394827 More... NCBI chr 7:47,706,591...47,765,154
Ensembl chr 7:47,717,089...47,765,149 		JBrowse link
G TLR2 toll like receptor 2 susceptibility ISO RGD PMID:19841034 RGD:15090861 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TP53INP1 tumor protein p53 inducible nuclear protein 1 ISO OMIM:605552 MouseDO NCBI chr 8:89,893,531...89,918,054
Ensembl chr 8:89,893,419...89,908,228 		JBrowse link
abdominal obesity-metabolic syndrome 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHDC1 AT-hook DNA binding motif containing 1 ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 3 ClinVar PMID:25741868 PMID:29696776 PMID:33644933 NCBI chr20:105,187,943...105,257,767
Ensembl chr20:105,239,747...105,244,558 		JBrowse link
G LOC103234688 dual specificity tyrosine-phosphorylation-regulated kinase 1B ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 3 | ClinVar Annotator: match by term: DYRK1B-related condition OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:24827035 PMID:25741868 PMID:28492532 More... NCBI chr 6:34,361,467...34,370,292
Ensembl chr 6:34,357,449...34,368,067 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15342
    Nutritional and Metabolic Diseases 7357
      nutrition disease 802
        overnutrition 593
          obesity 593
            Abdominal Obesity 23
              abdominal obesity-metabolic syndrome + 20
Path 2
Term Annotations click to browse term
  disease 15342
    Nutritional and Metabolic Diseases 7357
      disease of metabolism 7357
        acquired metabolic disease 2205
          nutrition disease 802
            overnutrition 593
              obesity 593
                Abdominal Obesity 23
                  abdominal obesity-metabolic syndrome + 20
paths to the root