LOC103234688 (dual specificity tyrosine-phosphorylation-regulated kinase 1B) - Rat Genome Database

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Gene: LOC103234688 (dual specificity tyrosine-phosphorylation-regulated kinase 1B) Chlorocebus sabaeus
Analyze
Symbol: LOC103234688 (Ensembl: DYRK1B)
Name: dual specificity tyrosine-phosphorylation-regulated kinase 1B (Ensembl:dual specificity tyrosine phosphorylation regulated kinase 1B)
RGD ID: 18671987
Description: ENCODES a protein that exhibits ATP binding (inferred); nucleotide binding (inferred); protein kinase activity (inferred); INVOLVED IN myoblast fusion (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome 3 (ortholog); Carpenter Syndrome 2 (ortholog); congenital hypoplastic anemia (ortholog); FOUND IN chromosome (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity tyrosine phosphorylation regulated kinase 1B; DYRK1B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,361,467 - 34,370,292 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,357,449 - 34,368,067 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,435,577 - 12,444,444 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC103234688
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,361,467 - 34,370,292 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,357,449 - 34,368,067 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,435,577 - 12,444,444 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DYRK1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,825,350 - 39,834,162 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,825,350 - 39,834,201 (-)EnsemblGRCh38hg38GRCh38
GRCh371940,315,990 - 40,324,802 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,007,830 - 45,016,681 (-)NCBINCBI36Build 36hg18NCBI36
Build 341945,007,830 - 45,016,681NCBI
Celera1937,118,283 - 37,127,135 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,763,002 - 36,771,854 (-)NCBIHuRef
CHM1_11940,317,337 - 40,326,189 (-)NCBICHM1_1
T2T-CHM13v2.01942,630,272 - 42,639,084 (-)NCBIT2T-CHM13v2.0
Dyrk1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,878,880 - 27,896,896 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,878,894 - 27,886,719 (+)EnsemblGRCm39 Ensembl
GRCm38728,179,447 - 28,197,910 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,179,469 - 28,187,294 (+)EnsemblGRCm38mm10GRCm38
MGSCv37728,964,502 - 28,972,313 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36727,888,243 - 27,896,054 (+)NCBIMGSCv36mm8
Celera722,740,702 - 22,748,513 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.67NCBI
Dyrk1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,606,743 - 92,624,089 (+)NCBIGRCr8
mRatBN7.2183,479,168 - 83,497,011 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,479,147 - 83,487,169 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,889,379 - 88,897,399 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,347,612 - 97,355,624 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,645,238 - 90,653,258 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,112,819 - 85,120,840 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,112,247 - 85,120,839 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,329,130 - 86,336,572 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,281,284 - 83,288,783 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,359,284 - 83,366,556 (+)NCBI
Celera177,879,060 - 77,887,106 (+)NCBICelera
Cytogenetic Map1q21NCBI
Dyrk1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555781,187,742 - 1,195,574 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555781,187,128 - 1,195,574 (+)NCBIChiLan1.0ChiLan1.0
DYRK1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22046,054,312 - 46,062,601 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,924,968 - 47,933,257 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,857,223 - 36,866,099 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,405,063 - 45,411,483 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,405,431 - 45,411,387 (-)Ensemblpanpan1.1panPan2
DYRK1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,644,191 - 113,652,441 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,644,100 - 113,828,488 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,048,229 - 113,056,478 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,244,782 - 114,253,047 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,244,830 - 114,253,033 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,802,615 - 113,810,861 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,436,276 - 113,444,515 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,430,538 - 114,438,787 (+)NCBIUU_Cfam_GSD_1.0
Dyrk1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,008,632 - 14,016,673 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,433,483 - 2,444,752 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,436,702 - 2,444,758 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYRK1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,305,849 - 48,314,514 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,305,837 - 48,314,523 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,172,231 - 44,180,912 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Dyrk1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462492546,748 - 55,481 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462492540,175 - 56,177 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20 29
Low 16 20 31
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000001816   ⟹   ENSCSAP00000000154
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl634,357,449 - 34,368,067 (-)Ensembl
RefSeq Acc Id: XM_007996797   ⟹   XP_007994988
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1634,361,467 - 34,370,096 (-)NCBI
Vero_WHO_p1.0NW_02366607312,435,577 - 12,444,178 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007996799   ⟹   XP_007994990
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1634,361,467 - 34,369,350 (-)NCBI
Vero_WHO_p1.0NW_02366607312,435,577 - 12,444,176 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007996800   ⟹   XP_007994991
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1634,361,467 - 34,370,292 (-)NCBI
Vero_WHO_p1.0NW_02366607312,435,577 - 12,444,444 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007996801   ⟹   XP_007994992
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1634,361,467 - 34,370,292 (-)NCBI
Vero_WHO_p1.0NW_02366607312,435,577 - 12,444,444 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007996802   ⟹   XP_007994993
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1634,361,467 - 34,370,292 (-)NCBI
Vero_WHO_p1.0NW_02366607312,435,577 - 12,444,444 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037991679   ⟹   XP_037847607
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607312,435,577 - 12,444,178 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007994993   ⟸   XM_007996802
- Peptide Label: isoform X6
- UniProtKB: A0A0D9QUW5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007994992   ⟸   XM_007996801
- Peptide Label: isoform X5
- UniProtKB: A0A0D9QUW5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007994991   ⟸   XM_007996800
- Peptide Label: isoform X4
- UniProtKB: A0A0D9QUW5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007994988   ⟸   XM_007996797
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QUW5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007994990   ⟸   XM_007996799
- Peptide Label: isoform X3
- UniProtKB: A0A0D9QUW5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000000154   ⟸   ENSCSAT00000001816
RefSeq Acc Id: XP_037847607   ⟸   XM_037991679
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QUW5 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003786 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001816.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  PKc_DYR1A/1B UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene DYRK1B ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN KINASE UniProtKB/TrEMBL
  PTHR24058:SF12 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9QUW5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-08 LOC103234688  dual specificity tyrosine-phosphorylation-regulated kinase 1B  DYRK1B  dual specificity tyrosine phosphorylation regulated kinase 1B  Symbol and/or name change 5135510 APPROVED