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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Postoperative Cognitive Dysfunction
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Accession:DOID:9006358 term browser browse the term
Definition:A short-term decline in cognitive function (especially in memory and thinking) that may last from a few days to a few weeks after major surgery.
Synonyms:exact_synonym: Agitated Emergence;   Agitations, Emergence;   Anesthesia Emergence Delirium;   Emergence Agitation;   Emergence Delirium;   Emergence Excitement;   POCD;   Post-Operative Delirium;   Postanesthetic Excitement;   post-operative delirium;   postoperative confusion;   postoperative delirium
 primary_id: MESH:D000071257
 alt_id: DOID:9000228
 xref: EFO:0009954

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Postoperative Cognitive Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1 angiotensin II receptor type 1 ISO RGD PMID:24814703 RGD:10047100 NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985 		JBrowse link
G Bdnf brain derived neurotrophic factor treatment ISO associated with brain ischemia RGD PMID:29571823 PMID:29599834 PMID:33324197 PMID:34964700 RGD:401959211 RGD:401965400 RGD:401976548 RGD:405850212 NCBI chrNW_004936540:5,530,081...5,582,765
Ensembl chrNW_004936540:5,529,942...5,585,014 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment ISO protein:decreased phosphorylation:hippocampus RGD PMID:29571823 PMID:36688960 PMID:37736695 RGD:401959211 RGD:401959611 RGD:401960090 NCBI chrNW_004936631:3,721,307...3,785,346
Ensembl chrNW_004936631:3,721,313...3,780,892 		JBrowse link
G Gdnf glial cell derived neurotrophic factor treatment ISO protein:decreased expression:hippocampus,urine
protein:altered expression:hippocampus, urine
associated with rheumatic heart disease;protein:increased expression:serum		 RGD PMID:25251457 PMID:28918204 PMID:29512789 PMID:33324197 PMID:34728231 More... RGD:401959611 RGD:405849389 RGD:405850212 RGD:405850250 RGD:405850251 RGD:405866364 NCBI chrNW_004936518:4,291,391...4,310,752
Ensembl chrNW_004936518:4,288,154...4,310,753 		JBrowse link
G Igfbp7 insulin like growth factor binding protein 7 ISO protein:increased expression:plasma (human) RGD PMID:25543030 RGD:401960875 NCBI chrNW_004936482:19,119,339...19,186,679
Ensembl chrNW_004936482:19,118,321...19,186,685 		JBrowse link
G Il1b interleukin 1 beta treatment ISO protein:increased expression:hippocampus (rat) RGD PMID:22959208 PMID:29571823 PMID:33390808 RGD:401959211 RGD:401965467 RGD:7204702 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO human protein in a rat model RGD PMID:23077050 RGD:8551854 NCBI chrNW_004936783:1,447,158...1,466,331
Ensembl chrNW_004936783:1,447,106...1,466,340 		JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:hippocampus (rat) RGD PMID:33390808 RGD:401965467 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Ireb2 iron responsive element binding protein 2 ISO protein:increased expression:hippocampus (rat) RGD PMID:23229539 RGD:12904023 NCBI chrNW_004936471:36,547,552...36,601,327
Ensembl chrNW_004936471:36,547,500...36,600,636 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 treatment ISO protein:decreased phosphorylation:hippocampus RGD PMID:36688960 PMID:37736695 RGD:401959611 RGD:401960090 NCBI chrNW_004936619:1,889,841...1,932,646
Ensembl chrNW_004936619:1,889,708...1,932,646 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 treatment ISO protein:decreased phosphorylation:hippocampus RGD PMID:36688960 PMID:37736695 RGD:401959611 RGD:401960090 NCBI chrNW_004936501:12,342,670...12,390,650
Ensembl chrNW_004936501:12,384,804...12,392,180 		JBrowse link
G Ngf nerve growth factor treatment ISO associated with brain ischemia RGD PMID:29599834 PMID:30481505 PMID:34964700 RGD:401965395 RGD:401965400 RGD:401976548 NCBI chrNW_004936627:635,784...641,290
Ensembl chrNW_004936627:635,788...645,364 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3 group C member 1 treatment ISO associated with Traumatic Brain Injuries;mRNA:decreased expression:hippocampus, hypothalamus RGD PMID:28086911 PMID:36637480 RGD:408345237 RGD:408364984 NCBI chrNW_004936504:10,960,069...11,056,834
Ensembl chrNW_004936504:10,959,192...11,056,856 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3 group C member 2 ISO protein:increased expression:hippocampus (rat) RGD PMID:33390808 RGD:401965467 NCBI chrNW_004936535:1,139,687...1,467,469
Ensembl chrNW_004936535:1,140,178...1,467,471 		JBrowse link
G Tnf tumor necrosis factor treatment ISO protein:increased expression:hippocampus (rat) RGD PMID:29571823 PMID:33390808 RGD:401959211 RGD:401965467 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14614
    Pathological Conditions, Signs and Symptoms 11543
      Pathologic Processes 7246
        Postoperative Complications 726
          Postoperative Cognitive Dysfunction 15
Path 2
Term Annotations click to browse term
  disease 14614
    disease of anatomical entity 14319
      nervous system disease 12593
        central nervous system disease 11247
          brain disease 10564
            disease of mental health 7571
              cognitive disorder 2009
                psychotic disorder 1064
                  substance-induced psychosis 81
                    subacute delirium 17
                      Postoperative Cognitive Dysfunction 15
paths to the root